“…In other studies, cytoplasmic tubular structures were not detected in hepatocytes of patients with non-A, non-B hepatitis [Gmelin et al, 1980;Bamber et al, 1981;Cabral et al, 1981;Gibo et al, 1982;Kunze et al, 19821. However, cytoplasmic tubular alterations similar to those observed in chimpanzees with non-A, non-B hepatitis have been found in lymph nodes, lymphocytes, monocytes, and tissue macrophages of patients with the acquired immune deficiency syndrome [Sidhu et al, 1983;Schaf et al, 1983;Orenstein, 1983;Ewing et at, 19831 and in circulating lymphocytes and lymph nodes of patients with persistent lymphadenopathy and the acquired immune deficiency syndrome [Anderson et al, 19841. Several laboratories have also reported virus-like particles in liver biopsies of patients with non-A, non-B hepatitis. Intracellularly, clusters consisting of 20-40 nm electron-dense particles were visualised in the nuclei of hepatocytes of chimpanzees infected with non-A, non-B hepatitis.…”