Ahmed glaucoma valve implantation with Ologen^®Collagen Matrix for the surgical treatment of feline glaucoma

Abstract

An Ahmed valve implantation with an Ologen Collagen Matrix (Ologen CM, Aeon Astron, Leiden, the Netherlands) was performed for the treatment of uncontrolled glaucoma in a cat. This cat was a 5-year-old castrated Russian Blue male with a 12-week history of conjunctival hyperemia and mydriasis of the left eye. During the ophthalmic examination, the intraocular pressure (IOP) oculus sinister (OS) was 52 mmHg, and a narrow iridocorneal angle (ICA) was detected by gonioscopy. Medical treatment with Cosopt (2% dorzolamide and 0.5% timolol) failed to decrease the IOP. The left eye still had vision, and an Ahmed valve implantation was performed. During the gonioimplantation, Ologen CM was used to inhibit scar formation around the valve. Following the operation, the IOP was stable at an approximate average of 15 mmHg during the 7-month follow-up period, and vision in the left eye was retained without medication. An adequate subconjunctival filtering bleb was formed after 140 days. This is the first case report in which an Ahmed valve gonioimplant with an Ologen CM has been used for the surgical treatment of glaucoma in a cat.

Efficacy of biodegradable collagen matrix (Ologen® CM) in augmenting the success rate of Ahmed glaucoma valve implantation in canine glaucoma

“…Jeong et al 21 reported that when the criterion for HP incidence was set to 3 months, the success rate was significantly lower 2 years after AGV implantation in the group in which HP occurred than in the group in which HP did not occur. Several recently human studies that assessed success rates after AGV implantation also defined HP as an IOP >21 mmHg within the first 3 months after surgery 8,11,22 . We believe that when HP is used to predict tissue reactions, it is meaningful to set a 3‐month criterion and that it is appropriate to consider that an IOP rise after 3 months is a surgical failure, not HP.…”

“…A previous study reported that AGV implants with ologen (Ologen ® Collagen Matrix, Aeon Astron) were applied to a cat with glaucoma 8 . Adequate IOP and vision were preserved in this cat for 5 years, without any systemic and topical medications 8 .…”

“…A previous study reported that AGV implants with ologen (Ologen ® Collagen Matrix, Aeon Astron) were applied to a cat with glaucoma 8 . Adequate IOP and vision were preserved in this cat for 5 years, without any systemic and topical medications 8 . The biodegradable collagen matrix is placed over the drainage device implant, and influences healing by causing fibroblasts and myofibroblasts to ingress into the pores and secrete connective tissue, thus forming a loose matrix 9 .…”

Kedilerde Glokomun Cerrahi Yaklaşımlarla Kontrol Altına Alınması: Az Tercih Edilen Ancak Faydalı Bazı Seçenekler

“…Different filtration procedures to increase aqueous humor drainage have been described for the surgical treatment of glaucoma. Transscleral iridencleisis applied together with cyclodialysis and posterior sclerotomy, trabeculectomy, glaucoma shunts and gonioimplants are used for this purpose [2,3,9,11,12] . For many years, trabeculectomy has been used and accepted as the gold standard among filtration procedures in human medicine.…”

Safety and efficacy of topically applied 0.5% and 1% pirfenidone in a canine model of subconjunctival fibrosis

“…Aqueous humor shunts represent an important technique in the surgical treatment of glaucoma [1][2][3][4][5][6][7][8] and correct glaucoma's underlying pathology of decreased outflow. The limitation of aqueous humor shunts lies in the formation of scar tissue around the implant footplate, which results in decreased flow through the shunt, and a return of elevated intraocular pressure.…”