1994
DOI: 10.1007/bf00754615
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Airborne cytotoxicity in the DiSC assay caused by solutions of treosulfan but not busulphan

Abstract: Treosulfan and busulphan are similar molecules, the former used in the treatment of ovarian cancer and the latter in chronic myelogenous leukaemia. We have used both in the differential staining cytotoxicity (DiSC) assay for in vitro drug sensitivity testing to aid in the choice of chemotherapy for individual patients. It was observed that occasionally the viability of control cells in one assay box was reduced compared with control cells in other boxes from the same assay. Treosulfan was suspected as the caus… Show more

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Cited by 5 publications
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“…1) [27]. In addition, diepoxybutane is volatile and was reported to cause airborne cytotoxicity of treosulfan in vitro.…”
Section: Discussionmentioning
confidence: 99%
“…1) [27]. In addition, diepoxybutane is volatile and was reported to cause airborne cytotoxicity of treosulfan in vitro.…”
Section: Discussionmentioning
confidence: 99%