Small unmanned aerial vehicles are an increasing threat for manned aviation. There is a risk of a mid-air collision between such drones and manned aircraft. Within this paper, drone strikes with various aircraft targets are investigated with numerical simulations. Drone strikes on wing leading edges and helicopter windscreens are simulated. The simulations are performed with the explicit solver Radioss. The FE models of the targets as well as the drone are described in detail. The results show that both drone and target structure suffer severe damage. It depends on the point of impact how severe the damage is. The penetration speed of the windshield is between 85 m/s and 90 m/s. We determine worst-case impact scenarios and discuss, how the target structure may sustain such damage. In this worst-case scenario, a doubling of the windshield is needed to withstand a drone strike. In the case of impacts on wing leading edges, the damage depends strongly on the location. The central impact on a rib shows less damage than the impact between two ribs. From impacts with a speed of 80 m/s onwards, it must be assumed that the airworthiness of the target aircraft is strongly affected.