A I M , Curley FJ. Gas embolism: Part I. \'enous gas emlmli. J Intensive Care Xlcd 19661 1:181-204. ~ ~Gas emboli syndromes occur in many different settings, and their medical signifimnce ranges from being life-threatening emergencies to being totally innocuous. W'e discuss vcnous gas embolization in hrt I of this review, and it a n rcsult from a variety of traumatic, diagnostic, therapeutic, and surgical interventions. The pathophysiological consequences depend on where the gas bubbles impact and obstruct the circulation-by cmting an 'air lock" in the right ventricle, by obstruction of pulnionary arterioles, and sometimes \vitli passage into the arterial circulation (so called pandoxical emboli). Various monitoring tcchniques arc available and arc known to be usefiil in high-risk patients. Nevcrthclcss, the diagnosis can be difficult to establish. Myriad and generally nonspecific clinical manifestations may he present; the patient may often cxhil>it signs and symptoms suggestive of other acute cardiopulmonar). or central nervous system events. 'Ilie classically descritxd 'mill-wheel murmur" is actually a mrc finding, and it is transient PI best. Iliere arc no specific diagnostic tests anilablc, and clinicians, niust tlcpend on a high level of suspicion in the appropriate settings. Rapid identification of the problem, with prevention of funher gas entry into the venous circulation, slioultl be a routine measure. llic left Iatcnl decutlitus position, administration of 100% o-xygen, and hyperbaric oq'genation should 111 be considered, and they have been shown to bc effective treatment modalities. From thr Division o f I'ulmonary, Allergy and Critical Care blcdicine, Univcrsity of Xlnssnchusctrs Medial Schml. \\brcester AL\. Address corrcspondcnce to Dr \\&on, The Division o f Pulmonary, Allerg7 and Criticd Care Xlcdicine, Univcrsity of X~ass3chu-sctts bletlical School, 55 h k e Ave Konh. \\'orcesrer, XL\ 01655. Kcceived Oct 14,133 1. :ind in r e v i d forni L)cc4,1335. Acceptcd for publimtion Dec 12, 1395.Current beliefs hold that althougli gas embolization arises frequently and from innumerable causes, clinically significant gas ernbolization is a rare clinical entity. It is clear that venous air embolism may occur in numerous clinical, vocational, and recreational settings. However, it is not clear that signifia n t emtioli are rare. \Vhether venous, arterial, or extravascular in location, gaseous enilmli may precipitate full-blown medical emergencies. We discuss these entities separately based on the predominant location of the gas collections, although they are not always separate and distinct. Part I focuses on venous gas embolism (VGE). Part I1 \vilI be concerned with arterial gas embolism anti decompression sickness. On any given day and with almost any given hospitalized patient, we have all witnessed air bubbles being infused into :I patient's venous circulation. W e can easily imagine how this scenario, being repeated so frequently, might lead to serious consideration of VGE as being the most common iatro...