AIE-MOF materials for biological applications

Mehmood, Tahir; Reddy, J. Prakasha

doi:10.1016/bs.pmbts.2021.06.013

Cited by 7 publications

(9 citation statements)

References 65 publications

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“…For example, to achieve a high-efficiency ligand-based LMOF phosphor, judicious design of the ligand is of paramount importance. Organic ligands based on AIE 71 are specifically one of the main proponents for inducing tunable and high luminescence in MOFs. Rigid ligands with considerable π electron density have limited molecular rotations and exhibit unique fluorescence properties due to distinct energy conformations in porous space.…”

Section: Luminescent Mofs (Lmofs) As “New-generation” Smart Phosphorsmentioning

confidence: 99%

Luminescent MOFs (LMOFs): recent advancement towards a greener WLED technology

Karmakar

2022

Chem. Commun.

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Section: Luminescent Mofs (Lmofs) As “New-generation” Smart Phosphorsmentioning

confidence: 99%

Luminescent MOFs (LMOFs): recent advancement towards a greener WLED technology

Karmakar

2022

Chem. Commun.

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“…Previous works have manifested that the typical AIE activity materials can be summarized as polyaryl-substituted heterocyclic compounds, intramolecular charge-transfer compounds, hydrogen bond-containing compounds and polymers, and the reported AIE activity mechanisms refer to the steric hindrance effect of the polymer chain, degrees of polymerization, structural stability without spacing distortions, and so forth. − Although the PLQY measurement is an accurate method to reflect the AIE activity of Eu-MOFs, this measurement method is still complex and needs an expensive testing instrument. In order to make a thorough inquiry into the AIE activity mechanism of Eu-MOFs precisely and simplify the measurement method, it is necessary to screen out reliable and direct evaluation standards derived from the corresponding optical properties of Eu-MOFs.…”

Section: Resultsmentioning

confidence: 99%

“…Metal–organic frameworks (MOFs), which consist of metal nodes and organic ligands, exhibit a series of excellent physical–chemical–biological properties. − For instance, rare-earth-based (Eu, Tb, Gd, etc.) MOFs reveal abundant structural diversity, versatile surface chemistry, low toxicity, high stability without photobleaching, multi-emission characteristic peaks, and good bio-compatibility. , Recently, MOFs with aggregation-induced emission (AIE) activity further show the potential application advantages in the fields of energy, information, electronic, and biomedical technologies. , Generally, these MOFs with AIE activity possess several characteristics: (1) the emission intensity increases with the concentration, especially in the solid state (powder or high-concentration solution); (2) high sensitivity in the solid or high-concentration solution state; (3) high-resolution in cell imaging and related biological imaging technology; and (4) controllable emission characteristics by chemical modification based on metal nodes or organic ligands . Furthermore, recent works also reported that the AIE activity of MOFs is significantly affected by the solvent, anion, and cation; thus, MOFs could be used to identify these solvents and ions. ,, Besides, it is necessary to investigate the various mechanisms of MOFs in various solvents to obtain a high AIE activity of Eu-MOFs, which could be suitable for screen-printing.…”

Section: Introductionmentioning

confidence: 99%

“…5,6 Recently, MOFs with aggregation-induced emission (AIE) activity further show the potential application advantages in the fields of energy, information, electronic, and biomedical technologies. 7,8 Generally, these MOFs with AIE activity possess several characteristics: (1) the emission intensity increases with the concentration, especially in the solid state (powder or highconcentration solution); (2) high sensitivity in the solid or high-concentration solution state; (3) high-resolution in cell imaging and related biological imaging technology; and (4) controllable emission characteristics by chemical modification based on metal nodes or organic ligands. 9 Furthermore, recent works also reported that the AIE activity of MOFs is significantly affected by the solvent, anion, and cation; thus, MOFs could be used to identify these solvents and ions.…”

Section: ■ Introductionmentioning

confidence: 99%

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Enhanced Aggregation-Induced Emission Activity of Metal–Organic Frameworks by Using Machine Learning Technology

Zhang

Tao

Tang

et al. 2022

ACS Sustainable Chem. Eng.

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Metal−organic frameworks (MOFs) with aggregation-induced emission (AIE) activity show a high emission intensity, high sensitivity, and high resolution in biological imaging and identification technologies. However, their AIE activity is controlled by various Eu precursors' components and synthesis process parameters, and traditional research methods are hard to deal with these complex multiple parameter systems. In this work, we utilize two machine learning technologies to optimize the synthesis process parameters of Eu-MOFs and analyze their synthesis mechanism. First, we choose gradient boosting decision tree (GBDT) regression as the best fitting model. Second, on the basis of the SHapley Additive exPlanation (SHAP) calculation method with the PL/UV intensity ratio regarded as the evaluation standard, we demonstrate that the Eu-precursor concentration (1.91 × 10 7 ) and synthesis time (1.73 × 10 7 ) dominate in the synthesis systems. Meanwhile, these two parameters show synergic and antagonistic effects on the PL/UV intensity ratio, respectively. Finally, we employ a greedy random walk method to work out that "142-0.83-4.1" should be the best optimization process parameters, and the corresponding sample shows a high photoluminescence quantum yield (PLQY) with a value of 7.65% in the solid state. More importantly, the screen-printed pattern exhibits bright red fluorescence under UV light.

