Airborne antigens from latex gloves

Baur, Xaver; Jäger, D

doi:10.1016/0140-6736(90)90508-3

Cited by 101 publications

(28 citation statements)

References 6 publications

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“…Anaphylactic reactions have been described during gynaecological, surgical and dental procedures [47][48][49][50][51], as well as during barium enema examinations using NRL balloon-tipped catheters [52,53]. The possibility that glove-powder particles act as carriers of NRL allergens was first suggested by LAGIER et al [5] and BAUR and JAEGER [6] based on inhalation challenges. This was further substantiated by TURJANMAA et al [7] who demonstrated that glove powder contains NRL allergens.…”

Section: Exposure To Airborne Nrl Allergensmentioning

confidence: 99%

“…There is now convincing evidence both from in vitro and in vivo experiments that NRL proteins can bind to cornstarch glove powder [7], and function as airborne allergens inducing respiratory reactions through an IgE-mediated mechanism [5,6,9]. Maize allergens in cornstarch powder [22,23], and ethylene oxide used for sterilization [24,25], have been reported as possible causes of immediate allergic reactions to gloves, but these allergens have never been convincingly shown to induce asthma by specific inhalation challenges (SICs).…”

Section: Pathophysiologymentioning

confidence: 99%

“…Asthma may be part of a systemic reaction following contact with NRL, or may result from inhalation of NRL allergens. Although, a number of clinical and research papers on NRL allergy have been published in recent years, relatively few studies [3][4][5][6][7][8][9][10][11][12][13][14][15][16] have specifically addressed the problems raised by asthma due to airborne NRL. However, NRL-induced asthma should receive further medical attention, because it can lead to permanent functional impairment and occupational disability.…”

mentioning

confidence: 99%

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Occupational asthma caused by natural rubber latex

Vandenplas¹

1995

Eur Respir J

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O Oc cc cu up pa at ti io on na al l a as st th hm ma a c ca au us se ed d b by y n na at tu ur ra al l r ru ub bb be er r l la at te ex x Recent studies indicate that asthma is a frequent manifestation of NRL allergy among workers manufacturing NRL materials and among health-care providers using NRL gloves. NRL-induced asthma should receive increasing attention as it can lead to permanent respiratory sequelae and occupational disability. The need for early and accurate diagnosis is outlined and the different diagnostic approaches are reviewed. Specific issues pertaining to the management of affected subjects and to the prevention of exposure to airborne NRL are discussed.Areas of future research should include: 1) further characterization of relevant NRL allergens; 2) development and validation of methods for quantitative assessment of allergen content in NRL devices and workplace environments; 3) standardization of allergen extracts used for diagnostic purposes; 4) prospective evaluation of the natural history and risk factors of NRL-induced asthma; and 5) analysis of effectiveness and cost of preventive strategies.

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Section: Exposure To Airborne Nrl Allergensmentioning

confidence: 99%

Section: Pathophysiologymentioning

confidence: 99%

mentioning

confidence: 99%

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Occupational asthma caused by natural rubber latex

Vandenplas¹

1995

Eur Respir J

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“…Challenge testing by handling boxes gloves can induce immediate sneezing, rhinorrhea, and wheezing in latex-sensitive persons (6,34,60). Turjanmaa et al have demonstrated latex allergens associated with glove powder (78).…”

Section: Respiratory Symptomsmentioning

confidence: 99%

Allergy to latex

Levy

Charpin

Pecquet

et al. 1992

Allergy

129

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The first reported case of an immediate hypersensitivity reaction to latex was described by Nutter in 1979 (52), although this allergy had certainly occurred before that date. During the past 5 years, allergic reactions to products made of natural rubber latex have been reported with increasing frequency, especially in health care personnel and their patients. This phenomenon has been attributed to the recent dramatic rise in the use of latex gloves by medical, dental and auxiliary personnel for protection against the AIDS and hepatitis viruses, although not all authors agree (74), and it might not explain the apparently increased incidence in children with spina bifida and in the general population. It is likely that the increased incidence of allergy to latex among hospital personnel and their patients is related to changes in the manufacturing of gloves and/or to the change from reusable, steam-sterilized to single-use gloves that followed the increased demand for these products. In addition it might be related to better recognition of the clinical problem by the medical community.In this review, we will consider, successively, the epidemiology of allergy to latex including its prevalence and the risk factors for its development, its clinical manifestations, the nature of latex allergens, immunologic mechanisms of latex allergy, diagnostic methods, and the prevention of allergic reactions to products made of natural rubber latex.

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“…Inhalation of latex allergen-coated cornstarch particles from powdered gloves can evoke rhinoconjunctivitis and asthma in latex-allergic healthcare workers [49,50]. Occupational asthma has been described in employees at a rubber-glove manufacturing facility [19].…”

Section: Respiratory Reactionsmentioning

confidence: 99%