Air pollution and occurrence of type 2 diabetes in a large cohort study

Renzi, Matteo; Cerza, Francesco; Gariazzo, Claudio; Agabiti, Nera; Cascini, Silvia; Domenicantonio, Riccardo Di; Davoli, Marina; Forastiére, Francesco; Cesaroni, Giulia

doi:10.1016/j.envint.2017.12.007

Cited by 121 publications

(73 citation statements)

References 48 publications

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“…In addition, studies on other types of pollutants (non-persistent) have reported sex-dependent effects on metabolism and diabetes incidence in humans and mice. Air pollution (including NO2, particulate matter, and SO2) was associated with an increased risk of diabetes in women but not in men (Brook et al, 2008;Sohn and Oh, 2017), whereas NOX and O3 was associated with diabetes in both men and women, but the association was stronger in women (Renzi et al, 2018). Polycyclic aromatic hydrocarbons (PAHs) were associated with insulin resistance in women but not in men (Choi et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Long-term metabolic consequences of acute dioxin exposure differ between male and female mice

Hoyeck

Blair

Ibrahim

et al. 2019

Preprint

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Exposure to environmental pollutants is consistently associated with increased diabetes risk in humans. In male mice, acute dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD) exposure supresses insulin secretion. This study investigated the long-term effects of a single TCDD injection (20 µg/kg) on glucose metabolism and beta cell function in male and female mice. TCDD-exposed males displayed modest fasting hypoglycemia for ~4 weeks post-injection, reduced fasting insulin levels for up to 6 weeks, increased insulin sensitivity, and decreased beta cell area. TCDD-exposed females also had long-term suppressed basal plasma insulin levels, and abnormal insulin secretion for up to 6 weeks. Unlike males, TCDD did not impact insulin sensitivity or beta cell area in females, but did cause transient glucose intolerance 4 weeks post-exposure. Our results show that a single exposure to dioxin can supress basal insulin levels long-term in both sexes, but effects on metabolism are sex-dependent.

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Section: Discussionmentioning

confidence: 99%

Long-term metabolic consequences of acute dioxin exposure differ between male and female mice

Hoyeck

Blair

Ibrahim

et al. 2019

Preprint

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“…A total of 6 articles [11,[21][22][23][24]27,31] studied PM 10 as a risk factor,five of them had type2 diabetes as the outcome,another one was gestational diabetes.The cumulative follow-up number was 1,662,778, and the number of people with diabetes was 83,584. Heterogeneity analysis showed that there was no statistical difference between the included studies (P=0.68, I 2 =0%), so the data were combined using the fixed effect model, and the meta-analysis of PM 10 and diabetes risk showed that RR=1.00 (95% CI: 0.99-1.02), the difference was not statistically significant (P>0.05), indicating that PM 10 has no correlation with the risk of diabetes, as shown in Fig.3.…”

Section: Pm10 and Risk Of Diabetesmentioning

confidence: 99%

“…Five articles studied NOx as a risk factor [10][11]13,23,27]. The cumulative follw-up number was 2029159,the number of people with diabetes were 91590.…”

Section: Nox and Risk Of Diabetesmentioning

confidence: 99%

Relationship between air pollutants and risk of diabetes:a cohort study based meta-analysis

