Air pollution and antibodies against modified lipoproteins are associated with atherosclerosis and vascular remodeling in hyperlipemic mice

Soares, Sandra Regina; Carvalho-Oliveira, Regiani; Ramos-Sanchez, Eduardo Milton; Catanozi, Sérgio; Silva, Luiz Fernando Ferreira da; Mauad, Thaís; Gidlund, Magnus; Goto, Hiro; Garcia, Maria Lúcia Bueno

doi:10.1016/j.atherosclerosis.2009.04.041

Cited by 69 publications

(54 citation statements)

References 26 publications

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“…Lipid peroxidation due to catalytic activity of metal-ions is responsible for deterioration of food stuffs leading to cause arthritis and cancer (Gordon 1990; Halliwell et al 1995). The pro-oxidant metals will be converted into stable compounds by metal chelators, which are responsible to reduce the damaging effect (Leopoldini et al 2006; Soares et al 2009). In A. hygrometricus , although cooking decreased Fe + chelating activity ( p < 0.001) (Figure 3(b)), it was not decreased too much and hence chelating agents serve as secondary antioxidants leading to reduce the redox capacity of metal ions.…”

Section: Resultsmentioning

confidence: 99%

Bioactive potential of the wild mushroom Astraeus hygrometricus in South-west India

et al. 2016

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The wild mushroom Astraeus hygrometricus is a traditional delicacy during the monsoon season in South-western India. Bioactive principles and antioxidant potential of uncooked and pressure-cooked tender mushroom have been evaluated. Seven bioactive principles of mushroom (tannins, flavonoids, vitamin C, phytic acid, lycopene, β-carotene and trypsin inhibition) were significantly higher, while total phenolics content was significantly lower in uncooked than in cooked samples. Mushroom was devoid of L-DOPA, whereas only uncooked samples showed haemagglutinin activity against A+ blood group. The principal component analysis of uncooked mushroom showed only two bioactive principles clustered with two antioxidant properties, while in cooked mushroom five bioactive principles clustered with three antioxidant properties depicting the nutraceutical potential of cooked mushroom. Future studies should focus on appropriate thermal treatment, which retain maximum bioactive and antioxidant potential to combat health- and lifestyle-related ailments. The A. hygrometricus is ectomycorrhizal, conservation of its host tree species is utmost importance in improvement and expansion of its yield to sustain food security and economic gains of local tribals.

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Section: Resultsmentioning

confidence: 99%

Bioactive potential of the wild mushroom Astraeus hygrometricus in South-west India

et al. 2016

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“…This review also provides a discussion of the supportive toxicological studies. The studies reporting associations with intima media thickness in human beings are supported by animal studies that show that a 6-month exposure of mice to particles results in substantial increases in atherosclerosis, compared with mice breathing filtered air (Floyd et al, 2009;Soares et al, 2009;Sun et al, 2005Sun et al, , 2008. The Brook et al (2010) review contained a consensus that there was strong mechanistic evidence from animal studies of systemic pro-inflammatory responses and vascular dysfunction or vasoconstriction, supported by controlled exposure studies in human beings.…”

mentioning

confidence: 78%

“…Passengers on 90-110 minute car rides on a busy road demonstrated a decrease in high-frequency heart rate variability and an increase in the ratio of low-frequency to high-frequency components compared with pre-ride measurements (Laumbach et al, 2010). Chronic exposure to urban air pollution (in chambers 20 m from a street with heavy traffic in downtown Sao Paulo) exacerbates the susceptibility of low density lipoprotein to oxidation, atherogenesis and vascular remodelling in hyperlipidemic mice (Soares et al, 2009), and in Swiss mice it presents as coronary arteriolar fibrosis and elastosis (Akinaga et al, 2009). …”

Section: Rationalementioning

confidence: 99%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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This document presents answers to 24 questions relevant to reviewing European policies on air pollution and to addressing health aspects of these policies. The answers were developed by a large group of scientists engaged in the WHO project "Review of evidence on health aspects of air pollution -REVIHAAP". The experts reviewed and discussed the newly accumulated scientific evidence on the adverse effects on health of air pollution, formulating science-based answers to the 24 questions. Extensive rationales for the answers, including the list of key references, are provided. The review concludes that a considerable amount of new scientific information on the adverse effects on health of particulate matter, ozone and nitrogen dioxide, observed at levels commonly present in Europe, has been published in recent years. This new evidence supports the scientific conclusions of the WHO air quality guidelines, last updated in 2005, and indicates that the effects in some cases occur at air pollution concentrations lower than those serving to establish these guidelines. It also provides scientific arguments for taking decisive actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.This publication arises from the project REVIHAAP and has been co-funded by the European Union. Keywords AIR POLLUTANTS AIR POLLUTION -ADVERSE EFFECTS ENVIRONMENT AND PUBLIC HEALTH EVIDENCE BASED PRACTICE GUIDELINES HEALTH POLICYAddress requests about publications of the WHO Regional Office for Europe to: Publications WHO Regional Office for Europe Scherfigsvej 8 DK-2100 Copenhagen Ø, Denmark Alternatively, complete an online request form for documentation, health information, or for permission to quote or translate, on the Regional Office web site (http://www.euro.who.int/pubrequest). © World Health Organization 2013All rights reserved. The Regional Office for Europe of the World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full.The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate borderlines for which there may not yet be full agreement.The mention of specific companies or of certain manufacturers products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. ...

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“…Soares et al addressed this issue by exposing LDL-R -/-mice to 1X ambient air (non-fi ltered) vs. fi ltered air at a location 20 m away from the roadside in downtown Sao Paulo, Brazil. Although mice exposed to non-fi ltered air developed atherosclerotic plaques that were comparable in lipid content to those developed by controls, the aortic walls were thicker, suggesting a PM concentration dependent contribution of other components (either cellular or non-cellular) (Soares et al 2009 ). However, in this study, additional lipid endpoints were magnifi ed by the administration of a high cholesterol diet as is discussed below.…”

Section: Dietmentioning

confidence: 97%

“…This is supported by data showing that exposure to CAPs in the PM 2.5 and UFP size ranges led to increased hepatic lipid peroxidation that was accompanied by an upregulation of Nrf2-regulated anti-oxidant genes in the UFP-exposed mouse livers (Araujo et al 2008 ;Gong et al 2007 ), while PM 2.5 exposure led to enhanced formation of 3-nitrotyrosine residues (Sun et al 2005 ;Ying et al 2009 ). Chronic exposure to urban air pollution enhanced the susceptibility of LDL to oxidation in hyperlipemic LDL-R -/-mice fed a high fat diet (Soares et al 2009 ). Inhalation of diesel exhaust also enhanced lipid peroxidation in the liver (Yin et al 2013 ).…”

Section: Role Of Ros and Infl Ammationmentioning

confidence: 98%

Air Pollution, Lipids and Atherosclerosis

Araujo

Rosenfeld

2015

Molecular and Integrative Toxicology

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Air pollution and antibodies against modified lipoproteins are associated with atherosclerosis and vascular remodeling in hyperlipemic mice

Cited by 69 publications

References 26 publications

Bioactive potential of the wild mushroom Astraeus hygrometricus in South-west India

Bioactive potential of the wild mushroom Astraeus hygrometricus in South-west India

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Air Pollution, Lipids and Atherosclerosis

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