Aids-Associated Ultrastructural Changes

Schaff, Zsuzsa; Tabor, Edward; Jackson, DanielR.; Rj, Gerety

doi:10.1016/s0140-6736(83)92447-9

Cited by 23 publications

(4 citation statements)

References 7 publications

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“…All these findings taken together may suggest that the hyperplastic lesions present in nodes of drug abusers with LAS undergo regressive changes which may finally lead to the lymphoid depletion and fibrosis of advanced AIDS (Reichert et al 1983). This suggestion is also supported by the presence of anti-HTLV 3 antibodies in all cases in which the test has been carried out, and by the ultrastructural demonstration of viruslike bodies in lymph node cells and in the intercellular space, similar to those observed in LAS of homosexuals and in AIDS (Anderson et al 1984, Ewing et al 1983, Orenstein 1984, Schaff et al 1983, Sidhu et al 1983.…”

Section: Discussionmentioning

confidence: 78%

Systemic lymphadenopathy (LAS) in intravenous drug abusers. Histology, immunohistochemistry and electron microscopy: pathogenic correlations

Baroni¹,

Pezzella²,

Stoppacciaro³

et al. 1985

Histopathology

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In the present study we have evaluated the histological, immunohistochemical, ultrastructural and cell surface phenotypic features of lymph nodes from 19 intravenous drug abusers and two homosexual men with persistent lymphadenopathy syndrome and from six control patients. Our investigation has demonstrated that the lymphadenopathy of drug abusers is characterized by: (a) specific histological features with evidence of evolution from an initial hyperplastic-reactive to a late regressive-destructive stage; (b) T-cell surface phenotype distribution similar to that in the peripheral blood of homosexuals; (c) peculiar infiltration of the germinal centres by T8+ cells and by S-100+, T6+ interdigitating reticulum-like cells; (d) electron microscopic features indicating the presence of virus bodies in lymph node cells and in the intercellular spaces. These data suggest that the lymphadenopathy of drug abusers and homosexuals are similar pathological conditions with characteristic features which allow histological differentiation of this entity from those found in other viral infections.

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Section: Discussionmentioning

confidence: 78%

Systemic lymphadenopathy (LAS) in intravenous drug abusers. Histology, immunohistochemistry and electron microscopy: pathogenic correlations

Baroni¹,

Pezzella²,

Stoppacciaro³

et al. 1985

Histopathology

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“…In other studies, cytoplasmic tubular structures were not detected in hepatocytes of patients with non-A, non-B hepatitis [Gmelin et al, 1980;Bamber et al, 1981;Cabral et al, 1981;Gibo et al, 1982;Kunze et al, 19821. However, cytoplasmic tubular alterations similar to those observed in chimpanzees with non-A, non-B hepatitis have been found in lymph nodes, lymphocytes, monocytes, and tissue macrophages of patients with the acquired immune deficiency syndrome [Sidhu et al, 1983;Schaf et al, 1983;Orenstein, 1983;Ewing et at, 19831 and in circulating lymphocytes and lymph nodes of patients with persistent lymphadenopathy and the acquired immune deficiency syndrome [Anderson et al, 19841. Several laboratories have also reported virus-like particles in liver biopsies of patients with non-A, non-B hepatitis. Intracellularly, clusters consisting of 20-40 nm electron-dense particles were visualised in the nuclei of hepatocytes of chimpanzees infected with non-A, non-B hepatitis.…”

Section: Introductionmentioning

confidence: 99%

Intracytoplasmic inclusions in human hepatocytes in non‐A, non‐B hepatitis: An ultrastructural study

Tf¹,

Tovey²,

Mg³

et al. 1984

Journal of Medical Virology

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An ultrastructural study was carried out on 114 liver biopsies obtained for diagnostic purposes from patients with various pathological disorders of the liver including hepatitis B-related liver disease, non-A, non-B hepatitis, alcoholic liver disease, fatty change, and cryptogenic cirrhosis. The opportunity was taken to evaluate the significance of intracytoplasmic crystalline structures found in the hepatocytes of nine patients with a variety of liver disorders. The cytoplasmic inclusions varied in size up to 2 microns in length and shape and were not limited by membranes. The presence of these inclusions cannot, however, be correlated either specifically with non-A, non-B hepatitis or with other known nonviral liver disease. The functional, physiological, and pathological significance of the crystalline structures remain to be elucidated.

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“…Continuity between TRS and TRF has been seen (Fig. llc), and both are probably the result of membrane proliferation, perhaps caused by viral infection or other stimulation (Feremans et al, 1983;Hammar et al, 1984;Kostianovsky et al, 1984;Schaff et al, 1983).…”

Section: Virus-like Structures Described In Aids Patientsmentioning

confidence: 92%

“…The most frequently reported observation has been of tubuloreticular structures (TRS) or tubulorecticular inclusions (TRD see Tucker, pp. 137-158), seen mainly in lymphocytes (Feremans et al, 1983;Orenstein, 1983;Schaff et al, 1983;Schenk et al, 1986;Sidhu et al, 1983;Thune et al, 1983;Watanabe et al, 1984;Zucker-Franklin, 1983), but also in the choroid of the eye (Jensen, 19851, endothelial cells in Kaposi's sarcoma, and fibroblasts (Zucker-Franklin, 1985). These "wormlike" inclusions resemble nucleocapsids of myxoviruses, though TRS are slightly larger in diameter (25 nm vs. 9-18 nm) ( Fig.…”

Section: Virus-like Structures Described In Aids Patientsmentioning

confidence: 99%

Viral infections in the acquired immunodeficiency syndrome

Miller

Howell

1988

J. Elec. Microsc. Tech.

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The following communication is a tripartite synopsis of the role of viral infection in the acquired immunodeficiency syndrome (AIDS). The first section describes the impact of viral opportunistic infection in AIDS; for each virus, clinical presentation and diagnosis, laboratory diagnostic approaches (with emphasis on electron microscopy), and therapeutic interventions attempted to date are discussed. The second segment explores current theories on the pathogenesis of AIDS, and describes diagnostic and therapeutic approaches to the syndrome itself. The final section catalogues ultrastructural anomalies in the cells of AIDS patients, many of which have been mistakenly identified as etiologic agents.

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Aids-Associated Ultrastructural Changes

Cited by 23 publications

References 7 publications

Systemic lymphadenopathy (LAS) in intravenous drug abusers. Histology, immunohistochemistry and electron microscopy: pathogenic correlations

Systemic lymphadenopathy (LAS) in intravenous drug abusers. Histology, immunohistochemistry and electron microscopy: pathogenic correlations

Intracytoplasmic inclusions in human hepatocytes in non‐A, non‐B hepatitis: An ultrastructural study

Viral infections in the acquired immunodeficiency syndrome

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