Air-Filled Ultrasound Contrast Agents Do Not Damage the Cerebral Microvasculature or Brain Tissue in Rats

Haggag, Kathrine J.; Russell, David; Walday, Per; Skiphamn, Aud; Torvik, Ansgar

doi:10.1097/00004424-199803000-00001

Cited by 18 publications

(11 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In healthy rats, different air-filled microbubbles (Echovist [Bayer HealthCare], Levovist [Bayer HealthCare] and Albunex [Molecular Biosystems, San Diego, CA, USA]) did not cause lesions of brain microvasculature or parenchyma (Haggag 1998). But in these studies US was used only for confirmation of injected contrast agent, using a 10-MHz probe.…”

Section: Discussionmentioning

confidence: 99%

Effect of Combined Ultrasound and Microbubbles Treatment in an Experimental Model of Cerebral Ischemia

Fatar

Stroick

Griebe

et al. 2008

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Effect of Combined Ultrasound and Microbubbles Treatment in an Experimental Model of Cerebral Ischemia

Fatar

Stroick

Griebe

et al. 2008

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

“…Disruption of the blood-brain barrier may occur in rats after intravenous injection of ultrasound contrast media [17,18].…”

Section: Experimental Findingsmentioning

confidence: 99%

Safety of ultrasound contrast agents

et al. 2005

View full text Add to dashboard Cite

The use of ultrasound contrast agents has increased over recent years. The Contrast Media Safety Committee (CMSC) of the European Society of Urogenital Radiology (ESUR) decided to review the safety of ultrasound contrast agents in humans and to draw up guidelines. A comprehensive literature search and review was carried out. The resulting report was discussed by the CMSC of ESUR and at the 11th European Symposium on Urogenital Radiology in Santiago de Compostela, Spain, in 2004. Ultrasound contrast agents approved for clinical use are well tolerated, and serious adverse reactions are rarely observed. Adverse events are usually minor (e.g. headache, nausea, altered taste, sensation of heat) and self-resolving. These symptoms may not be related to the ultrasound contrast materials as they have also been observed in placebo-control groups. Intolerance to some components may occur. Generalized allergy-like reactions occur rarely. Ultrasound contrast agents are generally safe. The ultrasound scanning time and the acoustic output should be kept to the lowest level consistent with obtaining diagnostic information. Adverse reactions should be treated symptomatically.

show abstract

“…SCADs are temporary with most disappearing within one week 44 . An attempt to recreate SCADs in an animal model by injecting air into rabbits did not lead to SCADs, thereby implicating particulate emboli more in the process 46 …”

Section: Resultsmentioning

confidence: 99%

“…44 An attempt to recreate SCADs in an animal model by injecting air into rabbits did not lead to SCADs, thereby implicating particulate emboli more in the process. 46 Neville et al 9 studied 193 patients undergoing coronary artery bypass surgery and compared them with 73 patients undergoing valvular heart surgery looking at microembolic load detected by left common carotid artery ultrasound and neurocognitive outcomes. Although they found a higher number of emboli during valvular heart surgery, this was not associated with an increase in neurocognitive dysfunction.…”

Section: Direct Correlation Of Gaseous Microemboli Detected By Ultrasmentioning

confidence: 99%

The Effect of Carbon Dioxide Insufflation on Cognitive Function During Cardiac Surgery

Chaudhuri

Marasco

2011

Journal of Cardiac Surgery

View full text Add to dashboard Cite

The use of carbon dioxide (CO(2)) insufflation into the pericardial well has become widespread, and in some units routine. The rationale behind this practice is the fact that CO(2) is more soluble than air leading to fewer gaseous microemboli entering the bloodstream and being transferred to the brain or heart. However, the evidence that this reduces postoperative neurocognitive decline is scant. Although CO(2) insufflation is generally a safe procedure there are case reports of significant complications. The aim of this systematic review is to analyze the current evidence for this practice.

show abstract

Air-Filled Ultrasound Contrast Agents Do Not Damage the Cerebral Microvasculature or Brain Tissue in Rats

Abstract: This study indicates that ultrasound contrast media composed of air microspheres do not cause lesions of the brain microvasculature or parenchyma.

Cited by 18 publications

References 26 publications

Effect of Combined Ultrasound and Microbubbles Treatment in an Experimental Model of Cerebral Ischemia

Effect of Combined Ultrasound and Microbubbles Treatment in an Experimental Model of Cerebral Ischemia

Safety of ultrasound contrast agents

The Effect of Carbon Dioxide Insufflation on Cognitive Function During Cardiac Surgery

Contact Info

Product

Resources

About