Air pollution exposure and lung function in highly exposed subjects in Beijing, China: a repeated-measure study

Baccarelli, Andrea; Zheng, Yinan; Zhang, Xiao; Chang, Dou; Liu, Lei; Wolf, Katherine Rose; Zhang, Zhou; McCracken, John P.; Díaz, Anaité; Bertazzi, Pier Alberto; Schwartz, Joel; Wang, Sheng; Kang, Choong-Min; Koutrakis, Petros; Hou, Lifang

doi:10.1186/s12989-014-0051-7

Cited by 83 publications

(46 citation statements)

References 47 publications

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“…Briefly, we used personal samplers worn by study participants during eight hours of work to measure average personal PM 2.5 and its constituents on two separate examination days 1–2 weeks apart. We found high reproducibility of the PM 2.5 measures (r=0.944) in replicate samples from a subset of 24 participants who wore two monitors simultaneously (Baccarelli et al, 2014). BC is a combustion byproduct contained in PM 2.5 that has been used as a surrogate measure for PM 2.5 from gasoline- and diesel-powered motor vehicles (Kinney et al, 2000).…”

Section: Methodsmentioning

confidence: 90%

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Traffic-derived particulate matter exposure and histone H3 modification: A repeated measures study

Zheng

Sanchez-Guerra

Zhang

et al. 2017

Environmental Research

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Background Airborne particulate matter (PM) may induce epigenetic changes that potentially lead to chronic diseases. Histone modifications regulate gene expression by influencing chromatin structure that can change gene expression status. We evaluated whether traffic-derived PM exposure is associated with four types of environmentally inducible global histone H3 modifications. Methods The Beijing Truck Driver Air Pollution Study included 60 truck drivers and 60 office workers examined twice, 1–2 weeks apart, for ambient PM10 (both day-of and 14-day average exposures), personal PM2.5, black carbon (BC), and elemental components (potassium, sulfur, iron, silicon, aluminum, zinc, calcium, and titanium). For both PM10 measures, we obtained hourly ambient PM10 data for the study period from the Beijing Municipal Environmental Bureau’s 27 representatively distributed monitoring stations. We then calculated a 24 h average for each examination day and a moving average of ambient PM10 measured in the 14 days prior to each examination. Examinations measured global levels of H3 lysine 9 acetylation (H3K9ac), H3 lysine 9 tri-methylation (H3K9me3), H3 lysine 27 tri-methylation (H3K27me3), and H3 lysine 36 tri-methylation (H3K36me3) in blood leukocytes collected after work. We used adjusted linear mixed-effect models to examine percent changes in histone modifications per each μg/m3 increase in PM exposure. Results In all participants each μg/m3 increase in 14-day average ambient PM10 exposure was associated with lower H3K27me3 (β=−1.1%, 95% CI: −1.6, −0.6) and H3K36me3 levels (β=−0.8%, 95% CI: −1.4, −0.1). Occupation-stratified analyses showed associations between BC and both H3K9ac and H3K36me3 that were stronger in office workers (β=4.6%, 95% CI: 0.9, 8.4; and β=4.1%, 95% CI: 1.3; 7.0 respectively) than in truck drivers (β=0.1%, 95% CI: −1.3, 1.5; and β=0.9%, 95% CI: −0.9, 2.7, respectively; both pinteraction < 0.05). Sex-stratified analyses showed associations between examination-day PM10 and H3K9ac, and between BC and H3K9me3, were stronger in women (β=10.7%, 95% CI: 5.4, 16.2; and β=7.5%, 95% CI: 1.2, 14.2, respectively) than in men (β=1.4%, 95% CI: −0.9, 3.7; and β=0.9%, 95% CI: −0.9, 2.7, respectively; both pinteraction < 0.05). We observed no associations between personal PM2.5 or elemental components and histone modifications. Conclusions Our results suggest a possible role of global histone H3 modifications in effects of traffic-derived PM exposures, particularly BC exposure. Future studies should assess the roles of these modifications in human diseases and as potential mediators of air pollution-induced disease, in particular BC exposure.

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Section: Methodsmentioning

confidence: 90%

“…Measurements of personal PM 2.5 and black carbon (BC) exposure have been previously described (Baccarelli et al, 2014). Briefly, we used personal samplers worn by study participants during eight hours of work to measure average personal PM 2.5 and its constituents on two separate examination days 1–2 weeks apart.…”

Section: Methodsmentioning

confidence: 99%

Traffic-derived particulate matter exposure and histone H3 modification: A repeated measures study

Zheng

Sanchez-Guerra

Zhang

et al. 2017

Environmental Research

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“…Previous human studies have linked short-term PM 2.5 exposure to a wide range of adverse cardiopulmonary endpoints (1,26,27). However, most of these were observational panel studies, which evaluated changes in health indicators in association with natural day-to-day variations in ambient PM 2.5 concentrations.…”