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“…Recently, the aggregation‐induced emission (AIE) characteristic metal‐organic frameworks (MOFs) exhibit a huge potential application in the fields of energy, information, electronic, and biomedical technology. [ 1–4 ] Expecting for the abundant structural diversity, versatile surface chemistry, high stability and low toxicity and good biocompatibility, AIE characteristic MOFs further reveal an high emission intensity, sensitivity and high‐resolution, especially in the solid state or high concentration liquid states. [ 5–7 ] Dong et al.…”

Section: Introductionmentioning

confidence: 99%

Size‐Controllable Eu‐MOFs through Machine Learning Technology: Application for High Sensitive Ions and Small‐Molecular Identification

et al. 2022

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high-resolution, especially in the solid state or high concentration liquid states. [5][6][7] Dong et al. constructed two Ln-MOFs {[Ln(H 3 L)(H 2 O)] • 7H 2 O} n (Ln = Eu and Tb, H 3 L = 5-(3',5'-dicarboxylphenyl)picolinic acid), and utilized these two kinds of Ln-MOFs to detect the Fe 3+ and chromate ions. [8] And the detection limits of Fe 3+ / CrO 4 2-/Cr 2 O 7 2are 0.67/0.53/0.32 × 10 −6 m for europium-based metal-organic frameworks (Eu-MOFs) and 1.26/0.75/0.57 × 10 −6 m for Tb-MOFs, respectively. Cui et al. synthesized the functional Eu-MOFs by selecting Eu 3+ and 5-boronobenzene-1,3-dicarboxylic acid (BBDC) as metal node and organic ligand, respectively. [9] Due to the special nucleophilic reaction between H 2 O 2 and boric group, these Eu-MOFs can be used to detect the concentration of H 2 O 2 and glucose, and their low detection limit concentrations are 0.0335 × 10 −6 and 0.0643 × 10 −6 m, respectively. Zhang et al. also synthesized five kinds of 3D Ln-MOFs as [Ln 4 (µ 6 -L) 2 (µ-HCOO)(µ 3 -OH)3(µ 3 -O) (DMF)2(H 2 O) 4 ] n (Ln = Tb, Eu, Gd, Dy, and Er), and reflected that Tb-MOFs showed an high efficiency and selectivity in detecting the acetone and metal (III) cations (Fe 3+ and Ce 3+ ). [10] Expecting for the effect of precursors components (such as rare-salt, organic ligand, solvent and their composition ratio, etc.) discussed above, the morphology and size of MOFs also reported to have an significant influence on the optical properties of AIE characteristic MOFs. [11][12][13] For instance, the size of MOFs not only affects their specific surface area and reaction Metal-organic frameworks (MOFs) with the aggregation-induced emission (AIE) activities exhibit potential applications in the fields of energy and biomedical technology. However, the controllable synthesis of MOFs in the varied particle sizes not only affects their AIE activities, but also restricts their application scenarios. In this work, the varied particle sizes of Eu-MOFs are synthesized by adjusting the synthesis process parameters, and their variation rules combining the single factor analysis method with machine learning technology are studied. Based on the R 2 score, the gradient boosting decision tree (GBDT) regression model (0.9535) is employed to calculate the weight and correlation between different synthesis process parameters and it is shown that all these parameters have synergic effects on the particle sizes of Eu-MOFs, and the Eu-precursors concentration dominates in their synthesis process. Furthermore, it is indicated that the large size of Eu-MOFs and strong structural stability contribute to their high AIE activities. Finally, a screen-printed pattern is fabricated using the sample of "120-0.3-6," and this pattern exhibits a bright red fluorescence under the UV light. More importantly, this kind of Eu-MOFs can also be used to identify varied ions (Fe 3+ , F -, I -, SO 4 2-, CO 3 2-, and PO 4 3-) and citric acid.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002...

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AIE-MOF materials for biological applications

Cited by 7 publications

References 65 publications

Luminescent MOFs (LMOFs): recent advancement towards a greener WLED technology

Luminescent MOFs (LMOFs): recent advancement towards a greener WLED technology

Enhanced Aggregation-Induced Emission Activity of Metal–Organic Frameworks by Using Machine Learning Technology

Size‐Controllable Eu‐MOFs through Machine Learning Technology: Application for High Sensitive Ions and Small‐Molecular Identification

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