Air Leak Syndrome in Two Very Preterm Infants Born to Mothers with Coronavirus Disease 2019: An Association or a Coincidence?

Reddy, Ajay; Engelhardt, Krystin; Jain, Deepak

doi:10.1055/s-0040-1715180

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…However, the mothers of the patients had chronic diseases, the infants were premature, and pneumothorax developed after connection to a ventilator. 34 These cases of pneumothorax associated with the literature suggest that there is a relationship between COVID-19 infection in pregnancy and increased incidence of spontaneous pneumothorax in infants.…”

Section: Discussionmentioning

confidence: 95%

Increased Rate of Spontaneous Pneumothorax in Infants of COVID-19 Positive Mothers

Gürel

Yıldırım

2022

J Pediatr Infect Dis

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Objective The epidemiological and clinical characteristics of neonates born to women infected with coronavirus disease 2019 (COVID-19) during pregnancy were assessed, and the correlation between this infection and spontaneous pneumothorax in neonates born to mothers with COVID-19 was evaluated in the present study. Methods Records of 14 neonates in the neonatal intensive care unit with pneumothorax were collected and analyzed. Pregnant women were routinely screened for COVID-19 before birth. This study only included the neonates of mothers positive for severe acute respiratory syndrome coronavirus 2 immunoglobulin Mand immunoglobulin G and developing spontaneous pneumothorax. Antenatal, natal and postnatal risk factors, data related to demographic, epidemiological and clinical characteristics, treatment strategies, and breastfeeding history were obtained from medical records. Results The gestational age of the 14 neonates was 30 to 38 weeks. One male infant was born by normal spontaneous vaginal delivery, while all other infants were born by C-section. Though the mothers did not have a diagnosis of COVID-19 in their charts, they all reported one or more symptoms when interviewed. No mother had received a COVID-19 vaccination before or during pregnancy. No mother had undergone a hospital visit or doctor examination due to suspicion of COVID and COVID polymerase chain reaction test. COVID antibody titers were present during admission to hospital before birth. Conclusion The infants of pregnant cases with symptomatic or asymptomatic COVID-19 may develop respiratory distress and pneumothorax. Observational data obtained from case series similar to what is presented here may be accepted as a potential first step to producing hypotheses to test with preclinical or clinical models if it can be expanded in larger cohorts.

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Section: Discussionmentioning

confidence: 95%

Increased Rate of Spontaneous Pneumothorax in Infants of COVID-19 Positive Mothers

Gürel

Yıldırım

2022

J Pediatr Infect Dis

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“…85 Few small case series have described the incidence of pneumothoraces in newborns of mothers with COVID-19. 86 87 Inflammatory markers, such as C-reactive protein, were elevated in these cases, but all infants tested negative for SARS-CoV-2.…”

Section: Outcomes Of Infants Born To Mothers With Covid-19mentioning

confidence: 92%

“…85 Few small case series have described the incidence of pneumothoraces in newborns of mothers with COVID-19. 86,87 Inflammatory markers, such as C-reactive protein, were elevated in these cases, but all infants tested negative for SARS-CoV-2. Some post-discharge follow-up studies have published favorable outcomes among neonates born to mothers with SARS-CoV-2.…”

Section: Outcomes Of Infants Born To Mothers With Covid-19mentioning

confidence: 93%

Mother to Newborn Transmission of SARS-CoV-2 Infection: Evolution of Evidence in 1.5 Years of COVID-19 Pandemic

Gupta

Kamity²,

Sharma

et al. 2022

Am J Perinatol

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Coronavirus disease 2019 (COVID-19) pandemic caused significant mortality and morbidity in people of all age groups worldwide. Given the uncertainty regarding the mode of transmission and potential effects of COVID-19 on pregnant mothers and their newborns, guidelines for taking care of maternal–newborn dyads have evolved tremendously since the pandemic began. There has been an enormous influx of published materials regarding the outcomes of mothers and newborns. Still, multiple knowledge gaps regarding comprehensive information about risk to the mothers and newborns exist, which need to be addressed. Current evidence suggests that mothers with symptomatic COVID-19 infection are at increased risk of severe illness during pregnancy, with a higher need for respiratory support and premature deliveries. Neonates born to mothers with COVID-19 are at increased risk of needing intensive care; however, most newborns do well after birth. As new mutant variants arise, we need to be cautious while proactively understanding any new evolving patterns. All leading health authorities strongly recommend COVID-19 vaccination before or during pregnancy to reduce the risk of maternal morbidities and benefit from passing antibodies to newborns prenatally and via breastmilk. Additionally, there are racial, ethnic, and socioeconomic disparities in outcomes and vaccination coverage for pregnant women. This article summarizes the rapidly evolving evidence for the last 1.5 years and aims to help health care professionals care for mothers with COVID-19 and their newborns. Key Points

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“… 4 5 A recent report also described two preterm infants born to SARS-CoV-2–positive mothers presenting with pneumothoraces. 6 We describe two SARS-CoV-2–negative neonates born to COVID-19–positive mothers, who were admitted to our neonatal intensive care unit (NICU) for respiratory distress and subsequently developed pneumothoraces. Patient information was collected after obtaining parental consent for publication.…”

Section: Figmentioning

confidence: 99%

Pneumothorax in Neonates Born to COVID-19–Positive Mothers: Fact or Fortuity?

Kamity¹,

Nayak²,

Dumpa³

2021

AJP Rep

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Neonates born to mothers with coronavirus disease 2019 (COVID-19) have been largely asymptomatic based on initial reports. All neonates born to mothers with COVID-19 have tested negative for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in our institution (published data as of April 12, 2020). As novel presentations of COVID-19, such as multisystem inflammatory syndrome in children are being increasingly reported, we raise the possibility of increased incidence of pneumothorax in neonates born to SARS-CoV-2–positive mothers. Two recently described neonates with COVID-19 infection were noted to have pneumothoraces. We describe two SARS-CoV-2–negative neonates born to COVID-19–positive mothers at 38 and 33 weeks, respectively, admitted to our neonatal intensive care unit for respiratory distress and subsequently developed pneumothoraces. As diverse clinical presentations in various age groups are being described, it becomes difficult to differentiate the increased incidence of complications related to an underlying illness, from COVID-19–related illness. It remains to be seen if neonates with in utero exposure to SARS-CoV-2 have an elevated inflammatory response with pneumonitis and exaggerated lung disease, similar to adult COVID-19 patients, due to in utero exposure.

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Air Leak Syndrome in Two Very Preterm Infants Born to Mothers with Coronavirus Disease 2019: An Association or a Coincidence?

Cited by 5 publications

References 20 publications

Increased Rate of Spontaneous Pneumothorax in Infants of COVID-19 Positive Mothers

Increased Rate of Spontaneous Pneumothorax in Infants of COVID-19 Positive Mothers

Mother to Newborn Transmission of SARS-CoV-2 Infection: Evolution of Evidence in 1.5 Years of COVID-19 Pandemic

Pneumothorax in Neonates Born to COVID-19–Positive Mothers: Fact or Fortuity?

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