2021
DOI: 10.1016/j.scib.2020.08.036
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Airborne fine particulate matter induces cognitive and emotional disorders in offspring mice exposed during pregnancy

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Cited by 28 publications
(31 citation statements)
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“…With the advancements in computer hardware as well as user-friendly software suites, whole-body 3D imaging of a small animal model as the natural extension of the whole-body 2D image may be available. Recently, the whole-body 3D MALDI-MSI has been applied for investigating PM 2.5 toxicity in mouse fetus and demonstrating the disturbed lipid metabolism caused by the gestational exposure to PM 2.5 , 29 which suggested the possibility to obtain a comprehensive understanding of the biochemical processes in the whole-organism level.…”
Section: ■ Introductionmentioning
confidence: 99%
“…With the advancements in computer hardware as well as user-friendly software suites, whole-body 3D imaging of a small animal model as the natural extension of the whole-body 2D image may be available. Recently, the whole-body 3D MALDI-MSI has been applied for investigating PM 2.5 toxicity in mouse fetus and demonstrating the disturbed lipid metabolism caused by the gestational exposure to PM 2.5 , 29 which suggested the possibility to obtain a comprehensive understanding of the biochemical processes in the whole-organism level.…”
Section: ■ Introductionmentioning
confidence: 99%
“…And then, females are placed in a separate cage after successful mating. We collect the whole-body mouse fetus at embryonic day 18 for MALDI-MSI The procedures of MALDI-MSI and histological analysis are described in the previous work of Zhao et al 22,36 . In short, the mouse fetus and human breast tumor samples are sectioned at a 14 μm-thickness by using CryoStar Nx79 cryostat (Thermo Fisher Scientific, Germany).…”
Section: Experimental Datasetsmentioning
confidence: 99%
“…Interestingly, two substructures (SM [d22:0/ 20:4] and Cer [d18:2/24:1]) were identified for the nephrontoxicological assessment of BPS (Figure 4B). We also evaluated the toxicity of airborne fine particulate matter by reconstructing the mouse fetus and acquired the targeted microorgans, such as the dorsal pallium and hippocampal formation regions of fetal brain, placenta, and offspring hippocampus (Zhao, Xie, Yong, et al, 2020). The screening of targeted organ based on 3D-MSI provided a novel approach for pollutant-induced disease studies.…”
Section: Environmental Toxicologymentioning
confidence: 99%
“…To broaden 3D‐MSI applications in environmental toxicology research, our lab has recently carried out a series of studies (Zhao, Xie, Wang, et al, 2018; Zhao, Xie, Yang, et al, 2018; Zhao, Xie, Yong, et al, 2018, 2020; Zhao et al, 2020). Exposure to bisphenol or its alternatives have been associated with the occurrence and development of disease and malignant tumor, including diabetes, cardiovascular diseases and breast cancer (Pupo et al, 2012; Rochester & Bolden, 2015).…”
Section: Applicationsmentioning
confidence: 99%