Section: Discussionmentioning

confidence: 99%

Cardiopulmonary Benefits of Reducing Indoor Particles of Outdoor Origin

Chen

Zhao

Chen

et al. 2015

Journal of the American College of Cardiology

218

111

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Background Indoor exposure to fine particulate matter (PM2.5) from outdoor sources is a major health concern, especially in highly polluted developing countries, such as China. Few studies have evaluated the effectiveness of indoor air purification on the improvement of cardiopulmonary health in these areas. Objectives To evaluate whether a short-term indoor air purifier intervention improves cardiopulmonary health. Methods We conducted a randomized double-blind crossover trial among 35 healthy college students in Shanghai, China in 2014. These students lived in dormitories that were randomized into 2 groups and alternated the use of true or sham air purifiers for 48 h with a 2-week washout interval. We measured 14 circulating biomarkers of inflammation, coagulation and vasoconstriction, lung function, blood pressure (BP), and fractional exhaled nitric oxide (FeNO). We applied linear mixed-effect models to evaluate the effect of the intervention on health outcome variables. Results On average, air purification resulted in a 57% reduction in PM2.5 concentration from 96.2 to 41.3 μg/m3 within hours of operation. Air purification was significantly associated with decreases in geometric means of several circulating inflammatory and thrombogenic biomarkers, including 17.5% in monocyte chemoattractant protein-1, 68.1% in interleukin-1β, 32.8% in myeloperoxidase and 64.9% in soluble CD40 ligand. Further, systolic BP, diastolic BP, and FeNO were significantly decreased by 2.7%, 4.8%, and 17.0% in geometric mean, respectively. The impacts on lung function and vasoconstriction biomarkers were beneficial, but not statistically significant. Conclusion This intervention study demonstrated clear cardiopulmonary benefits of indoor air purification among young, healthy adults in a Chinese city with severe ambient particulate air pollution. (Intervention Study on the Health Impact of Air Filters in Chinese Adults; NCT02239744)

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“…Molecules of primary importance in cement dust in terms of content and potential health effects basically include 60–67% calcium oxide, 17–25 silicon oxide (SiO 2 ), and 3–5% aluminium (Al) oxide, with some amount of iron oxide, chromium (Cr), potassium, sodium, sulphur, and magnesium oxide [1, 2]. Occupational exposures to aluminum (Al), iron (Fe), calcium (Ca), and silicon (Si) have been associated with decreased lung function indicators in exposed workers [3, 4]. Hepatosplenic silicosis and hepatic porphyria, with associated changes in liver function parameters, have also been described as some of the systemic effects of silica.…”

Section: Introductionmentioning

confidence: 99%

Cement Dust Exposure and Perturbations in Some Elements and Lung and Liver Functions of Cement Factory Workers

Richard

Nsonwu-Anyanwu

Jeremaiah

et al. 2016

Journal of Toxicology

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Background. Cement dust inhalation is associated with deleterious health effects. The impact of cement dust exposure on the peak expiratory flow rate (PEFR), liver function, and some serum elements in workers and residents near cement factory were assessed. Methods. Two hundred and ten subjects (50 workers, 60 residents, and 100 controls) aged 18–60 years were studied. PEFR, liver function {aspartate and alanine transaminases (AST and ALT) and total and conjugated bilirubin (TB and CB)}, and serum elements {lead (Pb), copper (Cu), manganese (Mn), iron (Fe), cadmium (Cd), selenium (Se), chromium (Cr), zinc (Zn), and arsenic (As)} were determined using peak flow meter, colorimetry, and atomic absorption spectrometry, respectively. Data were analysed using ANOVA and correlation at p = 0.05. Results. The ALT, TB, CB, Pb, As, Cd, Cr, Se, Mn, and Cu were significantly higher and PEFR, Fe, and Zn lower in workers and residents compared to controls (p < 0.05). Higher levels of ALT, AST, and Fe and lower levels of Pb, Cd, Cr, Se, Mn, and Cu were seen in cement workers compared to residents (p < 0.05). Negative correlation was observed between duration of exposure and PEFR (r = −0.416, p = 0.016) in cement workers. Conclusions. Cement dust inhalation may be associated with alterations in serum elements levels and lung and liver functions while long term exposure lowers peak expiratory flow rate.

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Air pollution exposure and lung function in highly exposed subjects in Beijing, China: a repeated-measure study

Cited by 83 publications

References 47 publications

Traffic-derived particulate matter exposure and histone H3 modification: A repeated measures study

Traffic-derived particulate matter exposure and histone H3 modification: A repeated measures study

Cardiopulmonary Benefits of Reducing Indoor Particles of Outdoor Origin

Cement Dust Exposure and Perturbations in Some Elements and Lung and Liver Functions of Cement Factory Workers

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