Air Bubbles in Insulin Pumps: A Clinically Relevant Issue?

Heinemann, Lutz

doi:10.1177/19322968221101885

Cited by 6 publications

(4 citation statements)

References 20 publications

(17 reference statements)

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“…When insulin is exposed to a higher temperature, the risk of air bubble formation increases, potentially impacting pump function, especially when the insulin is used directly after refrigeration. [ 11 , 49 ]…”

Section: Discussionmentioning

confidence: 99%

Global Warming and Endocrinology: The Hyderabad Declaration of the South Asian Federation of Endocrine Societies

Bhattacharya,

Sahay,

Afsana

et al. 2024

Indian Journal of Endocrinology and Metabolism

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Global warming and endocrine disorders are intertwined issues posing significant challenges. Greenhouse gases emanating from human activities drive global warming, leading to temperature rise and altered weather patterns. South Asia has experienced a noticeable temperature surge over the past century. The sizable population residing in the region heightens the susceptibility to the impact of global warming. In addition to affecting agriculture, water resources, and livelihood, environmental changes interfere with endocrine functioning. Resulting lifestyle changes increase the risk of metabolic and endocrine disorders. Individuals with diabetes face heightened vulnerability to extreme weather due to impaired thermoregulation. A high ambient temperature predisposes to heat-related illnesses, infertility, and nephropathy. Additionally, essential endocrine drugs and medical devices are susceptible to temperature fluctuations. The South Asian Federation of Endocrine Societies (SAFES) calls for collaboration among stakeholders to combat climate change and promote healthy living. Comprehensive approaches, including the establishment of sustainable food systems, promotion of physical activity, and raising awareness about environmental impacts, are imperative. SAFES recommends strategies such as prioritizing plant-based diets, reducing meat consumption, optimizing medical device usage, and enhancing accessibility to endocrine care. Raising awareness and educating caregivers and people living with diabetes on necessary precautions during extreme weather conditions are paramount. The heat sensitivity of insulin, blood glucose monitoring devices, and insulin pumps necessitates proper storage and consideration of environmental conditions for optimal efficacy. The inter-connectedness of global warming and endocrine disorders underscores the necessity of international collaboration guided by national endocrine societies. SAFES urges all stakeholders to actively implement sustainable practices to improve endocrine health in the face of climate change.

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Section: Discussionmentioning

confidence: 99%

Global Warming and Endocrinology: The Hyderabad Declaration of the South Asian Federation of Endocrine Societies

Bhattacharya,

Sahay,

Afsana

et al. 2024

Indian Journal of Endocrinology and Metabolism

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“…The filling, in particular, if this operation is made by the patient, is a second source of air entrance. Degassing from insulin and air permeation through the reservoir membrane also lead to additional air generation in the insulin reservoir [93].…”

Section: Air In the Insulin Reservoir And Air Filtermentioning

confidence: 99%

Displacement Micropump with Check Valves for Diabetes Care—The Challenge of Pumping Insulin at Negative Pressure

Chappel

2024

Encyclopedia

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The displacement micropump with passive check valves is an attractive solution for precise insulin infusion in patients with type I diabetes. Unlike most insulin pumps that push insulin from a cartridge using a piston, a displacement micropump will first pull insulin from the reservoir before infusing it into the patient. This dual sequence introduces new challenges in terms of insulin stability, notably if the reservoir is not pressurized. After an introduction to displacement micropumps and a brief review of the insulin degradation mechanism, micropump design rules are discussed in light of microfluidic theory.

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“…Also, air bubbles can indirectly cause harm to the patient when they alter the accuracy of therapeutic delivery. Bubbles in an insulin pump can either cause hypoglycemia (low blood sugar) due to its expansion in the insulin reservoir (e.g., during airplane depressurization) or hyperglycemia (high blood sugar) if the air bubble in the catheter lowers the amount of insulin delivered [14].…”

Section: Air-in-line Detectionmentioning

confidence: 99%

Robust alarm design strategy for medical devices: Application to air-in-line detection and occlusion management

Eric Chappel

2023

Global J. Eng. Technol. Adv.

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Alarm fatigue in the hospital environment is a recurring problem that can be solved through technical, human, or organizational considerations. The use of technical factors to get a robust alarm management system is illustrated here by two case studies related to air-in-line detection in peritoneal dialysis and insulin pump occlusion management. Air-in-line sensors are usually very sensitive to the presence of small bubbles stuck on tubing and may therefore deliver false alarms. To provide a reliable estimate of the cumulated air volume pumped an IR sensor technology that is insensitive to small bubbles was implemented and tested. Another strategy was used to limit false occlusion alarms in an insulin patch pump. The piezoelectric actuator of this micropump was servo-controlled to the pressure sensor signal to allow insulin to flow into the patient despite the presence of a partial occlusion. The false alarm rate is thus reduced by using a self-adaptive occlusion detection threshold that has been evaluated using numerical simulations.

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Air Bubbles in Insulin Pumps: A Clinically Relevant Issue?

Cited by 6 publications

References 20 publications

Global Warming and Endocrinology: The Hyderabad Declaration of the South Asian Federation of Endocrine Societies

Global Warming and Endocrinology: The Hyderabad Declaration of the South Asian Federation of Endocrine Societies

Displacement Micropump with Check Valves for Diabetes Care—The Challenge of Pumping Insulin at Negative Pressure

Robust alarm design strategy for medical devices: Application to air-in-line detection and occlusion management

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