The predictors for seeking alternative therapies for HIV-infection in sub-Saharan Africa are unknown. Among a prospective cohort of 442 HIV-infected patients in Moshi, Tanzania, 249 (56%) sought cure from a newly popularized religious healer in Loliondo (450 kilometers away), and their adherence to antiretrovirals (ARVs) dropped precipitously (OR=0.20, 95% CI, 0.09–0.44, p<0.001) following the visit. Compared to those not attending Loliondo, attendees were more likely to have been diagnosed with HIV more remotely (3.8 vs. 3.0 years prior, p<0.001), have taken ARVs longer (3.4 vs. 2.5 years, p<0.001), have higher median CD4+ lymphocyte counts (429 vs. 354 cells/mm3, p<0.001), be wealthier (wealth index 10.9 vs. 8.8, p = 0.034), and receive care at the private versus the public hospital (p=0.012). In multivariable logistic regression, only years since the start of ARVs remained significant (OR, 1.49, 95% CI, 1.23–1.80). Treatment fatigue may play a role in the lure of alternative healers.