AIDS and Opportunistic Infections

Çiledağ, Aydın; Karnak, Demet

doi:10.5772/22390

Cited by 3 publications

(2 citation statements)

References 109 publications

(109 reference statements)

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“…It usually includes a poor antibody response due to B cell dysfunction and defects in chemotaxis, phagocytosis, and intracellular killing by monocytes, macrophages, and neutrophils. Impairment of local defenses, manifested by a depression of specific IgA at the mucosal surfaces, also contributes to increased opportunistic infections [ 39 ]. In this study patients with history of opportunistic infections had significantly higher prevalence of elevated liver enzyme.…”

Section: Discussionmentioning

confidence: 99%

Liver Enzymes Abnormalities among Highly Active Antiretroviral Therapy Experienced and HAART Naïve HIV-1 Infected Patients at Debre Tabor Hospital, North West Ethiopia: A Comparative Cross-Sectional Study

Shiferaw

Tulu

Zegeye

et al. 2016

AIDS Research and Treatment

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Liver disease has emerged as the most common non-AIDS-related cause of death in HIV patients. However, there is limited data regarding this condition including our setting in Ethiopia. Hence, liver enzyme abnormalities among highly active antiretroviral therapy (HAART) experienced and HAART naïve patients were assessed in this study. A total of 164 HAART experienced and 164 HAART naïve patients were studied. Blood specimen was collected to determine alanine aminotransferase (ALT) and aspartate aminotransferase (AST), CD4 count, and viral hepatitis. The prevalence of liver enzyme abnormality was 20.1% and 22.0% among HAART experienced and HAART naïve patients, respectively. The HAART experienced patients had higher mean ALT than HAART naïve patients (P = 0.002). Viral hepatitis (AOR = 6.02; 95% CI = 1.87–19.39), opportunistic infections (AOR = 2.91; 95% CI = 1.04–8.19), current CD4 count <200 cells/mm3 (AOR = 2.16; 95% CI = 1.06–4.39), and male sex (AOR = 1.83; 95% CI = 1.001–3.33) were associated with elevated ALT and/or AST. In conclusion, liver enzyme abnormalities were high in both HAART experienced and HAART naïve HIV-1 infected patients. Hence, monitoring and management of liver enzyme abnormalities in HIV-1 infected patients are important in our setting.

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Section: Discussionmentioning

confidence: 99%

Liver Enzymes Abnormalities among Highly Active Antiretroviral Therapy Experienced and HAART Naïve HIV-1 Infected Patients at Debre Tabor Hospital, North West Ethiopia: A Comparative Cross-Sectional Study

Shiferaw

Tulu

Zegeye

et al. 2016

AIDS Research and Treatment

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“…HIV infection is estimated to affect over 35 million people worldwide and can result in acquired immunodeficiency syndrome (AIDS) and the further development of opportunistic infections and cancer [117,118]. HIV infection can also result in a number of comorbidities including inflammation and diarrhea, and studies suggest that gut microbiome dysbiosis is associated with HIV infection [119].…”

Section: Virome-associated Dysbiosismentioning

confidence: 99%

Human Virome and Disease: High-Throughput Sequencing for Virus Discovery, Identification of Phage-Bacteria Dysbiosis and Development of Therapeutic Approaches with Emphasis on the Human Gut

Santiago-Rodríguez

Hollister

2019

Viruses

123

104

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The virome is comprised of endogenous retroviruses, eukaryotic viruses, and bacteriophages and is increasingly being recognized as an essential part of the human microbiome. The human virome is associated with Type-1 diabetes (T1D), Type-2 diabetes (T2D), Inflammatory Bowel Disease (IBD), Human Immunodeficiency Virus (HIV) infection, and cancer. Increasing evidence also supports trans-kingdom interactions of viruses with bacteria, small eukaryotes and host in disease progression. The present review focuses on virus ecology and biology and how this translates mostly to human gut virome research. Current challenges in the field and how the development of bioinformatic tools and controls are aiding to overcome some of these challenges are also discussed. Finally, the present review also focuses on how human gut virome research could result in translational and clinical studies that may facilitate the development of therapeutic approaches.

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Caracterizando al enemigo: Infecciones oportunistas en el sistema nervioso central en pacientes con VIH, una serie de casos colombiana

Castro-Vásquez

Maldonado

Arboleda

et al. 2022

Neurología Argentina

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AIDS and Opportunistic Infections

Cited by 3 publications

References 109 publications

Liver Enzymes Abnormalities among Highly Active Antiretroviral Therapy Experienced and HAART Naïve HIV-1 Infected Patients at Debre Tabor Hospital, North West Ethiopia: A Comparative Cross-Sectional Study

Liver Enzymes Abnormalities among Highly Active Antiretroviral Therapy Experienced and HAART Naïve HIV-1 Infected Patients at Debre Tabor Hospital, North West Ethiopia: A Comparative Cross-Sectional Study

Human Virome and Disease: High-Throughput Sequencing for Virus Discovery, Identification of Phage-Bacteria Dysbiosis and Development of Therapeutic Approaches with Emphasis on the Human Gut

Caracterizando al enemigo: Infecciones oportunistas en el sistema nervioso central en pacientes con VIH, una serie de casos colombiana

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