Air pollution in autoimmune rheumatic diseases: A review

Farhat, Sylvia Costa Lima; Silva, Clóvis A.; Orione, Maria Angélica M.; Campos, Lúcia Maria Arruda; Sallum, Adriana Maluf Elias; Braga, Alfésio Luı́s Ferreira

doi:10.1016/j.autrev.2011.06.008

Cited by 186 publications

(125 citation statements)

References 117 publications

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“…Recently, exposure to tropospheric pollution has been associated with an increased incidence of chronic inflammatory diseases, including autoimmune diseases (18). Bernatsky et al evaluated the association between levels of fine ambient PM and disease activity in adults with SLE.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Air Pollutants and Disease Activity in Juvenile‐Onset Systemic Lupus Erythematosus Patients

Fernandes

Silva

Braga

et al. 2015

Arthritis Care & Research

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Objective. To investigate the association between exposure to air pollutants in the Sao Paulo metropolitan area and disease activity in juvenile-onset systemic lupus erythematosus (SLE) patients. Methods. A longitudinal panel study based on 409 consecutive visits of juvenile-onset SLE patients living in the Sao Paulo metropolitan area was carried out. Disease activity was evaluated in accordance with the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), and the patients were divided into 2 groups: those with SLEDAI scores £8 and those with SLEDAI scores >8. Daily concentrations of inhaled particulate matter (PM 10 ), sulfur dioxide, nitrogen dioxide (NO 2 ), ozone, and carbon monoxide (CO) were evaluated on the 21 days preceding the medical visits. A generalized estimation equation model was used to assess the impact of these measurements on SLEDAI-2K scores, considering the fixed effects for repetitive measurements. The models were adjusted for erythrocyte sedimentation rate, corticosteroid use (daily and cumulative doses), antimalarial use, the use of immunosuppressive agents, the presence of infection 20 days preceding the medical appointment, and the minimum temperature and relative humidity outdoors. Results. PM 10 , NO 2 , and CO were risk factors for juvenile-onset SLE disease activity (SLEDAI-2K score >8) approximately 2 weeks after exposure. A 13.4 mg/m 3 increase in the PM 10 moving average (from lag 12 to lag 15) was associated with a 34% increase (95% confidence interval 7.0-68.0) in the risk of a SLEDAI-2K score >8. Conclusion. This is the first study to show that exposure to inhaled pollutants may increase the risk of disease activity in children with juvenile-onset SLE in a large urban center.

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Section: Discussionmentioning

confidence: 99%

Exposure to Air Pollutants and Disease Activity in Juvenile‐Onset Systemic Lupus Erythematosus Patients

Fernandes

Silva

Braga

et al. 2015

Arthritis Care & Research

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“…, NO 2 , SO 2 , CO e O 3 foram associadas com aumentos de 18,9% (IC95%: 11,5), 19% (IC95%: 8,6), 14,4% (IC95%: 6,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]4), 16,5% (IC95%: 8,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] …”

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Air pollution and children's health: sickle cell disease

et al. 2015

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The hallmarks of sickle cell disease are anemia and vasculopathy. The aim of this study was to assess the association between air pollution and children's emergency room visits of sickle cell patients. We adopted a case-crossover design. Daily counts of children's and adolescents' sickle cell disease emergency room visits from the pediatric emergency unit in São Paulo, Brazil, were evaluated from September 1999 to December 2004, matching by temperature, humidity and controlling for day of the week. Interquartile range increases of the four-day moving averages of PM10, NO2, SO2, CO, and O3 were associated with increases of 18.9% (95%CI: 11.2-26.5), 19% (95%CI: 8.3-29.6), 14.4% (95%CI: 6.5-22.4), 16,5% (95%CI: 8.9-24.0), and 9.8% (95%CI: 1.1-18.6) in total sickle cell emergency room visits, respectively. When the analyses were stratified by pain, PM10 was found to be 40.3% higher than in sickle cell patients without pain symptoms. Exposure to air pollution can affect the cardiovascular health of children and may promote a significant health burden in a sensitive group.

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“…2009; Farhat et al, 2011), central nervous system disorders (Sunderman, 2001;Kreyling et al, 2006;Block and Calderon-Garciduenas, 2009;Pearson et al, 2010;Wang et al, 2012) and diabetes (Andersen, 2012;Andersen et al, 2012). Since many of these health conditions are interlinked, comprehensive studies are required to better understand the impact of PM 2.5 .…”

Section: Introductionmentioning

confidence: 99%

Estimating the global abundance of ground level presence of particulate matter (PM2.5)

et al. 2014

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Abstract. With the increasing awareness of the health impacts of particulate matter, there is a growing need to comprehend the spatial and temporal variations of the global abundance of ground level airborne particulate matter with a diameter of 2.5 microns or less (PM 2.5). Here we use a suite of remote sensing and meteorological data products together with groundbased observations of particulate matter from 8,329 measurement sites in 55 countries taken 1997-2014 to train a machinelearning algorithm to estimate the daily distributions of PM 2.5 from 1997 to the present. In this first paper of a series, we present the methodology and global average results from this period and demonstrate that the new PM 2.5 data product can reliably represent global observations of PM 2.5 for epidemiological studies.

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Air pollution in autoimmune rheumatic diseases: A review

Cited by 186 publications

References 117 publications

Exposure to Air Pollutants and Disease Activity in Juvenile‐Onset Systemic Lupus Erythematosus Patients

Exposure to Air Pollutants and Disease Activity in Juvenile‐Onset Systemic Lupus Erythematosus Patients

Air pollution and children's health: sickle cell disease

Estimating the global abundance of ground level presence of particulate matter (PM2.5)

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