AIDS-associated Nephropathy: 5-year Retrospective Morphologic Analysis of 87 Cases

Soriano-Rosas, Juan; Avila-Casado, M. Carmen; Carrera-González, Ernesto; Chávez-Mercado, Leonora; Cruz-Ortíz, Humberto; Rojo, Julieta

doi:10.1016/s0344-0338(98)80046-0

Cited by 16 publications

(9 citation statements)

References 9 publications

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“…In an autopsy study in India [2,34], 24 of 35 kidneys from patients who died of AIDS showed evidence of infection, including 17 cases of tuberculosis. In a similar study in Mexico City, renal disease was demonstrable in 87 of 138 (63 %) autopsies on AIDS patients: infection was the cause of the renal disease in 36 cases, with 19 being due to M. tuberculosis [2,35].…”

Section: Renal Tb In Immunocompromised Patientsmentioning

confidence: 99%

Multidetector CT in Renal Tuberculosis

Sankhe

Joshi

2014

Curr Radiol Rep

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Tuberculosis (TB) is one of the commonest infectious diseases in the developing countries with rising incidence seen due to HIV and AIDS. Pulmonary tuberculosis is the commonest form seen. Renal Tuberculosis is the most common extrapulmonary form. There are no specific clinical symptoms associated with renal tuberculosis. The constitutional symptoms like low grade fever, weight loss, anorexia commonly seen with pulmonary TB are not usually seen with renal TB. Renal TB is also cause of interstitial nephritis which leads to end-stage renal failure. Hence the role of radiologist assumes importance in supporting the timely diagnosis although cultures or histologic analysis is required for definitive diagnosis. The individual imaging finding may not be diagnostic as it can be seen with other renal pathologies too, however, presence of multiple imaging findings in a single case is pointer to this disease. Renal TB involves both cortex and collecting system. This article gives review of pathophysiology and computed tomography features of Renal TB.

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Section: Renal Tb In Immunocompromised Patientsmentioning

confidence: 99%

Multidetector CT in Renal Tuberculosis

Sankhe

Joshi

2014

Curr Radiol Rep

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“…4 In one study, renal disease was demonstrable in 87 of 138 autopsies on AIDS patients; infection was the cause of the renal disease in 36 cases, with 19 being due to Mycobacterium tuberculosis. 27 In a similar study, Nourse et al examined whether tuberculosis may play a role in renal disease in HIVinfected children. Twelve renal biopsies or postmortem examinations showed that, in 4 cases, biopsy findings were consistent with tuberculous involvement.…”

Section: Histopathological Datamentioning

confidence: 99%

Kidney and Tuberculosis

Zümrütdal

2013

Nephrology Research & Reviews

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Genitourinary tuberculosis is the second most common form of extrapulmonary tuberculosis after lymph node involvement. It can involve any part of the genitourinary system and presentation may vary from vague urinary symptoms to chronic kidney disease. The kidney is usually the primary organ infected in the genitourinary system and renal involvement of tuberculosis often does not present with classic symptoms of fever, weight loss, or night sweats. Tuberculosis of the urinary tract is, therefore, easily overlooked. In patients with a diagnosis of genitourinary tuberculosis, only 10% show signs of active pulmonary tuberculosis and the latency period between the initial tuberculosis infection and diagnosis with renal disease may be as long as 5-40 years. Direct infection of the kidney and lower urinary tract, and secondary amyloidosis are major forms of well-documented renal involvement. However, in recent years, an increasing number of data have reported that, independent of drug therapy, tuberculosis itself can cause glomerular and tubulointerstitial lesions, and patients may present with either acute or chronic renal failure with proteinuria. The most frequent renal biopsy finding in patients with renal involvement is chronic tubulointerstitial nephritis. Progression to end-stage renal failure may be higher than currently believed because there is little evidence as to the extent to which tuberculosis is a cause of end-stage renal failure worldwide. Tuberculosis should be considered as a possible origin of both acute and chronic renal failure, especially in countries where the incidence of tuberculosis is high. Timely diagnosis and treatment may prevent acute forms of renal disease and late sequelae of pulmonary tuberculosis. Kidney biopsy should be considered in the clinical evaluation of kidney dysfunction with tuberculosis and also in cases with unusual presentations

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“…In an autopsy study in India, 24 of 35 kidneys from patients who died of AIDS showed evidence of infection, including 17 cases of TB [2]. In a similar study in Mexico City, renal disease was demonstrable in 87 (63%) of 138 autopsies performed on patients with AIDS; infection was the cause of the renal disease in 36 cases, with 19 being due to Mycobacterium tuberculosis [3]. However, no data of the prevalence of genitourinary TB in living patients with AIDS can be found in the literature.…”

Section: A Simple Algorithm For the Diagnosis Of Aids-associated Genimentioning

confidence: 99%