AIDS-related lymphoma screen results and molecular structure determination of a new crown ether bearing aziridinylcyclophosphazene, potentially capable of ion-regulated DNA cleavage action

Brandt, K.; Kruszyński, Rafał; Bartczak, Tadeusz J.; Porwolik-Czomperlik, Iwona

doi:10.1016/s0020-1693(01)00557-6

Cited by 102 publications

(43 citation statements)

References 34 publications

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“…The aziridine-, spermine-and spermidine-substituted cyclotriphosphazenes were found to be very effective in different tumor cells [18][19][20]. For example, it was found that spermine-bonded cyclotriphosphazenes disclosed cytotoxic activity against HT-29 (human colon adenocarcinoma), Hep2 (human epidermoid larynx carcinoma) and Vero (African green monkey kidney) cells and stimulated apoptosis [20].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, some 1,4-dioxa-8-azaspiro [4,5] decane(DASD)-substituted ferrocenylphosphazenes were found to be effective against HeLa cancer cell lines [21]. In addition, aziridine-crown substituted cyclotriphosphazenes, known as the hazardous compounds, cleave the DNA and halt the growth of cancer cells [22]. Also, the Cu+2 complex of fully phenoxysubstituted cyclotetraphosphazene was found to be alive in the oxidative cleavage of DNA [23].…”

Section: Introductionmentioning

confidence: 99%

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Phosphorus–nitrogen compounds: part 30. Syntheses and structural investigations, antimicrobial and cytotoxic activities and DNA interactions of vanillinato-substituted NN or NO spirocyclic monoferrocenyl cyclotriphosphazenes

et al. 2014

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The gradual Cl replacement reactions of NN (1-3) or NO spirocyclic monoferrocenyl cyclotriphosphazenes (4 and 5) with the potassium salt of 4-hydroxy-3-methoxybenzaldehyde (potassium vanillinate) resulted in the mono (1a-5a), geminal (gem-1b-5b), non-geminal (cis-5b and trans -1b-4b), tri (1c, 3c-5c) and tetra-vanillinato-substituted phosphazenes (1d-5d). All the phosphazene derivatives have stereogenic P-center(s), except tetra-substituted ones. The vanillinatophosphazenes have reversible voltammograms with one-electron anodic and cathodic peaks which are attributed to ferrocenyl redox probe. The structures of the new phosphazene compounds were determined by FTIR, MS, (1)H, (13)C{(1)H} and (31)P{(1)H} NMR spectral data. The solid-state structure of cis -5b was examined by single-crystal X-ray diffraction techniques. In addition, the compounds were tested in HeLa cancer cell lines using MTT assay. The 12 phosphazene derivatives were screened for antimicrobial activity, and 3c was very effective against S. aureus even at 4.88 µM concentration, taking into account the MIC values. Besides, interactions between the phosphazenes and pBR322 plasmid DNA were also investigated.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phosphorus–nitrogen compounds: part 30. Syntheses and structural investigations, antimicrobial and cytotoxic activities and DNA interactions of vanillinato-substituted NN or NO spirocyclic monoferrocenyl cyclotriphosphazenes

et al. 2014

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“…Knowledge of the thermodynamic functions for crown ether complex formation with cations or organic molecules in various pure or mixed solvents may be used in model planning of various processes such as extraction or drug design [7,8]. Many data concerning the complex formation process in non-aqueous solvents and mixed solvent systems can be found in the literature [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Thermodynamics of ZrO2+ cation complexation with dibenzo-18-crown-6 in mixed non-aqueous solvents

Rounaghi

Deiminiat

Tarahomi

2011

J Incl Phenom Macrocycl Chem

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The complexation reaction of dibenzo-18-crown-6 (DB18C6) with ZrO 2? cation was studied in some binary solvent solutions of acetonitrile (AN), 1,2 dichloroethane (DCE), nitromethane (NM) and ethylacetate (EtOAc) with methanol (MeOH), at different temperatures by conductometry method. The stability constant of the resulting 1:1 complex at each temperature was determined using a computer fitting conductance-mole ratio data. The results revealed that, the (DB18C6ÁZrO) 2? complex is more stable in the EtOAcMeOH binary mixed solvents compared with the other binary mixed solvent solutions. A non-linear relationship was observed for changes of log K f of (DB18C6ÁZrO) 2? complex versus the composition of the binary mixed solvents. The corresponding standard thermodynamic parameters (DH c°, DS c°) were obtained from temperature dependence of the stability constant. The results show that the (DB18C6ÁZrO) 2? complex is enthalpy destabilized but entropy stabilized and the values along with the sign of these parameters are influenced by the nature and composition of the mixed solvents.

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“…Phosphazenes, which are the best known and most intensively studied phosphorusnitrogen compounds [1][2][3][4][5], possess a number of characteristics such as biomedical properties and applications due to their strong antitumor activity [6][7][8][9][10][11]. Their antimicrobial and biological activities on bacterial and yeast cells have been studied [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of oxime‐bearing hexakis(2‐formylphenoxy)‐phosphazene and its derivatives

Pamukçi

Cil

Begeç

et al. 2007

Heteroatom Chemistry

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AIDS-related lymphoma screen results and molecular structure determination of a new crown ether bearing aziridinylcyclophosphazene, potentially capable of ion-regulated DNA cleavage action

Cited by 102 publications

References 34 publications

Phosphorus–nitrogen compounds: part 30. Syntheses and structural investigations, antimicrobial and cytotoxic activities and DNA interactions of vanillinato-substituted NN or NO spirocyclic monoferrocenyl cyclotriphosphazenes

Phosphorus–nitrogen compounds: part 30. Syntheses and structural investigations, antimicrobial and cytotoxic activities and DNA interactions of vanillinato-substituted NN or NO spirocyclic monoferrocenyl cyclotriphosphazenes

Thermodynamics of ZrO2+ cation complexation with dibenzo-18-crown-6 in mixed non-aqueous solvents

Synthesis and characterization of oxime‐bearing hexakis(2‐formylphenoxy)‐phosphazene and its derivatives

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