Air pollution and diastolic function in elderly women – Results from the SALIA study cohort

Ohlwein, Simone; Klümper, Claudia; Vossoughi, Mohammad; Sugiri, Dorothea; Stolz, Sabine; Vierkötter, Andrea; Schikowski, Tamara; Kara, Kaffer; Germing, Alfried; Quaß, Ulrich; Krämer, Ursula; Hoffmann, Barbara

doi:10.1016/j.ijheh.2016.02.006

Cited by 20 publications

(23 citation statements)

References 39 publications

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“…However, similar to our study, Ohlwein et al failed to observe associations between LVMI and specific air pollutants [19]. Van Hee et al categorized the nearest distance to road as <50 m from A1 or A2 roads compared to <150 m in our study.…”

Section: Discussionsupporting

confidence: 85%

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Residential distance to major roadways and cardiac structure in African Americans: cross-sectional results from the Jackson Heart Study

Weaver

Wellenius

et al. 2017

Environ Health

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BackgroundHeart failure (HF) is a significant source of morbidity and mortality among African Americans. Ambient air pollution, including from traffic, is associated with HF, but the mechanisms remain unknown. The objectives of this study were to estimate the cross-sectional associations between residential distance to major roadways with markers of cardiac structure: left ventricular (LV) mass index, LV end-diastolic diameter, LV end-systolic diameter, and LV hypertrophy among African Americans.MethodsWe studied baseline participants of the Jackson Heart Study (recruited 2000–2004), a prospective cohort of cardiovascular disease (CVD) among African Americans living in Jackson, Mississippi, USA. All cardiac measures were assessed from echocardiograms. We assessed the associations between residential distance to roads and cardiac structure indicators using multivariable linear regression or multivariable logistic regression, adjusting for potential confounders.ResultsAmong 4826 participants, residential distance to road was <150 m for 103 participants, 150–299 m for 158, 300–999 for 1156, and ≥1000 m for 3409. Those who lived <150 m from a major road had mean 1.2 mm (95% CI 0.2, 2.1) greater LV diameter at end-systole compared to those who lived ≥1000 m. We did not observe statistically significant associations between distance to roads and LV mass index, LV end-diastolic diameter, or LV hypertrophy. Results did not materially change after additional adjustment for hypertension and diabetes or exclusion of those with CVD at baseline; results strengthened when modeling distance to A1 roads (such as interstate highways) as the exposure of interest.ConclusionsWe found that residential distance to roads may be associated with LV end-systolic diameter, a marker of systolic dysfunction, in this cohort of African Americans, suggesting a potential mechanism by which exposure to traffic pollution increases the risk of HF.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-017-0226-4) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 85%

“…A study in humans enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA) in the USA found that those who resided <50 m from a major roadway had a 1.4 g/m 2 greater LVMI compared to those who resided >150 m from a major roadway [13]. However, the SALIA study in Germany found no association between NO 2 or PM 10 with LVMI [19]. …”

Section: Introductionmentioning

confidence: 99%

Residential distance to major roadways and cardiac structure in African Americans: cross-sectional results from the Jackson Heart Study

Weaver

Wellenius

et al. 2017

Environ Health

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“…A weak positive correlation was also observed between the NO 2 concentration concentrations of air pollutants also lead to vasoconstriction, impairment of capillary function, and an increase in arterial blood pressure. [22][23][24] In addition, studies on human and animal models showed that exposure to air pollution leads to of fine PM suspended in the air also raises the concentration of fibrinogen, which increases the coagulability and reduces blood fibrynolysis. Due to the mechanisms that are dependent on and independent of the endothelium, high A P value of less than 0.05 was considered significant.…”

Section: Data Are Presented In Tablementioning

confidence: 99%

Evaluation of the influence of air pollution on the number of hospital admissions for acute coronary syndrome in elderly patients (BIA – ACS Registry)

