Air pollution, genetic factors and the risk of depression

Fu, Zuqiang; Liu, Qian; Liang, Jingjia; Weng, Zhenkun; Li, Wenxiang; Xu, Jin; Zhang, Xin; Xu, Cheng; Gu, Aihua

doi:10.1016/j.scitotenv.2022.158001

Cited by 31 publications

(19 citation statements)

References 56 publications

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“…Superfund sites contain environmental toxicants that have been linked to changes in brain structure (e.g., gray matter) as well as cognitive and emotional function (Fu et al, 2022; Marshall et al, 2021; Santa Maria et al, 2019; Schwartz et al, 2007). Exposure to these toxicants may be particularly detrimental to children, as their brains continue to develop.…”

Section: Discussionmentioning

confidence: 99%

Hippocampal and amygdala volumes vary with residential proximity to toxicants at Birmingham, Alabama’s 35th Avenue Superfund site.

Buford,

Snidow,

Curiel

et al. 2023

Behavioral Neuroscience

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Exposure to environmental toxicants have serious implications for the general health and well-being of children, particularly during pivotal neurodevelopmental stages. The Environmental Protection Agency's (EPA) Superfund program has identified several areas (Superfund sites) across the United States with high levels of environmental toxicants, which affect the health of many residents in nearby communities. Exposure to these environmental toxicants has been linked to changes in the structure and function of the brain. However, limited research has investigated the relationship between the proximity of childhood homes to a Superfund site and the development of subcortical structures like the hippocampus and amygdala. The present study investigated the hippocampal and amygdala volumes of young adults in relation to the proximity of their childhood homes to Birmingham, Alabama's 35th Avenue Superfund site. Forty participants who either lived within or adjacent to the Superfund site (Proximal group; n = 20) or who lived elsewhere in the greater Birmingham metropolitan area (Distal group; n = 20) were included in this study. Both groups were matched on age, sex, race, and years of education. Magnetic resonance imaging (MRI) was used to compare the gray matter volume of the hippocampus and amygdala between groups. Differences in bilateral hippocampal and left amygdala volumes were observed. Specifically, hippocampal and amygdala volumes were greater in the Proximal than Distal group. These findings suggest that the proximity of children's homes to environmental toxicants may impact the development of the hippocampus and amygdala.

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Section: Discussionmentioning

confidence: 99%

Hippocampal and amygdala volumes vary with residential proximity to toxicants at Birmingham, Alabama’s 35th Avenue Superfund site.

Buford,

Snidow,

Curiel

et al. 2023

Behavioral Neuroscience

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“…Moreover, as potential effect modifiers, hereditary factors may also influence individuals' biological reaction to air pollution exposure and the subsequent development of mental health issues [16]. Currently there were more than one hundred genetic variants known to be associated with depression [51], and participants with a higher genetic risk were more likely to develop depression when exposed to high levels of air pollution [52]. But most studies do not include genetic factors in their models.…”

Section: Discussionmentioning

confidence: 99%

The association between air pollutants and depression in children and adolescents: a systematic review

Lian,

Wan,

et al. 2023

Environ. Res. Commun.

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Depression is a common disease with a high prevalence among children and adolescents. Emerging evidence suggests that air pollution can increase the risk of depression. However, studies examining the relationship between air pollution and depression in children and adolescents are still in their nascent stages. We conducted a systematic review of current studies to investigate how air pollution and air quality issues relating to wildfires affect depression in children and adolescents aged 6 to 19. Our study found that both wildfire-related air exposure and air pollution may be associated with an increased risk of depression among children and teenagers. Ozone exerts a short-term impact on depression in young populations, whereas fine particulate matter (PM2.5) and NO2 have a long-term impact. Heterogeneity exists across studies, necessitating further investigation. Attention should be paid to the effects of air pollution and wildfires on the mental health of children and adolescents.

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“…The role of genetics in increasing susceptibility to depression is recognized [ 6 ]. Cyclic adenosine monophosphate response element binding protein ( CREB1 )—a transcription factor that controls the transcription of numerous neuronal expressed genes—has been shown to be related to both the pathogenesis and treatment of depression [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation between variants of the CREB1 and GRM7 genes and risk of depression

et al. 2023

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The pathogenesis of depression involves cAMP-response element binding protein1 (CREB1) and metabotropic glutamate receptor 7 (GRM7), and their genetic polymorphisms may affect susceptibility to depression. The purpose of this study was to investigate whether the CREB1 polymorphisms rs2253206 and rs10932201 and the GRM7 polymorphism rs162209 are associated with the risk of depression. Using polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing, we analyzed the rs2253206, rs10932201, and rs162209 frequencies in 479 patients with depression and 329 normal controls. The results showed that the rs2253206 and rs10932201 polymorphisms were significantly associated with an increased risk of depression. However, no association was found between rs162209 and depression risk. When the data were stratified for several disease-related variables, none of the three polymorphisms were found to be correlated to onset, disease severity, family history, or suicidal tendency. Thus, the present findings indicate that the CREB1 polymorphisms rs2253206 and rs10932201 may be related to the occurrence of depression.

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Air pollution, genetic factors and the risk of depression

Cited by 31 publications

References 56 publications

Hippocampal and amygdala volumes vary with residential proximity to toxicants at Birmingham, Alabama’s 35th Avenue Superfund site.

Hippocampal and amygdala volumes vary with residential proximity to toxicants at Birmingham, Alabama’s 35th Avenue Superfund site.

The association between air pollutants and depression in children and adolescents: a systematic review

Correlation between variants of the CREB1 and GRM7 genes and risk of depression

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