This review covers the research on the anticonvulsant properties of marketed drugs with their side effects and adverse drug reactions and the importance of medicinal plants and homeopathic medications in the treatment of epilepsy with the mechanism of actions with fewer side effects in comparison to allopathic medications that cause side effects which may be dangerous in some situations so to overcome these problem Ayurveda and homeopathy plays a major role. The new advancement in the management and cure of epilepsy with the help of several newly discovered compounds that are more advanced than the marketed drugs which are under clinical trials and have fewer side-effects than existing drugs and in coming years these compounds will be part of epileptic drugs. Development of the animal epilepsy model with the help of AI techniques to reduce the failure of the model, AI is a useful tool in drug discovery and can evaluate vast data easily and is a time-consuming technique.
INTRODUCTION: Retrospective and Prospective Status of Epilepsy:The world scenario "Health for all" is an internationally accepted goal 1 . The impact of the rapidly transforming world is so complex that every phenomenon is entangled with the other and is impacted by its surroundings and social determinants 2 . Anticonvulsant agents are medications that show their effect on epileptic patients by preventing seizures in a particular dosage form and do not considerably affect the level of cognition. This review focuses on the effect of anticonvulsive agents on epilepsy and medicinal properties and clinical use of first, second, and third-generation antiepileptic drugs.