Kuźma

Pogorzelski

Struniawski

et al. 2019

Polish Archives of Internal Medicine

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Poland are cardiovascular diseases. A well-known risk factor for the development of these diseases is air quality. 7 The first incident of mass illness reported due to air pollution was the Meuse Valley fog. The city of Liège in Belgium evolved as a center for chemical industries since the beginning of the industrial revolution. In early December 1930, a very thick fog was observed in this area, which led to respiratory insufficiency among the local residents. Within 3 days, several thousand inhabitants were affected by symptoms and tens of them died. However, the influence of air pollution on human health was put in focus for the first time only in the early 1950s after the Great Smog of London. At the time, 4000 people died from circulatory and respiratory insufficiency between the 5th and 9th of December IntroductIon In 1974, Marc Lalonde, Canada's Minister of Health at the time, published a groundbreaking report titled "A new perspective on the health of Canadians," presenting his studies about concepts in the fields of healthcare. His statement that our health depends in 50% on our lifestyle, 20% on the environment we live in, 20% on our genes, and only 10% on a healthcare system, is one of the current paradigms of public health. 1 However, while special attention is still being paid to proper control of medical risk factors and lifestyle changes as prophylactic measures for cardiovascular diseases, environmental factors, such as air quality, are often ignored, although in the light of modern studies, their health impact is indisputable. 2-6 Currently, the greatest threat to the health and life of people and the leading cause of death in

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“…An inadequate energy supply to heart tissue after exposure to PM 2.5 may be through several feasible mechanisms: (1) an increased demand for energy could be induced by an increased heart rate and arrhythmia triggered by PM 2.5 exposure [97]; (2) insufficient blood perfusion to the heart may result from defective vasomotor regulation [98,99] resulting in ineffective diastole from secondary tachyarrhythmia; and (3) acute damage to the mitochondrial respiratory chain will result in reduced production of adenosine triphosphate [83], which serves as a direct source of energy for heart tissue, resulting in an insufficient energy supply to the heart and a diminished threshold for myocardial ischemia [84,100]. The combined effect of increased consumption and an inadequate supply of energy will promote the onset and development of ACS.…”

Section: Potential Physiopathologic Mechanisms Mediating Pm25-indmentioning

confidence: 99%

Potential Harmful Effects of PM2.5 on Occurrence and Progression of Acute Coronary Syndrome: Epidemiology, Mechanisms, and Prevention Measures

Meng

Zhang

Yang

et al. 2016

IJERPH

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The harmful effects of particulate matter with an aerodynamic diameter of <2.5 µm (PM2.5) and its association with acute coronary syndrome (ACS) has gained increased attention in recent years. Significant associations between PM2.5 and ACS have been found in most studies, although sometimes only observed in specific subgroups. PM2.5-induced detrimental effects and ACS arise through multiple mechanisms, including endothelial injury, an enhanced inflammatory response, oxidative stress, autonomic dysfunction, and mitochondria damage as well as genotoxic effects. These effects can lead to a series of physiopathological changes including coronary artery atherosclerosis, hypertension, an imbalance between energy supply and demand to heart tissue, and a systemic hypercoagulable state. Effective strategies to prevent the harmful effects of PM2.5 include reducing pollution sources of PM2.5 and population exposure to PM2.5, and governments and organizations publicizing the harmful effects of PM2.5 and establishing air quality standards for PM2.5. PM2.5 exposure is a significant risk factor for ACS, and effective strategies with which to prevent both susceptible and healthy populations from an increased risk for ACS have important clinical significance in the prevention and treatment of ACS.

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Air pollution and diastolic function in elderly women – Results from the SALIA study cohort

Cited by 20 publications

References 39 publications

Residential distance to major roadways and cardiac structure in African Americans: cross-sectional results from the Jackson Heart Study

Residential distance to major roadways and cardiac structure in African Americans: cross-sectional results from the Jackson Heart Study

Evaluation of the influence of air pollution on the number of hospital admissions for acute coronary syndrome in elderly patients (BIA – ACS Registry)

Potential Harmful Effects of PM2.5 on Occurrence and Progression of Acute Coronary Syndrome: Epidemiology, Mechanisms, and Prevention Measures

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