Airborne polycyclic aromatic hydrocarbons trigger human skin cells aging through aryl hydrocarbon receptor

Qiao, Yuan; Li, Qiang; Du, Hongyang; Wang, Qiaowei; Huang, Ye; Liu, Wei

doi:10.1016/j.bbrc.2017.04.160

Cited by 39 publications

(36 citation statements)

References 26 publications

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“…Firefighter chemical exposures are linked to an increased risk of melanoma include PAHs, PCBs, and benzene 41 . Furthermore, contact with airborne PAHs can trigger human skin cell aging via cell cycle arrest, cell growth inhibition and apoptosis 42 . Working and leisure pursuits in the Florida outdoors increase risk given moderate to extremely high ambient year‐round ultraviolent levels, a known risk factor for melanoma 7 (https://www.epa.gov/sites/production/files/documents/uviguide.pdf).…”

Section: Discussionmentioning

confidence: 99%

Cancer risk among career male and female Florida firefighters: Evidence from the Florida Firefighter Cancer Registry (1981‐2014)

Lee

Koru‐Sengul

Hernandez

et al. 2020

American J Industrial Med

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Background Firefighters are at increased risk for select cancers. However, many studies are limited by relatively small samples, with virtually no data on the cancer experience of female firefighters. This study examines cancer risk in over 100,000 career Florida firefighters including 5000 + females assessed over a 34‐year period. Methods Florida firefighter employment records (n = 109 009) were linked with Florida Cancer Data System registry data (1981‐2014; ~3.3 million records), identifying 3760 male and 168 female‐linked primary cancers. Gender‐specific age and calendar year‐adjusted odds ratios (aOR) and 95% confidence intervals for firefighters vs non‐firefighters were calculated. Results Male firefighters were at increased risk of melanoma (aOR = 1.56; 1.39‐1.76), prostate (1.36; 1.27‐1.46), testicular (1.66; 1.34‐2.06), thyroid (2.17; 1.78‐2.66) and late‐stage colon cancer (1.19;1.00‐1.41). Female firefighters showed significantly elevated risk of brain (2.54; 1.19‐5.42) and thyroid (2.42; 1.56‐3.74) cancers and an elevated risk of melanoma that approached statistical significance (1.68; 0.97‐2.90). Among male firefighters there was additional evidence of increased cancer risk younger than the age of 50 vs 50 years and older for thyroid (2.55; 1.96‐3.31 vs 1.69; 1.22‐2.34), prostate (1.88; 1.49‐2.36 vs 1.36; 1.26‐1.47), testicular (1.60; 1.28‐2.01 vs 1.47; 0.73‐2.94), and melanoma (1.87; 1.55‐2.26 vs 1.42; 1.22‐1.66) cancers. Conclusion Male career firefighters in Florida are at increased risk for five cancers with typically stronger associations in those diagnosed younger than the age of 50, while there was evidence for increased thyroid and brain cancer, and possibly melanoma risk in female firefighters. Larger cohorts with adequate female representation, along with the collection of well‐characterized exposure histories, are needed to more precisely examine cancer risk in this occupational group.

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Section: Discussionmentioning

confidence: 99%

Cancer risk among career male and female Florida firefighters: Evidence from the Florida Firefighter Cancer Registry (1981‐2014)

Lee

Koru‐Sengul

Hernandez

et al. 2020

American J Industrial Med

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“…Most of these studies focus on the effect of certain AhR modulators on aging or associated parameters. A recent study showed for example that activation of the AhR by airborne polycyclic aromatic hydrocarbons induced cell aging and the expression of aging-related genes in human skin cells (Qiao et al, 2017). Interestingly, the expression of aging-related genes was inhibited by the presence of an AhR antagonist (Qiao et al, 2017).…”

