Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score

Eze, Ikenna C.; Imboden, Medea; Kumar, Ashish; Eckardstein, Arnold von; Stolz, Daiana; Gerbase, Margaret W.; Künzli, Nino; Pons, Marco; Kronenberg, Florian; Schindler, Christian; Probst‐Hensch, Nicole

doi:10.1016/j.envint.2016.04.032

Cited by 37 publications

(29 citation statements)

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“…Although there are at least seven common variants on MTNR1B influencing glucose metabolism through a common pathway [ 21 ], sleep and circadian studies have only focused on rs10830963 variant [ 24 ]. In essence, following the approach of using scores involving multiple variants for improved prediction of genetic risks [ 25 , 26 ], an MTNR1B genetic risk score (MGRS) based on variants that are not in strong linkage disequilibrium (LD), may better capture individuals at high-risk of melatonin profile dysregulation than single variants.…”

Section: Introductionmentioning

confidence: 99%

Exposure to Night-Time Traffic Noise, Melatonin-Regulating Gene Variants and Change in Glycemia in Adults

Eze

Imboden

Foraster

et al. 2017

IJERPH

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Traffic noise has been linked to diabetes, with limited understanding of its mechanisms. We hypothesize that night-time road traffic noise (RTN) may impair glucose homeostasis through circadian rhythm disturbances. We prospectively investigated the relationship between residential night-time RTN and subsequent eight-year change in glycosylated hemoglobin (ΔHbA1c) in 3350 participants of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), adjusting for diabetes risk factors and air pollution levels. Annual average RTN (Lnight) was assigned to participants in 2001 using validated Swiss noise models. HbA1c was measured in 2002 and 2011 using liquid chromatography. We applied mixed linear models to explore RTN–ΔHbA1c association and its modification by a genetic risk score of six common circadian-related MTNR1B variants (MGRS). A 10 dB difference in RTN was associated with a 0.02% (0.003–0.04%) increase in mean ΔHbA1c in 2142 non-movers. RTN–ΔHbA1c association was modified by MGRS among diabetic participants (Pinteraction = 0.001). A similar trend in non-diabetic participants was non-significant. Among the single variants, we observed strongest interactions with rs10830963, an acknowledged diabetes risk variant also implicated in melatonin profile dysregulation. Night-time RTN may impair glycemic control, especially in diabetic individuals, through circadian rhythm disturbances. Experimental sleep studies are needed to test whether noise control may help individuals to attain optimal glycemic levels.

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Section: Introductionmentioning

confidence: 99%

Exposure to Night-Time Traffic Noise, Melatonin-Regulating Gene Variants and Change in Glycemia in Adults

Eze

Imboden

Foraster

et al. 2017

IJERPH

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“…Swiss TPH has a track record in IDs and NCDs research, which forms the basis for the scientific objectives of this project. Swiss TPH is running the only Swiss-wide chronic disease cohort and biobank (Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults), participates at the forefront of exposome research [ 49 , 71 , 74 ], and its coordinators have vast experience in biobanking (Swiss Biobanking Platform). The Université Félix Houphouët-Boigny is the largest public university in Côte d’Ivoire with several laboratories covering ecology, parasitology, and zoology.…”

Section: Discussionmentioning

confidence: 99%

Côte d’Ivoire Dual Burden of Disease (CoDuBu): Study Protocol to Investigate the Co-occurrence of Chronic Infections and Noncommunicable Diseases in Rural Settings of Epidemiological Transition

Eze¹,

Essé²,

Bassa³

et al. 2017

JMIR Res Protoc

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BackgroundIndividual-level concomitance of infectious diseases and noncommunicable diseases (NCDs) is poorly studied, despite the reality of this dual disease burden for many low- and middle-income countries (LMICs).ObjectiveThis study protocol describes the implementation of a cohort and biobank aiming for a better understanding of interrelation of helminth and Plasmodium infections with NCD phenotypes like metabolic syndrome, hypertension, and diabetes.MethodsA baseline cross-sectional population-based survey was conducted over one year, in the Taabo health and demographic surveillance system (HDSS) in south-central Côte d’Ivoire. We randomly identified 1020 consenting participants aged ≥18 years in three communities (Taabo-Cité, Amani-Ménou, and Tokohiri) reflecting varying stages of epidemiological transition. Participants underwent health examinations consisting of NCD phenotyping (anthropometry, blood pressure, renal function, glycemia, and lipids) and infectious disease testing (infections with soil-transmitted helminths, schistosomes, and Plasmodium). Individuals identified to have elevated blood pressure, glucose, lipids, or with infections were referred to the central/national health center for diagnostic confirmation and treatment. Aliquots of urine, stool, and venous blood were stored in a biobank for future exposome/phenome research. In-person interviews on sociodemographic attributes, risk factors for infectious diseases and NCDs, medication, vaccinations, and health care were also conducted. Appropriate statistical techniques will be applied in exploring the concomitance of infectious diseases and NCDs and their determinants. Participants’ consent for follow-up contact was obtained.ResultsKey results from this baseline study, which will be published in peer-reviewed literature, will provide information on the prevalence and co-occurrence of infectious diseases, NCDs, and their risk factors. The Taabo HDSS consists of rural and somewhat more urbanized areas, allowing for comparative studies at different levels of epidemiological transition. An HDSS setting is ideal as a basis for longitudinal studies since their sustainable field work teams hold close contact with the local population.ConclusionsThe collaboration between research institutions, public health organizations, health care providers, and staff from the Taabo HDSS in this study assures that the synthesized evidence will feed into health policy towards integrated infectious disease-NCD management. The preparation of health systems for the dual burden of disease is pressing in low- and middle-income countries. The established biobank will strengthen the local research capacity and offer opportunities for biomarker studies to deepen the understanding of the cross-talk between infectious diseases and NCDs.Trial RegistrationInternational Standard Randomized Controlled Trials Number (ISRCTN): 87099939; http://www.isrctn.com/ISRCTN87099939 (Archived by WebCite at http://www.webcitation.org/6uLEs1EsX)

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“…Luftverschmutzung ist mit einer Insulinresistenz verbunden [3,4], führt zu einer Beeinträchtigung der β-ZellFunktion [5] und zu einer erhöhten Inzidenz von Typ-2-Diabetes [6].…”

Section: » Luftschadstoffe Wurden Als Neue Risikofaktoren Des Diabeteunclassified

Diabetes Update 2017

Scherbaum

2017

Diabetologe

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Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score

Cited by 37 publications

References 69 publications

Exposure to Night-Time Traffic Noise, Melatonin-Regulating Gene Variants and Change in Glycemia in Adults

Exposure to Night-Time Traffic Noise, Melatonin-Regulating Gene Variants and Change in Glycemia in Adults

Côte d’Ivoire Dual Burden of Disease (CoDuBu): Study Protocol to Investigate the Co-occurrence of Chronic Infections and Noncommunicable Diseases in Rural Settings of Epidemiological Transition

Diabetes Update 2017

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