Air pollution and risk of type 2 diabetes mellitus: A systematic review and meta-analysis

Balti, Eric Vounsia; Echouffo‐Tcheugui, Justin B.; Yako, Yandiswa Y; Kengne, André Pascal

doi:10.1016/j.diabres.2014.08.010

Cited by 152 publications

(121 citation statements)

References 44 publications

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“…The epidemiological evidence linking particulate matter air pollutants and diabetes has been summarized in many recent systematic reviews with meta-analyses [20][21][22][23][24], published mostly in 2014 and 2015. Obviously, many of these reviews made reference to the same studies; however, depending on inclusion and exclusion criteria, not all metaanalyses included the same studies.…”

Section: Particulate Matter Pollutants and Risk Of Diabetes: The Epidmentioning

confidence: 99%

“…Table 1 summarizes the results of the five meta-analyses so far published on the relationship between exposure to particulate matter pollutants and diabetes. Risk of future diabetes was assessed specifically in three meta-analyses [20,21,24], while the other two meta-analyses has mortality as outcome, either alone [23] or combined with risk of diabetes [22].…”

Section: Particulate Matter Pollutants and Risk Of Diabetes: The Epidmentioning

confidence: 99%

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Particulate matter pollutants and risk of type 2 diabetes: a time for concern?

Esposito

Petrizzo²,

Maiorino

et al. 2015

Endocrine

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The World Health Organization estimates that worldwide in 2012 around 7 million deaths occurred prematurely due to air pollution, which is now the world's largest single environmental health risk. The higher premature mortality associated with air pollution is due to exposure to small particulate matter of 10 microns (PM10) or less in diameter. Exposure to air pollution has also been suggested as a contributing to diabetes incidence and progression. There are a number of possible biological pathways linking air pollutants to diabetes, including endothelial dysfunction, dysregulation of the visceral adipose tissue through inflammation, hepatic insulin resistance, elevated hemoglobin A1c level, elevated blood pressure, and alterations in autonomic tone, which may increase insulin resistance. The risk of future diabetes associated with exposure to 10 μg/m(3) increase of PM2.5 has been quantified in the range of 10 to 27%; the risk of diabetes mortality associated with PM2.5 appears to be quite lower, around 1% for each increment exposure of 10 μg/m(3) of both PM2.5 and PM10. Limitations of the current epidemiological evidence include the complex mixture of pollutants, the different design of the studies, the limited data available for non Western populations, and the lack of demonstration that improvement of air quality is associated with a decrease incidence of type 2 diabetes. Although the most sources of outdoor air pollution are well beyond the control of individuals, people should be informed that there are means to reduce the burden of air pollutants on diabetes risk, including avoidance of passive smoking, adoption of an healthy diet, and increasing leisure-time physical activity.

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Section: Particulate Matter Pollutants and Risk Of Diabetes: The Epidmentioning

confidence: 99%

Section: Particulate Matter Pollutants and Risk Of Diabetes: The Epidmentioning

confidence: 99%

Particulate matter pollutants and risk of type 2 diabetes: a time for concern?

Esposito

Petrizzo²,

Maiorino

et al. 2015

Endocrine

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“…This may not be representative of the levels of pollutants which people are exposed too therefore the results should be viewed with caution. Another similar study found inconclusive evidence regarding a link to diabetes [32]. Another health effect found was a reduction in fertility rates associated with particulate matter.…”

Section: Additional Health Effectsmentioning

confidence: 87%

A meta-analysis of the impact of traffic-related air pollution on health and the factors affecting exposure

Lockhart

Vaganay

Macintyre

et al. 2015

WIT Transactions on Ecology and the Environment

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Clean air is a basic requirement for health and well-being. One of the main sources of air pollution is traffic. It emits harmful pollutants including nitrogen dioxide and particulate matter. There is a large body of existing evidence regarding the public health impact of air pollution. A wide range of health problems including respiratory and cardiovascular illnesses have been found. The evidence in relation to the impact of traffic related air pollution is inconsistent therefore the aim of this paper is to provide clarity on the strength of evidence. In addition, the review will consider the impact of environmental and personal exposure factors. To identify relevant research, the database Science Direct was used along with a search strategy. This review found there is a large body of evidence in relation to air pollution from traffic, health impacts and environmental factors. Due to methodological limitations and the complexity of the interactions the strength of this evidence is mixed. Links to cardiovascular illnesses were considered the most significant. A number of environmental factors such as weather and built environment have significant impacts on traffic related air pollution levels. The review highlights the lack of comprehensive and robust evidence linking environmental factors, traffic related air pollution and health impacts. Future work should use appropriate methodologies to address these gaps.

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“…PM with an aerodynamic diameter equal or less than 10 µm size (PM10) can gain easy access to the human body and affect different organ systems [4]. Dermatological (irritations, rashes, pigmentations) [5], ocular (corneal irritation, conjunctivitis) [6], respiratory (cough, allergic rhinitis, chronic obstruction of the airways) [7][8][9], cardiovascular (palpitations, atherosclerosis) [10,11], neurological (cerebrovascular accidents) [12][13][14][15][16], immunological (allergy, inflammation) [17,18], metabolic (diabetes mellitus, dyslipidaemia) diseases [19,20] and cancers [21,22] are associated with PM.…”

Section: Of 12mentioning

confidence: 99%

Evaluation of the Effects of Airborne Particulate Matter on Bone Marrow-Mesenchymal Stem Cells (BM-MSCs): Cellular, Molecular and Systems Biological Approaches

Abu‐Elmagd

Alghamdi

Shamy

et al. 2017

Preprint

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Particulate matter (PM) contains heavy metals that affect various cellular functions and gene expression associated with an array of acute and chronic diseases, in humans. However, their specific effects on the stem cells remain unclear. Here, we report the effects of PM collected from Jeddah city on bone marrow mesenchymal stem cells (BM-MSCs) on proliferation, cell death, related gene expression and systems biological analysis aiming to understand the underlying mechanisms. Two different sizes (PM2.5-10) were tested in vitro at various concentrations (15 to 300 µg/ml) and durations (24 to 72 h). PMs induced cellular stress including membrane damage, shrinkage and death. Lower concentrations of PM2.5 increased BM-MSCs proliferation, while higher concentrations decreased it. PM10 decreased BM-MSCs proliferation in a concentration-dependant manner. The XRay Fluorescence spectrometric analysis showed that PM contains high levels of heavy metals. Ingenuity Pathway Analysis (IPA) and hierarchical clustering analyses showed that heavy metals were associated with signalling pathways involving cell stress/death, cancer and chronic diseases. qRT-PCR results showed differential regulation of the apoptosis genes (BCL2, BAX); upregulation of inflammation associated genes (TNF-α and IL-6) and downregulation of cell cycle regulation gene (P53). We conclude that PM could affect different cellular functions and predispose to debilitating diseases.

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Air pollution and risk of type 2 diabetes mellitus: A systematic review and meta-analysis

Cited by 152 publications

References 44 publications

Particulate matter pollutants and risk of type 2 diabetes: a time for concern?

Particulate matter pollutants and risk of type 2 diabetes: a time for concern?

A meta-analysis of the impact of traffic-related air pollution on health and the factors affecting exposure

Evaluation of the Effects of Airborne Particulate Matter on Bone Marrow-Mesenchymal Stem Cells (BM-MSCs): Cellular, Molecular and Systems Biological Approaches

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