Aim24 stabilizes respiratory chain supercomplexes and is required for efficient respiration

Deckers, Markus; Balleininger, Martina; Vukotic, Milena; Römpler, Katharina; Bareth, Bettina; Juris, Lisa; Dudek, Jan

doi:10.1016/j.febslet.2014.06.006

Cited by 17 publications

(18 citation statements)

References 49 publications

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“…Aim24 localizes to the mitochondrial IM and is required for the integrity of the MICOS complex. Studies with yeast Aim24 deletion mutants revealed that this gene is required for respiratory growth, stability of ETC supercomplexes and mitochondrial ultrastructure [64,65]. Whereas mitochondria from cells lacking Aim24 do not manifest an altered cardiolipin composition, when Aim24 deletion is combined with subtle modifications (appending a His-Tag sequence) to other MICOS proteins (MIC12 or MIC26), an altered cardiolipin acyl chain pattern is observed, with a shift toward longer, more saturated acyl chains.…”

Section: Protein Modulators Of Crista Membrane Structure and Cardmentioning

confidence: 99%

Cardiolipin and mitochondrial cristae organization

Ikon¹,

Ryan²

2017

Biochimica et Biophysica Acta (BBA) - Biomembranes

245

230

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A fundamental question in cell biology, under investigation for over six decades, is the structural organization of mitochondrial cristae. Long known to harbor electron transport chain proteins, crista membrane integrity is key to establishment of the proton gradient that drives oxidative phosphorylation. Visualization of cristae morphology by electron microscopy / tomography has provided evidence that cristae are tube-like extensions of the mitochondrial inner membrane (IM) that project into the matrix space. Reconciling ultrastructural data with the lipid composition of the IM provides support for a continuously curved cylindrical bilayer capped by a dome-shaped tip. Strain imposed by the degree of curvature is relieved by an asymmetric distribution of phospholipids in monolayer leaflets that comprise cristae membranes. The signature mitochondrial lipid, cardiolipin (∼18 % of IM phospholipid mass), and phosphatidylethanolamine (34 %) segregate to the negatively curved monolayer leaflet facing the crista lumen while the opposing, positively curved, matrix-facing monolayer leaflet contains predominantly phosphatidylcholine. Associated with cristae are numerous proteins that function in distinctive ways to establish and/or maintain their lipid repertoire and structural integrity. By combining unique lipid components with a set of protein modulators, crista membranes adopt and maintain their characteristic morphological and functional properties. Once established, cristae ultrastructure has a direct impact on oxidative phosphorylation, apoptosis, fusion / fission as well as diseases of compromised energy metabolism.

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Section: Protein Modulators Of Crista Membrane Structure and Cardmentioning

confidence: 99%

Cardiolipin and mitochondrial cristae organization

Ikon¹,

Ryan²

2017

Biochimica et Biophysica Acta (BBA) - Biomembranes

245

230

View full text Add to dashboard Cite

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“…MICOS has also been implicated in cardiolipin biogenesis and maturation. Destabilization of MICOS in cells lacking Aim24, a Mic10 interactor of unknown function, causes alterations in cristae architecture and loss of tafazzin, leading to a non‐native cardiolipin acylation pattern . Tafazzin is a transacylase that exchanges cardiolipin acyl groups depending on membrane curvature and resulting tension in the bilayer, thereby generating the species‐specific acyl composition of cardiolipin that is best suited thermodynamically for the respective inner membrane architecture .…”

