Aiming to IgE: Drug development in allergic diseases

Ling, Xiaojing; Wei, Ji‐Fu; Zhu, Ying

doi:10.1016/j.intimp.2023.110495

Cited by 4 publications

(1 citation statement)

References 137 publications

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“…Allergy, one of the most common chronic conditions globally, is an important public health concern due to significant quality-of-life and economic impact 1 – 3 . In recent years, the study of allergic diseases has gained significant attention due to the increasing prevalence of allergies worldwide 4 – 7 . Immunoglobulin E (IgE)-mediated allergy plays a role in the inflammatory processes of various allergic respiratory diseases, affecting approximately one-third of the world's population 8 .…”

Section: Introductionmentioning

confidence: 99%

Impact of ultra-low temperature storage on serum sIgE detection and allergic disease biobank feasibility

Chang,

Hu,

Pan

et al. 2023

Sci Rep

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Research has shown that the concentration and composition of biological samples may change after long-term ultra-low temperature storage. Consequently, this study examined the effect of ultra-low temperature storage on serum sIgE detection by comparing sIgE concentrations at various durations from the time of sample storage to subsequent testing. We selected 40 serum samples from the Guangzhou Medical University Affiliated First Hospital Biobank, which had been tested for house dust mites, dog hair, tobacco mold, cockroaches, and cow milk allergen sIgE. Samples were categorized by storage duration: 14 samples stored for 10 years, 12 for 5 years, and 14 for 3 years. They were also classified by sIgE positive levels: 15 samples at levels 1–2, 15 at levels 3–4, and 10 at levels 5–6. The allergen sIgE of these samples was retested using the same technology. Regardless of the type of allergen or the level of positivity, the majority of sIgE concentrations measured at the time of storage were higher than the current measurements, but the difference was not statistically significant. The correlation between the sIgE results at the time of storage and the current results was high for samples stored for 10 years (rs = 0.991, P < 0.001) and 5 years (rs = 0.964, P < 0.001). Serum allergen sIgE is stable when stored under ultra-low temperature conditions, making the construction of a biological sample bank for allergic diseases feasible. This will facilitate researchers in quickly obtaining samples, conducting technical research, and translating findings, thereby promoting the development of the field of allergy through integration of industry, academia, and research.

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Section: Introductionmentioning

confidence: 99%

Impact of ultra-low temperature storage on serum sIgE detection and allergic disease biobank feasibility

Chang,

Hu,

Pan

et al. 2023

Sci Rep

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The potential of Bruton’s tyrosine kinase (BTK) inhibitors in the pharmacotherapeutic management of immune and dermatological disease

Tseng,

Murrell

2024

Expert Opinion on Pharmacotherapy

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Mast cell stabilizers: from pathogenic roles to targeting therapies

Cao,

Gao

2024

Front. Immunol.

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Mast cells (MCs) are bone-marrow-derived haematopoietic cells that are widely distributed in human tissues. When activated, they will release tryptase, histamine and other mediators that play major roles in a diverse array of diseases/disorders, including allergies, inflammation, cardiovascular diseases, autoimmune diseases, cancers and even death. The multiple pathological effects of MCs have made their stabilizers a research hotspot for the treatment of related diseases. To date, the clinically available MC stabilizers are limited. Considering the rapidly increasing incidence rate and widespread prevalence of MC-related diseases, a comprehensive reference is needed for the clinicians or researchers to identify and choose efficacious MC stabilizers. This review analyzes the mechanism of MC activation, and summarizes the progress made so far in the development of MC stabilizers. MC stabilizers are classified by the action mechanism here, including acting on cell surface receptors, disturbing signal transduction pathways and interfering exocytosis systems. Particular emphasis is placed on the clinical applications and the future development direction of MC stabilizers.

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Aiming to IgE: Drug development in allergic diseases

Cited by 4 publications

References 137 publications

Impact of ultra-low temperature storage on serum sIgE detection and allergic disease biobank feasibility

Impact of ultra-low temperature storage on serum sIgE detection and allergic disease biobank feasibility

The potential of Bruton’s tyrosine kinase (BTK) inhibitors in the pharmacotherapeutic management of immune and dermatological disease

Mast cell stabilizers: from pathogenic roles to targeting therapies

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