Air Pollution and Serum C-reactive Protein Concentration in Children

Shima, Masayuki

doi:10.2188/jea.17.169

Cited by 24 publications

(16 citation statements)

References 40 publications

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“…We used these symptoms to create an infectious illness summary variable, assigning a positive value when the participant had experienced fever/cough/sore throat, diarrhea or other infectious illness, and a noncommunicable illness summary variable, assigning a positive value when the participant had experienced heart disease/chest pain or other noncommunicable illness symptoms. We also separately examined several symptoms previously associated with elevated CRP in children and adults, including fever/cough/sore throat, diarrhea, heart conditions, and asthma (Filteau et al 1995; Kushner et al 2006; McDade et al 2009b; Shima 2007). In addition to these one-month recall measures, participants were asked if they were sick or had experienced a limited set of symptoms in the 24-hours preceding blood collection.…”

Section: Methodsmentioning

confidence: 99%

Pathogenic and obesogenic factors associated with inflammation in Chinese children, adolescents and adults

Thompson

Houck

Adair

et al. 2013

American J Hum Biol

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Objectives Influenced by pathogen exposure and obesity, inflammation provides a critical biological pathway linking changing environments to the development of cardiometabolic disease. This study tests the relative contribution of obesogenic and pathogenic factors to moderate and acute CRP elevations in Chinese children, adolescents and adults. Methods Data come from 8795 participants in the China Health and Nutrition Study. Age-stratified multinomial logistic models were used to test the association between illness history, pathogenic exposures, adiposity, health behaviors and moderate (1-10 mg/L in children and 3-10 mg/L in adults) and acute (>10mg/L) CRP elevations, controlling for age, sex and clustering by household. Backward model selection was used to assess which pathogenic and obesogenic predictors remained independently associated with moderate and acute CRP levels when accounting for simultaneous exposures. Results Overweight was the only significant independent risk factor for moderate inflammation in children (RRR 2.10, 95%CI 1.13-3.89). History of infectious (RRR 1.28, 95%CI 1.08-1.52) and non-communicable (RRR 1.37, 95%CI 1.12-1.69) disease, overweight (RRR 1.66, 95%CI 1.45-1.89) and high waist circumference (RRR 1.63, 95%CI 1.42-1.87) were independently associated with a greater likelihood of moderate inflammation in adults while history of infectious disease (RRR 1.87, 95%CI 1.35-2.56) and overweight (RRR 1.40, 95%CI 1.04-1.88) were independently associated with acute inflammation. Environmental pathogenicity was associated with a reduced likelihood of moderate inflammation, but a greater likelihood of acute inflammation in adults. Conclusions These results highlight the importance of both obesogenic and pathogenic factors in shaping inflammation risk in societies undergoing nutritional and epidemiological transitions.

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Section: Methodsmentioning

confidence: 99%

Pathogenic and obesogenic factors associated with inflammation in Chinese children, adolescents and adults

Thompson

Houck

Adair

et al. 2013

American J Hum Biol

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“…The EPA concluded the number of studies was too limited to come to a conclusion about inflammatory markers in the blood. Only one further study, suggesting increased levels of serum C-reactive protein in children, has been published since (Shima, 2007). Goldberg et al (2008) found positive and statistically significant associations of SO 2 with reduced oxygen saturation and increased pulse rate in congestive heart failure patients.…”

Section: Panel Studiesmentioning

confidence: 99%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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This document presents answers to 24 questions relevant to reviewing European policies on air pollution and to addressing health aspects of these policies. The answers were developed by a large group of scientists engaged in the WHO project "Review of evidence on health aspects of air pollution -REVIHAAP". The experts reviewed and discussed the newly accumulated scientific evidence on the adverse effects on health of air pollution, formulating science-based answers to the 24 questions. Extensive rationales for the answers, including the list of key references, are provided. The review concludes that a considerable amount of new scientific information on the adverse effects on health of particulate matter, ozone and nitrogen dioxide, observed at levels commonly present in Europe, has been published in recent years. This new evidence supports the scientific conclusions of the WHO air quality guidelines, last updated in 2005, and indicates that the effects in some cases occur at air pollution concentrations lower than those serving to establish these guidelines. It also provides scientific arguments for taking decisive actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.This publication arises from the project REVIHAAP and has been co-funded by the European Union. Keywords AIR POLLUTANTS AIR POLLUTION -ADVERSE EFFECTS ENVIRONMENT AND PUBLIC HEALTH EVIDENCE BASED PRACTICE GUIDELINES HEALTH POLICYAddress requests about publications of the WHO Regional Office for Europe to: Publications WHO Regional Office for Europe Scherfigsvej 8 DK-2100 Copenhagen Ø, Denmark Alternatively, complete an online request form for documentation, health information, or for permission to quote or translate, on the Regional Office web site (http://www.euro.who.int/pubrequest). © World Health Organization 2013All rights reserved. The Regional Office for Europe of the World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full.The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate borderlines for which there may not yet be full agreement.The mention of specific companies or of certain manufacturers products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. ...

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“…A study conducted among 2094 Japanese children found that an increased CRP above the 90th percentile (1.4 mg/L) was significantly associated with 3-year mean levels of suspended particulate matter (SPM) [odds ratio (OR) = 1.49, 95% confidence interval (CI) 1.07 – 2.06] (36). A study of 374 children in Iran found that levels of PM 10 on the previous 7 days were significantly associated with CRP concentration (p < 0.0001) (37).…”

Section: Cross-sectional Studiesmentioning

confidence: 99%

Effect of particulate matter air pollution on C-reactive protein: a review of epidemiologic studies

Rittenhouse-Olson²,

Scheider³

et al. 2012

Reviews on Environmental Health

105

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Inflammatory response is implicated as a biologic mechanism that links particulate matter (PM) air pollution with health effects. C-reactive protein (CRP), an important acute-phase reactant with profound proinflammatory properties, is used clinically as an indicator of the presence and intensity of inflammation. In vitro and in vivo animal studies suggest that CRP levels increase in response to PM exposure, but there was no consistency in epidemiologic studies. Herein, a systematic review was conducted to examine the association between PM exposure and serum CRP levels in humans. Elevated CRP levels were consistently found among children, and CRP elevations were also observed among healthy adults, albeit requiring higher peak levels of PM exposure. PM-induced CRP responses were not consistently found in adults with chronic inflammatory conditions, perhaps because of the use of anti-inflammatory medications in this population. Of the eight examined randomized trials, only one trial with a longer intervention period supported the effect of PM exposure on CRP concentrations. To provide conclusive evidence, further epidemiologic studies are needed to better quantify the magnitude of CRP level changes in response to PM with well-defined study populations and better control of various confounding factors.

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Air Pollution and Serum C-reactive Protein Concentration in Children

Cited by 24 publications

References 40 publications

Pathogenic and obesogenic factors associated with inflammation in Chinese children, adolescents and adults

Pathogenic and obesogenic factors associated with inflammation in Chinese children, adolescents and adults

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Effect of particulate matter air pollution on C-reactive protein: a review of epidemiologic studies

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