Airborne polystyrene microplastics and nanoplastics induce nasal and lung microbial dysbiosis in mice

Zha, Hua; Xia, Jiafeng; Li, Shengjie; Lv, Jitao; Zhuge, Aoxiang; Tang, Ruiqi; Wang, Zhen; Wang, Kaiceng; Chang, Kevin; Li, Lanjuan

doi:10.1016/j.chemosphere.2022.136764

Cited by 28 publications

(20 citation statements)

References 57 publications

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“…7 They also reported that MPs have a stronger effect on lung microbiota than nanoplastics. 7 Zhang et al showed that beneficial bacteria in the nasal and intestinal flora can be reduced by MPs. 32 Chronic sinusitis infection develops a biofilm formation that may play an important role in its pathogenesis and persistence.…”

Section: Discussionmentioning

confidence: 99%

“…6 It has been reported that MPs can affect nasal and lung microbial dysbiosis in mice. 7 Goodman et al have shown that MPs can penetrate the lungs' surface lining layer and are taken up by endothelial cells. 8 Leslie et al have shown that presence of MPs in human blood.…”

Section: Introductionmentioning

confidence: 99%

“…Hirt and Body‐Malapel reported that airborne microplastics accumulate in the nose 6 . It has been reported that MPs can affect nasal and lung microbial dysbiosis in mice 7 . Goodman et al have shown that MPs can penetrate the lungs' surface lining layer and are taken up by endothelial cells 8 .…”

Section: Introductionmentioning

confidence: 99%

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Role of Microplastics in Chronic Rhinosinusitis Without Nasal Polyps

et al. 2023

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ObjectiveWe aimed to examine the relationship between chronic rhinosinusitis without nasal polyps and microplastics.MethodsA total of 80 patients participated in this prospectively planned study. The patients were divided into two groups. Group 1 had 50 patients with chronic rhinosinusitis without nasal polyps, whereas Group 2 had 30 healthy volunteers. The age and gender of the participants were noted. Nose Obstruction Symptom Evaluation questionnaire was applied to the patients. The patients performed nasal lavage with saline. Microplastics were examined in the collected nasal lavage fluids, and their numbers were noted. The groups were compared on these values.ResultsThe mean age was 38.06 ± 14.15 years in the chronic rhinosinusitis group without nasal polyps and 33.60 ± 11.68 years in the control group. There was no significant difference between the groups in terms of age and gender. There was a significant difference in the number of microplastics between the chronic rhinosinusitis group without nasal polyps and the control group (p < 0.001). Microplastics were detected in all participants.ConclusionsWe found more microplastics in patients with chronic rhinosinusitis without nasal polyps. According to this result, we can say that there may be a relationship between chronic rhinosinusitis and microplastics.Level of Evidence3 Laryngoscope, 2023

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of Microplastics in Chronic Rhinosinusitis Without Nasal Polyps

et al. 2023

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“…This dose was estimated based on an approximate equivalence to the human inhalation burden of airborne carbon nanomaterials . The MP/NP dose for inhalation/airway exposure is not yet established. , Exposure doses up to 100 μg MP/NP per mouse have been used in previous rodent exposure models. , …”

Section: Methodsmentioning

confidence: 99%

“…36,37 Exposure doses up to 100 μg MP/NP per mouse have been used in previous rodent exposure models. 38,39 After further feeding in the SPF facility for 48 h, the mice were anesthetized after intraperitoneal injection of 100 μL of sodium pentobarbital at 0.01 g/mL. The exposed serum and the control serum were separated from heart blood by centrifugation.…”

Section: ■ Introductionmentioning

confidence: 99%