Mohemaiti

Simayi

Qin

et al. 2020

Preprint

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Background : To investigate the effects of air pollutants on the incidence of diabetes, and to provide reliable evidence for the prevention and control of diabetes. Method : Electronic databases of PubMed, Embase, Web of Science, Wanfang Digital Periodicals (WANFANG), WeiPu, China National Knowledge Infrastructure (CNKI), Springer, and Ovid were searched. RevMan5.3 software was used for meta analysis of the literature included in this study, I 2 was used to measure the heterogeneity of the research contents of the included literature, and fixed effect model or random effect model was used for combined analysis of the overall incidence of diabetes and the incidence of diabetes under different air pollutants. Result : A total of 22 articles with high overall quality were included in this study, including 2703882 subjects and 535190 patients with diabetes.Pooled effect of the studies was determined using relative risk(RR). PM 10 ( RR =1.00; 95% CI :0.99-1.02, P =0.61), PM 2.5 ( RR =1.02 ; 95% C I:1.01-1.04, P =0.01), NO X ( RR =1.00; 95% CI :1.00-1.01, P =0.006), NO 2 ( RR =1.00; 95% CI :1.00-1.01, P =0.01), O 3 ( RR =1.00; 95% CI :0.99-1.01, P =0.99). No correlation was found between PM 10 , NO 2 , O 3 and the risk of type 2 diabetes. The risk of diabetes increased by 1% in people exposed to total air pollutants, increased by 2% in people exposed to PM 2.5 , and increased by 1% in people exposed to NO X . Conclusion : Results of this paper showed that air pollutants are weakly positively correlated with the risk of diabetes. As to the other influencing factors should be further studied.

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“…Dust particles: PM 10 -coarse particles, with a diameter below 10 μm and PM 2.5 -fine particles, with a diameter of 2.5 μm or less, can bond with various chemical compounds, heavy metals, or microorganisms and can be transferred over long distances, causing negative health effects [2][3][4]. Air pollution increases the risk of chronic obstructive pulmonary disease (COPD), lung cancer, cardiovascular diseases, strokes, allergic diseases, asthma, diabetes, and autoimmune diseases [5][6][7][8][9]. e source of emissions of air pollutants and suspended dust are primarily fuel combustion processes in the energy sector as well as industrial emissions associated with road transport and heating homes.…”

Section: Introductionmentioning

confidence: 99%

Gaseous Pollutants and Particulate Matter (PM) in Ambient Air and the Number of New Cases of Type 1 Diabetes in Children and Adolescents in the Pomeranian Voivodeship, Poland

Michalska

Zorena

Wąż

et al. 2020

BioMed Research International

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The increase in type 1 diabetes mellitus (T1DM) incidence in children is worrying and not yet fully explored. It is suggested that probably air pollution exposure could contribute to the development of T1DM. The aim of the study was to investigate the relationship between the concentration of gaseous pollutants including, nitrogen dioxide (NO2), nitric oxides (NOx), sulphur dioxide (SO2), carbon monoxide (CO), and particulate matter (PM) in the air, and the number of new cases of T1DM in children. The number of new cases of T1DM was obtained from the Clinic of Paediatrics, Diabetology, and Endocrinology, Medical University of Gdańsk. The number of children of 0–18 years old in Pomeranian Voivodeship was acquired from the Statistical Yearbook. The concentrations of PM10 absorbance, NO2, NOx, SO2, and CO were measured at 41 measuring posts, between 1 January 2015 and 31 December 2016. It was detected that the average annual concentration of PM10 was higher than the value acceptable to the WHO. Furthermore, the average 24-hour concentration of PM10 was 92 μg/m3 and was higher compared to the acceptable value of 50 μg/m3 (acc. to EU and WHO). Moreover, the number of new cases of T1DM showed a correlation with the annual average concentration of PM10 (β = 2.396, p<0.001), SO2 (β = 2.294, p<0.001), and CO (β = 2.452, p<0.001). High exposure to gaseous pollutants and particulate matter in ambient air may be one of the factors contributing to the risk of developing T1DM in children. Therefore, it is important to take action to decrease air pollutant emissions in Poland. It is crucial to gradually but consistently eliminate the use of solid fuels, such as coal and wood in households, in favour of natural gas and electricity. The development of new technologies to improve air quality, such as “best available techniques” (BAT) or renewable energy sources (water, wind, and solar generation) is of critical importance as well.

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Air pollution and occurrence of type 2 diabetes in a large cohort study

Cited by 121 publications

References 48 publications

Long-term metabolic consequences of acute dioxin exposure differ between male and female mice

Long-term metabolic consequences of acute dioxin exposure differ between male and female mice

Relationship between air pollutants and risk of diabetes:a cohort study based meta-analysis

Gaseous Pollutants and Particulate Matter (PM) in Ambient Air and the Number of New Cases of Type 1 Diabetes in Children and Adolescents in the Pomeranian Voivodeship, Poland

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