AIDS-associated non-Hodgkin lymphoma

Beral, Valerie; Peterman, ThomasA.; Berkelman, Ruth L.; Jaffe, Harold W.

doi:10.1016/0140-6736(91)92513-2

Cited by 588 publications

(258 citation statements)

References 12 publications

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“…Lymphomas in transplanted patients under immunosuppressive treatment are generally of highgrade morphology and are often extranodal (Starzl et al, 1984). This is also characteristic of AIDS-associated lymphomas in which immunosuppression is considered to be an important determinant of the increased risk (Beral et al, 1991). The present results also raise the possibility that immunosuppression caused by transfusions may also increase the risk of high-grade extranodal lymphomas.…”

Section: Discussionsupporting

confidence: 64%

Blood transfusion as a risk factor for non-Hodgkin lymphoma

Brandt

Brandt²,

Olsson³

et al. 1996

Br J Cancer

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Summary In a case-control study of 280 out of 426 consecutive patients with a recent diagnosis of nonHodgkin lymphoma (NHL) and 1827 control subjects, 53 (19%) and 230 (13%) respectively had received blood transfusions 1 year or more before the interview. Using an age-and sex-stratified analysis the odds ratio (OR) for transfusion was 1.74 (95% CI 1.24-2.44). ORs were also determined for transfusions received in the intervals 1 -5, 6 -15, 16-25 and > , Carli et al., 1994, Cartwright et al., 1994, National Board of Health and Welfare, 1995. The causes of this increase are unknown, and in an attempt to identify risk factors for NHL a case-control study has been initiated in the Southern Health Care Region of Sweden.According to cohort studies of cancer morbidity in blood recipients, transfusions may be a risk factor for NHL. In a Swedish study (Blomberg et al., 1993) an excess of NHL was observed in previously transfused subjects, the standardised morbidity ratio being 4.09 (95% CI 1.65-8.43). Cerhan et al. (1993) obtained information about past transfusions from women aged 55-69 years who were resident in Iowa and followed up for 5 years. For women who had ever received a blood transfusion the relative risk of NHL was 2.20 (95% CI 1.35-3.58). Memon and Doll (1994) identified nearly 13 000 infants who received blood transfusions shortly after birth in England, Wales and Scotland and recorded the incidence of subsequent malignant tumours. The incidence of NHL at 15-49 years of age was about twice that expected, but the excess was not statistically significant.Our ongoing case-control study offered an opportunity to further evaluate the relation between previous blood transfusions and the development of NHL. We report here on the association between transfusions and NHL. The relation between the time lapse since transfusion and the risk of lymphoma has also been studied. Subjects and methods

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Section: Discussionsupporting

confidence: 64%

Blood transfusion as a risk factor for non-Hodgkin lymphoma

Brandt

Brandt²,

Olsson³

et al. 1996

Br J Cancer

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“…In our 2 patients, muscle involvement was the first manifestation of an immunoblastic NHL, a type of NHL commonly observed in AIDS (2). In patient I , clusters of lymphoma cells were found within muscle fibers, as previously reported in muscle lymphoma (9), and EBV was detected in tumor cells.…”

Section: Skeletal Muscle Lymphoma In Patients With the Acquired Immunsupporting

confidence: 81%

“…Non-Hodgkin's lymphoma (NHL) is approximately 60 times more frequent in human immunodeficiency virus (HIVhinfected patients than in the general population (2), and extranodal presentation of NHL accounts for 55% of lymphomas in this setting (3). Despite occasional reports on skeletal muscle lymphoma in patients with the acquired immunodeficiency syndrome (AIDS) (3,4), NHL has not been mentioned in reviews on neuromuscular diseases associated with HIV infection (5-7).…”

Section: Skeletal Muscle Lymphoma In Patients With the Acquired Immunmentioning

confidence: 99%

Skeletal muscle lymphoma in patients with the acquired immunodeficiency syndrome: a diagnostic challenge

Chevalier

Amoura

Viard

et al. 1993

Arthritis & Rheumatism

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“…Primary CNS lymphomas constitute approximately 20% to 25% of all HIV-related lymphomas and have a thousandfold increased incidence in AIDS patients, although the incidence has decreased significantly since the introduction of highly active antiretroviral therapy [111,115,120]. These tumors have a tendency to occur late in the course of HIV infection and show EBV association in virtually 100% of the cases [121].…”

Section: Ebv and Hiv-related Lymphoproliferative Disordersmentioning

confidence: 99%