AI reveals a damage signalling hierarchy that coordinates different cell behaviours driving wound re-epithelialisation
Jake Turley,
Francesca Robertson,
Isaac V. Chenchiah
et al.
Abstract:One of the key tissue movements driving closure of a wound is re-epithelialisation. Earlier wound healing studies have described the dynamic cell behaviours that contribute to wound re-epithelialisation, including cell division, cell shape changes and cell migration, as well as the signals that might regulate these cell behaviours. Here, we use a series of deep learning tools to quantify the contributions of each of these cell behaviours from movies of repairing wounds in theDrosophilapupal wing epithelium. We… Show more
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