AIMing 2 treat atherosclerosis

Soehnlein, Oliver; Tall, Alan R.

doi:10.1038/s41569-022-00755-0

Cited by 12 publications

(5 citation statements)

References 10 publications

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“…47 DNA fragments recognized by AIM2 can be derived from mitochondria, chromosomal DNA and potentially from extracellular sources such as circulating DNA fragments or neutrophil extracellular traps (NETs). 48,49…”

Section: Nlrp3 and Aim2 Inflammasomesmentioning

confidence: 99%

Inflammasomes and Atherosclerosis: a Mixed Picture

Tall

Bornfeldt

2023

Circulation Research

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The CANTOS (Canakinumab Anti-inflammatory Thrombosis Outcome Study) and colchicine trials suggest an important role of inflammasomes and their major product IL-1β (interleukin 1β) in human atherosclerotic cardiovascular disease. Moreover, studies in mouse models indicate a causal role of inflammasomes and IL-1β in atherosclerosis. However, recent studies have led to a more granular view of the role of inflammasomes in atherosclerosis. Studies in hyperlipidemic mouse models suggest that prominent activation of the NLRP3 inflammasome requires a second hit such as defective cholesterol efflux, defective DNA repair, clonal hematopoiesis or diabetes. Similarly in humans some mutations promoting clonal hematopoiesis increase coronary artery disease risk in part by promoting inflammasome activation. Recent studies in mice and humans point to a wider role of the AIM2 (absent in melanoma 2) inflammasome in promoting cardiovascular disease including in some forms of clonal hematopoiesis and diabetes. These developments suggest a precision medicine approach in which treatments targeting inflammasomes or IL-1β might be best employed in clinical settings involving increased inflammasome activation.

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Section: Nlrp3 and Aim2 Inflammasomesmentioning

confidence: 99%

Inflammasomes and Atherosclerosis: a Mixed Picture

Tall

Bornfeldt

2023

Circulation Research

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“… 34 , 35 , 36 AIM2 might be an important target for precision medicine of atherosclerosis. 37 Therefore, this study provides a potential pharmacological intervention targeting the AIM2 inflammasome in atherosclerotic cardiovascular disease.…”

Section: Discussionmentioning

confidence: 96%

TUDCA alleviates atherosclerosis by inhibiting AIM2 inflammasome and enhancing cholesterol efflux capacity in macrophage

Wang,

Zhang,

et al. 2024

iScience

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“…As a novel member of the interferon-induced PYHIN proteins, AIM2 plays a significant role in regulating innate immunity [ 23 ]. Recently, numerous studies, including ours, have shown that AIM2 is associated with pathogenic infections [ 24 , 25 , 26 ]. However, the role of AIM2 in pathogenic C .…”

Section: Discussionmentioning

confidence: 99%

Absent in Melanoma 2 Mediates Inflammasome Signaling Activation against Clostridium perfringens Infection

Ma,

Lou,

Wang

et al. 2024

IJMS

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Absent in melanoma 2 (AIM2), a key component of the IFI20X/IFI16 (PYHIN) protein family, is characterized as a DNA sensor to detect cytosolic bacteria and DNA viruses. However, little is known about its immunological role during pathogenic Clostridium perfringens (C. perfringens) infection, an extracellular bacterial pathogen. In a pathogenic C. perfringens gas gangrene model, Aim2−/− mice are more susceptible to pathogenic C. perfringens soft tissue infection, revealing the importance of AIM2 in host protection. Notably, Aim2 deficiency leads to a defect in bacterial killing and clearance. Our in vivo and in vitro findings further establish that inflammasome signaling is impaired in the absence of Aim2 in response to pathogenic C. perfringens. Mechanistically, inflammasome signaling downstream of active AIM2 promotes pathogen control. Importantly, pathogenic C. perfringens-derived genomic DNA triggers inflammasome signaling activation in an AIM2-dependent manner. Thus, these observations uncover a central role for AIM2 in host defense and triggering innate immunity to combat pathogenic C. perfringens infections.

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AIMing 2 treat atherosclerosis

Cited by 12 publications

References 10 publications

Inflammasomes and Atherosclerosis: a Mixed Picture

Inflammasomes and Atherosclerosis: a Mixed Picture

TUDCA alleviates atherosclerosis by inhibiting AIM2 inflammasome and enhancing cholesterol efflux capacity in macrophage

Absent in Melanoma 2 Mediates Inflammasome Signaling Activation against Clostridium perfringens Infection

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