Section: Ahr and Aging In Humansmentioning

confidence: 99%

The Aryl Hydrocarbon Receptor (AhR) in the Aging Process: Another Puzzling Role for This Highly Conserved Transcription Factor

et al. 2020

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Aging is the most important risk factor for the development of major life-threatening diseases such as cardiovascular disorders, cancer, and neurodegenerative disorders. The aging process is characterized by the accumulation of damage to intracellular macromolecules and it is concurrently shaped by genetic, environmental and nutritional factors. These factors influence the functionality of mitochondria, which play a central role in the aging process. Mitochondrial dysfunction is one of the hallmarks of aging and is associated with increased fluxes of ROS leading to damage of mitochondrial components, impaired metabolism of fatty acids, dysregulated glucose metabolism, and damage of adjacent organelles. Interestingly, many of the environmental (e.g., pollutants and other toxicants) and nutritional (e.g., flavonoids, carotenoids) factors influencing aging and mitochondrial function also directly or indirectly affect the activity of a highly conserved transcription factor, the Aryl hydrocarbon Receptor (AhR). Therefore, it is not surprising that many studies have already indicated a role of this versatile transcription factor in the aging process. We also recently found that the AhR promotes aging phenotypes across species. In this manuscript, we systematically review the existing literature on the contradictory studies indicating either pro-or anti-aging effects of the AhR and try to reconcile the seemingly conflicting data considering a possible dependency on the animal model, tissue, as well as level of AhR expression and activation. Moreover, given the crucial role of mitochondria in the aging process, we summarize the growing body of evidence pointing toward the influence of AhR on mitochondria, which can be of potential relevance for aging.

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“…Moreover, there are various causes of skin aging, including ultraviolet radiation, air pollution, smoking, toxic chemicals and so on . The aryl hydrocarbon receptor (AhR)—a sensor of environmental chemicals—is expressed by skin cells, and recent research provides new insights into the role of AhR in skin aging …”

Section: Introductionmentioning

confidence: 99%

“…6 The aryl hydrocarbon receptor (AhR)-a sensor of environmental chemicals-is expressed by skin cells, and recent research provides new insights into the role of AhR in skin aging. 7 In this study, we investigated the changes in the fate of IFE-SCs and the expression of AhR after hydroporation with anti-aging cocktail.…”

mentioning

confidence: 99%

The increase of interfollicular epidermal stem cells and regulation of aryl hydrocarbon receptor and its repressors in the skin through hydroporation with anti‐aging cocktail

Shin

Choi

Yang

et al. 2018

J of Cosmetic Dermatology

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Backgrounds Hydroporation is a procedure that involves a subsonic flow of air and microdroplets into the skin. We previously reported that hydroporation treatment with a cocktail solution containing copper‐glycyl‐L‐histidyl‐L‐lysyl, oligo hyaluronic acid, rhodiola extract, tranexamic acid, and β‐glucan yielded positive effects on skin aging. Objectives The aim of this study was to evaluate the effects of hydroporation with anti‐aging cocktail on interfollicular epidermal stem cells (IFESCs) and expression of aryl hydrocarbon receptor (AhR)/AhR repressor (AhRR) in the skin. Methods Skin samples from six volunteers who were treated with hydroporation were analyzed via confocal microscopic examination. Results Markers for dermal matrix (procollagen type I and fibrillin‐1) and basement membrane (type IV collagen and integrin α6) were increased after treatment. Moreover, there was a significant increase in the expression level of histone deacetylase 1‐positive/p63‐negative basal cells, which we previously reported as interfollicular epidermal stem cells. The expression level of AhR was significantly decreased, whereas that of AhRR was increased. This indicates an alteration in the interaction between the skin and environment posttreatment. Conclusion Anti‐aging hydroporation treatment recovered the stem cell potential of basal cells. Moreover, this treatment decreased AhR and increased AhRR in the skin, which may protect the skin from the harmful environment.

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Airborne polycyclic aromatic hydrocarbons trigger human skin cells aging through aryl hydrocarbon receptor

Cited by 39 publications

References 26 publications

Cancer risk among career male and female Florida firefighters: Evidence from the Florida Firefighter Cancer Registry (1981‐2014)

Cancer risk among career male and female Florida firefighters: Evidence from the Florida Firefighter Cancer Registry (1981‐2014)

The Aryl Hydrocarbon Receptor (AhR) in the Aging Process: Another Puzzling Role for This Highly Conserved Transcription Factor

The increase of interfollicular epidermal stem cells and regulation of aryl hydrocarbon receptor and its repressors in the skin through hydroporation with anti‐aging cocktail

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