Airborne radioactive contamination following aerosol ventilation studies

Mackie, Alexandra T.; Hart, G C; Ibbett, D A; Whitehead, Raymond

doi:10.1097/00006231-199403000-00008

Cited by 7 publications

(10 citation statements)

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“…The value of Technegas ventilation imaging for the diagnosis of PE has been described previously 28,29 . This technique has been used for over 16 years and is widely regarded as safe, reliable and extremely easy to use 30–33 . Although aerosolized Tc‐99m diethylene‐triamine pentaacetic acid (DTPA) can produce satisfactory ventilation images in a proportion of patients, Technegas ventilation imaging generally provides more consistent high‐quality ventilation images that allow accurate comparison of ventilation to perfusion for all views 34 .…”

Section: Discussionmentioning

confidence: 99%

“…28,29 This technique has been used for over 16 years and is widely regarded as safe, reliable and extremely easy to use. [30][31][32][33] Although aerosolized Tc-99m diethylene-triamine pentaacetic acid (DTPA) can produce satisfactory ventilation images in a proportion of patients, Technegas ventilation imaging generally provides more consistent high-quality ventilation images that allow accurate comparison of ventilation to perfusion for all views. 34 Kr-81 also has this potential but high cost, and, in some cases limited availability, prohibits its widespread use.…”

Section: Discussionmentioning

confidence: 99%

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Diagnosis of pulmonary embolus using ventilation/perfusion lung scintigraphy: more than 0.5 segment of ventilation/perfusion mismatch is sufficient

Howarth

Booker

Voutnis

2006

Internal Medicine Journal

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Using a simplified diagnostic criterion where all studies showing >0.5 segments of V/Q mismatch are regarded as positive and all others as negative, lung scintigraphy, incorporating Tc-99m Technegas ventilation imaging or its equivalent, can achieve a very high diagnostic accuracy for the detection of PE. Using this technique, less than 5% of scans are indeterminate. A simplified, unambiguous approach to reporting is recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diagnosis of pulmonary embolus using ventilation/perfusion lung scintigraphy: more than 0.5 segment of ventilation/perfusion mismatch is sufficient

Howarth

Booker

Voutnis

2006

Internal Medicine Journal

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“…Indeed, escape of radiopharmaceutical from ventilation scintigraphy delivery systems has been frequently investigated over 3 decades, demonstrating presence of a variable degree of leakage from the aerosol device or patient airways into the examination room ( 26 , 27 , 28 , 29 , 30 ). A similar phenomenon has also been noted with the newest ventilation radiopharmaceutical, 99m Tc-labeled carbon particles (Technegas), where activity was noted to persist in the imaging room air for over one hour following administration ( 31 , 32 ).…”

Section: Challenge To Performing Ventilation During Covid-19 Pandemicmentioning

confidence: 99%

Safe Pulmonary Scintigraphy in the Era of COVID-19

Zuckier

2022

Seminars in Nuclear Medicine

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One of the major effects of the COVID-19 pandemic within nuclear medicine was to halt performance of lung ventilation studies, due to concern regarding spread of contaminated secretions into the ambient air. A number of variant protocols for performing lung scintigraphy emerged in the medical literature which minimized or eliminated ventilation scintigraphy, due to the persistent need to provide this critical diagnostic service without compromising the safety of staff and patients. We have summarized and reviewed these protocols, many of which are based on concepts developed earlier in the history of lung scintigraphy. It is possible that some of these interim remedies may gain traction and earn a more permanent place in the ongoing practice of nuclear medicine.

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“…Lung ventilation imaging is a valuable and widely used diagnostic tool. Air contamination and subsequent doses to staff have been examined for a range of ventilation agents such as 133 Xe, Technegas and DTPA aerosols [1][2][3][4][5]. Under the terms of both the Ionising Radiations Regulations 1999 [6] and Radioactive Substances Act 1993 [7], the level of air contamination should obviously be kept as low as reasonably achievable.…”

Section: Introductionmentioning

confidence: 99%

The use of a modified technique to reduce radioactive air contamination in aerosol lung ventilation imaging

Avison

Hart

2001

J. Radiol. Prot.

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The aim of this study was to reduce airborne contamination resulting from the use of aerosols in lung ventilation scintigraphy. Lung ventilation imaging is frequently performed with 99mTc-diethylenetriaminepentaacetate aerosol (DTPA), derived from a commercial nebuliser. Airborne contamination is a significant problem with this procedure; it results in exposure of staff to radiation and can reduce gamma camera performance when the ventilation is performed in the camera room. We examined the level of airborne contamination resulting from the standard technique with one of the most popular nebuliser kits and tested a modification which significantly reduced airborne contamination. Air contamination was measured while ventilating 122 patients. The modified technique reduced air contamination by a mean value of 64% (p = 0.028) compared with the standard control technique. Additionally, differences in contamination were examined when a mask or mouthpiece was used as well as differences between operators. A simplified method of monitoring air contamination is presented using a commonly available surface contamination monitor. The index so derived was proportional to air contamination (r = 0.88). The problems and regulations associated with airborne contamination are discussed.

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Airborne radioactive contamination following aerosol ventilation studies

Cited by 7 publications

References 0 publications

Diagnosis of pulmonary embolus using ventilation/perfusion lung scintigraphy: more than 0.5 segment of ventilation/perfusion mismatch is sufficient

Diagnosis of pulmonary embolus using ventilation/perfusion lung scintigraphy: more than 0.5 segment of ventilation/perfusion mismatch is sufficient

Safe Pulmonary Scintigraphy in the Era of COVID-19

The use of a modified technique to reduce radioactive air contamination in aerosol lung ventilation imaging

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