Air Pollution and Lung Cancer: A Review by International Association for the Study of Lung Cancer Early Detection and Screening Committee

Berg, Christine D.; Schiller, Joan H.; Boffetta, Paolo; Cai, Jing; Connolly, Casey; Klinke, Anna; Kitts, Andrea Borondy; Lam, David; Myers, Renelle; Suri, Tejas M; Tammemägi, Martin C.; Yang, Dawei; Lam, Stephen

doi:10.1016/j.jtho.2023.05.024

Cited by 26 publications

(9 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The crude mixture was purified by silica gel column chromatography (methanol/ethyl acetate = 1/10, v/v) to afford white solid (2.12 g, 75%). 1 H NMR (400 MHz, CDCl 3 ) δ (ppm): 2.84 (s, 8 H), 3.05 (t, J = 6.6 Hz, 4 H), 4.58 (t, J = 6.6 Hz, 4 H). 13 C NMR (101 MHz, CDCl 3 ) δ (ppm): 25.94, 37.00, 69.10, 151.88, 168.92.…”

Section: The Preparation Of Nhs-ss-nhs Cross-linkermentioning

confidence: 99%

“…Due to ambient air pollution and lung cancer-related genes activation, lung cancer has become the major cause of cancer-related events, and the number of death rate appears to be increasing and reach 3 million worldwide by 2035 [1]. The clinical study implicates that 70% of lung cancer events are always diagnosed in the medium and late stages and chemotherapy has become one of the important means of treatment [2].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tailored design of NHS–SS–NHS cross-linked chitosan nano-hydrogels for enhanced anti-tumor efficacy by GSH-responsive drug release

Ouyang,

Deng,

Tan

et al. 2024

Biomed. Mater.

View full text Add to dashboard Cite

The traditional chemotherapeutic agents' disadvantages such as high toxicity, untargeting and poor water solubility lead to disappointing chemotherapy effects, which restricts its clinical application. In this work, novel size-appropriate and GSH-responsive nano-hydrogels were successfully prepared via the active ester method between chitosan (containing -NH2) and cross-linker (containing NHS). Especially, the cross-linker was elaborately designed to possess a disulfide linkage (SS) as well as two terminal NHS groups, namely NHS-SS-NHS. These functionalities endowed chitosan-based cross-linked scaffolds with capabilities for drug loading and delivery, as well as a GSH-responsive mechanism for drug release. The prepared nano-hydrogels demonstrated excellent performance applicable morphology, excellent drug loading efficiency (~22.5 %), suitable size (~100 nm) and long-term stability. The prepared nano-hydrogels released over 80% doxorubicin (DOX) after incubation in 10 mM GSH while a minimal DOX release less than 25% was tested in normal physiological buffer (PBS, pH = 7.4). The unloaded nano-hydrogels did not show any apparent cytotoxicity to A 549 cells. In contrast, DOX-loaded nano-hydrogels exhibited marked anti-tumor activity against A 549 cells, especially in high GSH environment. Finally, through fluorescent imaging and flow cytometry analysis, FITC-labelled nano-hydrogels show obvious specific binding to the GSH high-expressing A549 cells and nonspecific binding to the GSH low-expressing A549 cells. Therefore, with this cross-linking approach, our present finding suggests that cross-linked chitosan nano-hydrogel (CLCN) drug carrier improves the anti-tumor effect of the A 549 cells and may serve as a potential injectable delivery carrier.

show abstract

Section: The Preparation Of Nhs-ss-nhs Cross-linkermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tailored design of NHS–SS–NHS cross-linked chitosan nano-hydrogels for enhanced anti-tumor efficacy by GSH-responsive drug release

Ouyang,

Deng,

Tan

et al. 2024

Biomed. Mater.

