AICL: a new activation-induced antigen encoded by the human NK gene complex

Hamann, Jörg; Montgomery, Kate; Lau, Shigeko O.; Kucherlapati, Raju; Lier, R. A. W. Van

doi:10.1007/s002510050208

Cited by 51 publications

(45 citation statements)

References 23 publications

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“…For example, the mean expression level of activation-induced C-type lectin (AICL) was threefold higher in AML than ALL, and the absolute mean difference was substantial at 826 units. Considering that AICL is expressed in a variety of hematopoietic-derived cell lines (Hamann et al 1997), one might reasonably conclude that AICL was indeed overexpressed in AML based on this evidence. However, our modeling approach gave AICL a Z-score of 0.91.…”

Section: Discussionmentioning

confidence: 99%

An Efficient and Robust Statistical Modeling Approach to Discover Differentially Expressed Genes Using Genomic Expression Profiles

Thomas¹,

Olson²,

Tapscott³

et al. 2001

Genome Res.

286

192

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We have developed a statistical regression modeling approach to discover genes that are differentially expressed between two predefined sample groups in DNA microarray experiments. Our model is based on well-defined assumptions, uses rigorous and well-characterized statistical measures, and accounts for the heterogeneity and genomic complexity of the data. In contrast to cluster analysis, which attempts to define groups of genes and/or samples that share common overall expression profiles, our modeling approach uses known sample group membership to focus on expression profiles of individual genes in a sensitive and robust manner. Further, this approach can be used to test statistical hypotheses about gene expression. To demonstrate this methodology, we compared the expression profiles of 11 acute myeloid leukemia (AML) and 27 acute lymphoblastic leukemia (ALL) samples from a previous study ) and found 141 genes differentially expressed between AML and ALL with a 1% significance at the genomic level. Using this modeling approach to compare different sample groups within the AML samples, we identified a group of genes whose expression profiles correlated with that of thrombopoietin and found that genes whose expression associated with AML treatment outcome lie in recurrent chromosomal locations. Our results are compared with those obtained using t-tests or Wilcoxon rank sum statistics.

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Section: Discussionmentioning

confidence: 99%

An Efficient and Robust Statistical Modeling Approach to Discover Differentially Expressed Genes Using Genomic Expression Profiles

Thomas¹,

Olson²,

Tapscott³

et al. 2001

Genome Res.

286

192

View full text Add to dashboard Cite

show abstract

“…15,16 Originally, PMAstimulated peripheral blood mononuclear cells (PBMCs) were reported to transiently upregulate AICL transcripts in a manner analogous to the AICL-relative CD69. 21 We previously reported pronounced surface expression of AICL glycoproteins by the human premonocytic cell line U937 stimulating NK cytotoxicity in an NKp80-dependent manner. 19 In addition, NKp80-AICL interaction was shown to promote an activating cross-talk between NK cells and monocytes in the presence of inflammatory cytokines.…”

Section: Introductionmentioning

confidence: 94%

Genetically coupled receptor–ligand pair NKp80-AICL enables autonomous control of human NK cell responses

Klimosch

Bartel

Wiemann

et al. 2013

Blood

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“…The CD69 or AICL receptors 26,27 are widely expressed in the hematopoietic lineage and their functions and ligands are not clearly defined. Recently, the lectin-type LLT1 receptor was reported to be broadly expressed in lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

The centromeric part of the human NK gene complex: linkage of LOX-1 and LY49L with the CD94/NKG2 region

et al. 2000

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The natural killer (NK) gene complex is a genomic region containing lectin-type receptor genes. We have established a contig of PAC and BAC clones comprising about 1 Mb of the centromeric part of the NK gene complex. This region extends from the LOX-1 gene, which encodes a receptor for oxidized LDL and was found within 100 kb telomeric of the STS marker D12S77, contains the CD94 and NKG2 NK receptor genes and reaches beyond D12S852 on the proximal side. In this part we have mapped the human LY49L gene, a homologue of the rodent Ly49 genes, which encode important MHC class I receptors for the regulation of NK cell activity in rodents. The LY49L gene is localized 100 to 200 kb centromeric of the NKG2 gene cluster and 300 to 400 kb telomeric of the STS marker D12S841. Genomic sequencing of the complete gene including promoter and intron sequences confirmed that the structure is similar to the mouse Ly49 genes. Screening of several cDNA libraries did not detect any transcripts of putative additional human LY49 genes. In addition, in the course of these studies several EST sequences were localized in the region, one immediately upstream of the LY49L gene. Genes and Immunity (2000) 1, 280-287.

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AICL: a new activation-induced antigen encoded by the human NK gene complex

Abstract: AICL: a new activation induced antigen encoded by the human NK gene complexHamann, J.; Montgomery, K.T.; Lau, S.; Kucherlapati, R.; van Lier, R.A.W.

Cited by 51 publications

References 23 publications

An Efficient and Robust Statistical Modeling Approach to Discover Differentially Expressed Genes Using Genomic Expression Profiles

An Efficient and Robust Statistical Modeling Approach to Discover Differentially Expressed Genes Using Genomic Expression Profiles

Genetically coupled receptor–ligand pair NKp80-AICL enables autonomous control of human NK cell responses

The centromeric part of the human NK gene complex: linkage of LOX-1 and LY49L with the CD94/NKG2 region

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