Section: Nonbilayer‐forming Phospholipidsmentioning

confidence: 99%

Shaping the mitochondrial inner membrane in health and disease

et al. 2020

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Colina-Tenorio L, Horten P, Pfanner N, Rampelt H (University of Freiburg, Freiburg, Germany). Shaping the mitochondrial inner membrane in health and disease (Review Symposium). J Intern Med 2020; 287: 645-664.Mitochondria play central roles in cellular energetics, metabolism and signalling. Efficient respiration, mitochondrial quality control, apoptosis and inheritance of mitochondrial DNA depend on the proper architecture of the mitochondrial membranes and a dynamic remodelling of inner membrane cristae. Defects in mitochondrial architecture can result in severe human diseases affecting predominantly the nervous system and the heart. Inner membrane morphology is generated and maintained in particular by the mitochondrial contact site and cristae organizing system (MICOS), the F 1 F o -ATP synthase, the fusion protein OPA1/Mgm1 and the nonbilayer-forming phospholipids cardiolipin and phosphatidylethanolamine. These protein complexes and phospholipids are embedded in a network of functional interactions. They communicate with each other and additional factors, enabling them to balance different aspects of cristae biogenesis and to dynamically remodel the inner mitochondrial membrane. Genetic alterations disturbing these membrane-shaping factors can lead to human pathologies including fatal encephalopathy, dominant optic atrophy, Leigh syndrome, Parkinson's disease and Barth syndrome.

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“…PRwf-1, P. glacincola BNF20 would belong to group I, which contains a gene encoding a protein exhibiting the AIM24 domain, also found in the P. glacincola BNF20 TIGR00266 protein. Although no role has been ascribed to it in prokaryotes, in higher organisms it is an internal membrane protein related to mitochondrial biogenesis which is required for yeast respiration (Deckers et al, 2014). The AIM24 domain exhibits a double beta-helix folding, which is frequently found in genes neighboring TerD, suggesting that both proteins could interact (Anantharaman et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Peer Review #1 of "Comparative genomic analysis of a new tellurite-resistant Psychrobacter strain isolated from the Antarctic Peninsula (v0.3)"

2018

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The Psychrobacter genus is a cosmopolitan and diverse group of aerobic, cold-adapted, Gram-negative bacteria exhibiting biotechnological potential for low-temperature applications including bioremediation. Here, we present the draft genome sequence of a bacterium from the Psychrobacter genus isolated from a sediment sample from King George Island, Antarctica (3,490,622 bp; 18 scaffolds; G + C = 42.76%). Using phylogenetic analysis, biochemical properties and scanning electron microscopy the bacterium was identified as Psychrobacter glacincola BNF20, making it the first genome sequence reported for this species. P. glacincola BNF20 showed high tellurite (MIC 2.3 mM) and chromate (MIC 6.0 mM) resistance, respectively. Genome-wide nucleotide identity comparisons revealed that P. glacincola BNF20 is highly similar (>90%) to other uncharacterized Psychrobacter spp. such as JCM18903, JCM18902, and P11F6. Bayesian multi-locus phylogenetic analysis showed that P. glacincola BNF20 belongs to a polyphyletic clade with other bacteria isolated from Polar Regions. A high number of genes related to metal(loid) resistance were found, including tellurite resistance genetic determinants located in two contigs: Contig LIQB01000002.1 exhibited 5 ter genes, each showing putative promoter sequences (terACDEZ), whereas contig LIQB1000003.2 showed a variant of the terZ gene. Finally, investigating the presence and taxonomic distribution of ter genes in the NCBI´s RefSeq bacterial database (5,398 genomes, as January 2017), revealed that 2,623 (48.59%) genomes showed at least one ter gene. At the family level, most (68.7%) genomes harbored one ter gene and 15.6% exhibited five (including P. glacincola BNF20). Overall, our results highlight the diverse nature (genetic and geographic diversity) of the

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Aim24 stabilizes respiratory chain supercomplexes and is required for efficient respiration

Cited by 17 publications

References 49 publications

Cardiolipin and mitochondrial cristae organization

Cardiolipin and mitochondrial cristae organization

Shaping the mitochondrial inner membrane in health and disease

Peer Review #1 of "Comparative genomic analysis of a new tellurite-resistant Psychrobacter strain isolated from the Antarctic Peninsula (v0.3)"

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