Air pollution and cytokine responsiveness in asthmatic and non-asthmatic children

Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study

“…In the Stockholm area (BAMSE), but not in the other study areas, NO 2 and PM 2·5 levels decreased by about 30% from 1999 to 2009. 37,38 This may have biased associations with more recent exposure, but is no concern for analyses with early life exposures that solely rely on spatial contrasts within cohorts. The fact that we solely relied on residential exposures and did not include exposure at locations other than home and/or time-activity pattern may be another limitation of our study.…”

Whole Blood Cytokine Response to Local Traffic-Related Particulate Matter in Peruvian Children With and Without Asthma

“…The cytokine responses generated in the WBA were contrasted among groups of subjects, with and without asthma, in order to determine if asthma status (e.g., – no asthma, controlled asthma, uncontrolled asthma) was associated with an altered acute phase immune activity. The human whole blood system serves as a suitable reaction medium for this work as it carries an array of immunologic defense mechanisms (e.g., – innate pattern recognition receptors, complement) that recognizes a wide array of biologically relevant stimuli (Fennrich et al, 1999; Kindinger et al, 2005; Hasiwa et al, 2013; Klümper et al, 2015). Moreover, the WBA maintains the physiologic composition of the donor whole blood system (e.g., – leukocyte subpopulations, antibodies, soluble factors), and allows immune cells to respond to stimuli in their evolved cellular and molecular context (Hartung and Wendel, 1995; Schins et al, 1996).…”

“…More recently, Klümper et al (2015), utilized a WBA approach to aid in evaluating if asthma status modified the effects of air pollution exposure on whole blood cytokine response to a standard PM sample. However, the PM used in the Klümper et al (2015) study was a standard (EHC-93) collected from Ottawa, Canada, in 1993, while the air quality measurements and study subjects were located in Wesel, Germany.…”

“…However, the PM used in the Klümper et al (2015) study was a standard (EHC-93) collected from Ottawa, Canada, in 1993, while the air quality measurements and study subjects were located in Wesel, Germany. Thus, the PM was not native to the subject’s local environment.…”

Efeitos da exposição materna à poluição na biometria e hemodinâmica fetais

“…Elevados níveis de poluição foram associados a aumento: no número de doenças respiratórias, de visitas a emergências hospitalares; maior risco: de acidente vascular cerebral, de desenvolvimento de câncer de pulmão, de evento cardiovascular, como infarto agudo do miocárdio, e aumento do número de crises de falcização em crianças com anemia falciforme, entre outros efeitos negativos (3)(4)(5)(6)(7)(8)(9)(10)(11)(12) .…”