View full text Add to dashboard Cite

show abstract

“…It has been clearly recognized that outdoor air pollution is a major worldwide public health challenge requiring multiple multi-level public health and policy interventions for lung cancer prevention 101 . There are a range of opportunities for engagement of the medical and health community in the area of outdoor air pollution which have been described in a recent review by the International Association for the Study of Lung Cancer Early Detection and Screening Committee 102 . They include increasing awareness by health care community and patients that exposure to air pollution is the second largest risk factor for lung cancer, advocating for enhanced environmental policies to decrease fossil fuel emissions and use clean, sustainable energy instead; restricting air emission targets to the lowest levels as recommended by the WHO, and support further research into the pathophysiological and carcinogenetic effects of PM 2.5 and other pollutants on human health.…”

Section: Public Health Recommendationmentioning

confidence: 99%

Air pollution and lung cancer

Lam,

Turner

2024

BRN

View full text Add to dashboard Cite

Outdoor air pollution and particulate matter (PM) in outdoor air is a major cause of lung cancer. The purpose of this article is to review the current knowledge regarding the effects of outdoor air pollution on lung cancer development and progression. There is clear and substantial evidence of a link between outdoor ambient air pollution and lung cancer. There is an interplay between environmental exposure and host factors, especially in those with genetic risk. PM can promote development and progression of lung cancer through inflammatory and immune mechanisms on pre-existing oncogenic mutations, by altering the lung microbiome and through metabolic perturbations. There is an urgent need to support efforts to improve air quality by reducing fossil fuel use. Health professionals and policy decision makers play an important role in supporting continued advances in research and implementation of measures to reduce the adverse health effects of outdoor air pollution.

show abstract

“…A series of neoadjuvant immune and targeted therapies are also being developed [4][5][6] . Furthermore, signi cant progress has been made in lung cancer early screening, and identi cation of air pollution, environmental carcinogens, and occupational exposure hazards [7][8][9] . However, it appears that this is far from su cient, and there is a need to further elucidate the pathogenesis and exposure factors of lung cancer.…”

Section: Introductionmentioning

confidence: 99%

A Mendelian randomization study confirmed a causal relationship between high basal metabolic rate levels and increased risk of lung cancer

Yu,

Huang,

Zou

et al. 2023

Preprint

View full text Add to dashboard Cite

Purpose We conducted a two-sample Mendelian randomization (MR) study and performed a reverse causation test to assess the potential causal relationship between basal metabolic rate (BMR) and lung cancer, intending to determine whether genetically predicted BMR levels are a causal factor for lung cancer.Methods We collected data on single nucleotide polymorphisms (SNPs) related to basal metabolic rate (BMR) and lung cancer throughout the whole genome. A total of 599 strongly associated SNPs were selected as proxies for BMR to assess the causal relationship between BMR levels and increased risk of lung cancer. Stratified analyses were performed on different histological types of lung cancer to explore the causal relationship between BMR and non-small cell lung cancer/small cell lung cancer risk. The statistical effect was calculated using the Inverse Variance-Weighted(IVW)method, and sensitivity analysis was conducted to assess pleiotropy and heterogeneity.Result The IVW method determined a potential causal relationship between high BMR levels and lung cancer (OR = 1.23, 95%CI = 1.06–1.43, p < 0.01), while dismissing a reverse causal relationship (OR = 1.00, 95%CI = 0.98–1.01, p = 0.63). The causal relationship between high BMR levels and NSCLC was also confirmed (IVW: OR = 1.32, 95%CI = 1.01–1.74, p < 0.05). Further sensitivity analysis validated the stability of these results.Conclusion Our study results provide the first evidence of a causal relationship between high BMR levels and the risk of lung cancer. Additionally, a positive association between high BMR levels and NSCLC risk was observed, while no relation was found with SCLC, possibly due to the lack of data.

show abstract

Air Pollution and Lung Cancer: A Review by International Association for the Study of Lung Cancer Early Detection and Screening Committee

Cited by 26 publications

References 85 publications

Tailored design of NHS–SS–NHS cross-linked chitosan nano-hydrogels for enhanced anti-tumor efficacy by GSH-responsive drug release

Tailored design of NHS–SS–NHS cross-linked chitosan nano-hydrogels for enhanced anti-tumor efficacy by GSH-responsive drug release

Air pollution and lung cancer

A Mendelian randomization study confirmed a causal relationship between high basal metabolic rate levels and increased risk of lung cancer

Contact Info

Product

Resources

About