Air pollution, PM 2.5 composition, source factors, and respiratory symptoms in asthmatic and nonasthmatic children in Santiago, Chile

Prieto-Parra, Laura; Yohannessen, Karla; Brea, Cecilia; Vidal, Daniella; Ubilla, Carlos; Ruiz-Rudolph, Pablo

doi:10.1016/j.envint.2017.01.021

Cited by 54 publications

(18 citation statements)

References 58 publications

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“…It is well documented that exposure to environmental pollutants (eg, PM2.5) can induce an oxidative stress and impair lung function in asthmatic patients . ROS are important mediators that may contribute to oxidative damage and chronic inflammation in allergic diseases.…”

Section: Discussionmentioning

confidence: 99%

Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)‐induced epithelial cytokine release through aryl hydrocarbon receptor in asthma

Wang

Liu

et al. 2019

Allergy

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Background Environmental pollutants, which coexist with allergens, have been associated with the exacerbation of asthma. However, the underlying molecular mechanisms remain elusive. We sought to determine whether benzo(a)pyrene (BaP) co‐exposure with dermatophagoides group 1 allergen (Der f 1) can potentiate Der f 1‐induced asthma and its underlying mechanisms. Methods The effect of BaP was investigated in Der f 1‐induced mouse model of asthma, including airway hyper‐responsiveness, allergic inflammation, and epithelial‐derived cytokines. The impact of BaP on Der f 1‐induced airway epithelial cell oxidative stress (ROS) and cytokine release was further analyzed. The role of aryl hydrocarbon receptor (AhR) signaling in BaP‐promoted Der f 1‐induced ROS, cytokine production, and allergic inflammation was also investigated. Results Compared with Der f 1, BaP co‐exposure with Der f 1 led to airway hyper‐responsiveness and increased lung inflammation in mouse model of asthma. Increased expression of TSLP, IL‐33, and IL‐25 was also found in the airways of these mice. Moreover, BaP co‐exposure with Der f 1 activated AhR signaling with increased expression of AhR and CYP1A1 and promoted airway epithelial ROS generation and TSLP and IL‐33, but not IL‐25, expression. Interestingly, AhR antagonist CH223191 or cells with AhR knockdown abrogated the increased expression of ROS, TSLP, and IL‐33. Furthermore, ROS inhibitor N‐acetyl‐L‐cysteine (NAC) also suppressed BaP co‐exposure‐induced expression of epithelial TSLP, IL‐33, and IL‐25. Finally, AhR antagonist CH223191 and NAC inhibited BaP co‐exposure with Der f 1‐induced lung inflammation. Conclusions Our findings suggest that BaP facilitates Der f 1‐induced epithelial cytokine release through the AhR‐ROS axis.

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Section: Discussionmentioning

confidence: 99%

Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)‐induced epithelial cytokine release through aryl hydrocarbon receptor in asthma

Wang

Liu

et al. 2019

Allergy

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“…(), Santiago is “one of the cities with the most serious air pollution problems in the world” because of emissions from vehicles, manufacturing industries, fossil fuel, and wood combustion, coupled with the fact that the city is surrounded by mountain ranges that prevent air drainage. Several epidemiological studies have provided evidence that air pollution exposure has serious health consequences for the population of Santiago (Franck et al ., ; Prieto‐Parra et al ., ).…”

Section: Data Descriptionmentioning

confidence: 97%

Quantifying Personal Exposure to Air Pollution from Smartphone-Based Location Data

Finazzi

Paci

2019

Biometrics

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Personal exposure assessment is a challenging task that requires both measurements of the state of the environment as well as the individual's movements. In this paper, we show how location data collected by smartphone applications can be exploited to quantify the personal exposure of a large group of people to air pollution. A Bayesian approach that blends air quality monitoring data with individual location data is proposed to assess the individual exposure over time, under uncertainty of both the pollutant level and the individual location. A comparison with personal exposure obtained assuming fixed locations for the individuals is also provided. Location data collected by the Earthquake Network research project are employed to quantify the dynamic personal exposure to fine particulate matter of around 2500 people living in Santiago (Chile) over a 4-month period. For around 30% of individuals, the personal exposure based on people movements emerges significantly different over the static exposure. On the basis of this result and thanks to a simulation study, we claim that even when the individual location is known with nonnegligible error, this helps to better assess personal exposure to air pollution. The approach is flexible and can be adopted to quantify the personal exposure based on any location-aware smartphone application. K E Y W O R D SDynamic models, Markov chain Monte Carlo, particulate matter, space-time modeling

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“…A large volume of previous epidemiological studies relied on the use of ground-based fixed national monitoring stations [1,2]. However, recently, inexpensive (<$300) particulate matter (PM) monitors (PM) have been introduced for home usage in South Korea.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Performance of Inexpensive Laser Based PM2.5 Sensor Monitors for Typical Indoor and Outdoor Hotspots of South Korea

2019

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Inexpensive (<$300) real-time particulate matter monitors (IRMs), using laser as a light source, have been introduced for use with a Wi-Fi function enabling networking with a smartphone. However, the information of measurement error of these inexpensive but convenient IRMs are still limited. Using ESCORTAIR (ESCORT, Seoul, Korea) and PurpleAir (PA) (PurpleAir U.S.A.), we evaluated the performance of these two devices compared with the U.S. Environmental Protection Agency (EPA) Federal Equivalent Monitoring (FEM) devices, that is, GRIMM180 (GRIMM Aerosol, Germany) for the indoor measurement of pork panfrying or secondhand tobacco smoking (SHS) and Beta-ray attenuation monitor (BAM) (MetOne, Grants Pass, OR) for outdoor measurement at the national particulate matter (PM2.5) monitoring site near an urban traffic hotspot in Daejeon, South Korea, respectively. The PM2.5 concentrations measured by ESCORTAIR and PA were strongly correlated to FEM (r = 0.97 and 0.97 from indoor pan frying; 0.92 and 0.86 from indoor SHS; 0.85 and 0.88 from outdoor urban traffic hotspot). The two IRMs showed that PM2.5 mass concentrations were increased with increased outdoor relative humidity (RH) levels. However, after applying correction factors for RH, the Median (Interquartile range) of difference compared to FEM was (14.5 (6.1~23.5) %) for PA and 16.3 (8.5–28.0) % for ESCORTAIR, supporting their usage in the home or near urban hotspots.

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Air pollution, PM 2.5 composition, source factors, and respiratory symptoms in asthmatic and nonasthmatic children in Santiago, Chile

Cited by 54 publications

References 58 publications

Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)‐induced epithelial cytokine release through aryl hydrocarbon receptor in asthma

Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)‐induced epithelial cytokine release through aryl hydrocarbon receptor in asthma

Quantifying Personal Exposure to Air Pollution from Smartphone-Based Location Data

Evaluation of Performance of Inexpensive Laser Based PM2.5 Sensor Monitors for Typical Indoor and Outdoor Hotspots of South Korea

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