Integrating wave energy converters with breakwaters is a promising concept for wave energy utilization. On the basis of fulfilling the wave protection demands, pile-supported Oscillating Water Column (OWC)-type breakwaters can also meet the local needs of electricity far from the lands. In the present study, the wave energy extraction and vortex-induced energy loss of pile-supported OWC-type breakwaters were analyzed based on a two-point measurement method. The importance of energy extraction and vortex-induced energy loss on the wave energy dissipation of pile-supported OWC-type breakwaters were experimentally investigated. It was found that the trends of energy extraction and vortex-induced energy loss were generally correlated. The effects of the pneumatic damping induced by top opening affected the vortex-induced energy loss more than the energy extraction. Results showed that a larger pneumatic damping was preferable for the purpose of increasing energy extraction, whereas for a smaller pneumatic damping the vortex-induced energy loss was more important to the energy dissipation. With increasing draft, the energy extraction decreased, but the vortex-induced energy loss complementally contributed to the total energy dissipation and made the energy dissipation at the same level as that for a shallower draft.