AGT rs4762 is associated with diastolic blood pressure in Mexicans with diabetic nephropathy

Vázquez‐Moreno, Miguel; Locia‐Morales, Daniel; Peralta‐Romero, Jesús; Sharma, Tanmay; Meyre, David; Cruz, Miguel; Flores‐Alfaro, Eugenia; Valladares‐Salgado, Adán

doi:10.1016/j.jdiacomp.2020.107826

Cited by 7 publications

(6 citation statements)

References 32 publications

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“…These SNPs can be found in exons or introns and may increase or decrease susceptibility to diseases (López‐Cortés et al., 2017). After searching the NCBI database for information on the AGT gene rs4762, rs699 and rs1926723 variations, it was found that AGT gene is located at position 1q42–43 on chromosome 1 and has a length of 13 kb separated into five exons and four introns (Carlos‐Escalante et al., 2021; Vázquez‐Moreno et al., 2021). Specifically for the rs1926723 variation and using GRCh37 as the genome build, it was determined that it is located in the first intron and has two SNPs present: T > C/T > G at g.230840096.…”

Section: Discussionmentioning

confidence: 99%

Correlation of single nucleotide polymorphisms in the AGT gene with susceptibility to systemic lupus erythematosus in Northeast China

Wu,

Zhang,

Lin

et al. 2024

Int J Immunogenetics

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To investigate the correlation between susceptibility to systemic lupus erythematosus (SLE) and single nucleotide polymorphisms (SNPs) rs699, rs4762 and rs1926723 in the AGT gene in the population of Northeast China, while also introducing a new method for early detection of SLE. A total of 856 cases of SLE patients and healthy volunteers who attended the First Affiliated Hospital of Harbin Medical University from January 2020 to December 2022 were recruited. Clinical information and biood samples were collected from particpants in this study. SNaPshot sequencing technology was used to sequence the bases of the rs699, rs4762 and rs1926723 in the AGT gene. The genetic stability of SNPs was analysed by means of Hardy–Weinberg (HWE) genetic equilibrium. The study examined the correlation between genetically stable SNPs and susceptibility to SLE using logistic regression analysis.Rs699 did not adhere to the principles of the HWE genetic equilibrium (p < .01). Conversely, both rs4762 and rs1926723 conformed to the HWE genetic equilibrium (p > .05). However, no significant differences in genotypes and alleles frequencies of the rs4762 were observed between the two groups (p > .05). Furthermore, there was a significant difference in the distribution of AG, GG genotypes frequency and G allele frequency at the rs1926723 between the two groups (p < .001). Individuals with AG and GG genotypes and the G allele had a significantly lower frequency of SLE, indicating a potential genetic protective factor against susceptibility to the SLE.The SNPs rs1926723 may be linked to the susceptibility to SLE, and the AG, GG genotypes and the G allele may be important protective factors for the development of SLE in Northeast China.

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Section: Discussionmentioning

confidence: 99%

Correlation of single nucleotide polymorphisms in the AGT gene with susceptibility to systemic lupus erythematosus in Northeast China

Wu,

Zhang,

Lin

et al. 2024

Int J Immunogenetics

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“…Using the row data and the one-way ANOVA test, we compared the serum Se levels between the normal weight, overweight and obesity groups. We evaluated the normality distribution of quantitative variables with the Shapiro–Wilk test and the rank-based inverse normal transformation [ 35 ] was employed to normalize the variables that did not reach a normal distribution ( Appendix A ). With the row data, we evaluated trough Spearman correlation for the simple association between the cardiometabolic traits and serum Se levels.…”

Section: Methodsmentioning

confidence: 99%

Sex-Specific Association between Fasting Plasma Glucose and Serum Selenium Levels in Adults from Southern Mexico

et al. 2022

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Selenium (Se) is an essential trace element that by its antioxidant properties has been studied to elucidate its participation in the development of obesity and type 2 diabetes. We evaluated the association between cardiometabolic traits and serum Se levels in a sample of adults from southern Mexico. In 96 nondiabetic individuals, anthropometric data and clinical biochemistry measurements were analyzed. Serum total Se levels were measured with inductively coupled plasma mass spectrometry (ICP-MS). Serum Se level in the whole sample was 10.309 ± 3.031 μg mL−1 and no difference between the women and men was observed (p = 0.09). Additionally, fasting plasma glucose (FPG) was significantly associated with serum Se level (β = −0.07 ± 0.03, p = 0.02, analysis adjusted for age, sex and BMI). Furthermore, sex shows significant interaction with FPG on the serum Se levels (p = 0.01). A follow-up analysis revealed the particular association between FPG and Se levels in women (β = −0.10 ± 0.04, p = 0.01). In conclusion, our data evidenced a women-specific association between FPG and serum Se levels in a sample of adults from southern Mexico.

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“…Diabetic nephropathy was defined as urinary albumin creatinine ratio ≥ 30 mg/g in the absence of other primary causes of kidney damage [ 21 ]. Diabetic neuropathy was tested with a 128-Hz tuning fork for vibration sense and a 10-g monofilament test for light touch perception (on four sites per foot) [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

A prediction model for worsening diabetic retinopathy after panretinal photocoagulation

Lei

et al. 2022

Diabetol Metab Syndr

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Background As one of the severe complications of diabetes mellitus, diabetic retinopathy (DR) is the leading cause of blindness in the working age worldwide. Although panretinal photocoagulation (PRP) was standard treatment, PRP-treated DR still has a high risk of progression. Hence, this study aimed to assess the risk factors and establish a model for predicting worsening diabetic retinopathy (DR-worsening) within five years after PRP. Methods Patients who were diagnosed with severe non-proliferative diabetic retinopathy or proliferative diabetic retinopathy and treated with PRP were included, and those patients were randomly assigned to either a training or validation cohort. The multivariate logistic regression analysis was used to screen potential risk factors for DR-worsening in the training cohort. Then the model was established after including significant independent risk factors and further validated using discrimination and calibration. Results A total of 271 patients were included, and 56.46% of patients had an outcome of DR-worsening. In the training cohort (n = 135), age (odds ratio [OR] = 0.94, 95% confidence interval [CI] 0.90–0.98), baseline best corrected visual acuity (logMAR) (OR = 10.74, 95% CI 1.84–62.52), diabetic nephropathy (OR = 9.32, 95% CI 1.49–58.46), and hyperlipidemia (OR = 3.34, 95% CI 1.05–10.66) were screened out as the independent risk factors, which were incorporated into the predictive model. The area under the receiver operating characteristic curve and calibration slope in the training and validation cohort were 0.79, 0.96 (95% CI 0.60–1.31), and 0.79, 1.00 (95% CI 0.66–1.34), respectively. Two risk groups were developed depending on the best cut-off value of the predicted probability, and the actual probability was 34.90% and 82.79% in the low-risk and high-risk groups, respectively (P < 0.001). Conclusions This study developed and internally validated a new model to predict the probability of DR-worsening after PRP treatment within five years. The model can be used as a rapid risk assessment system for clinical prediction of DR-worsening and identify individuals at a high risk of DR-worsening at an early stage and prescribe additional treatment.

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AGT rs4762 is associated with diastolic blood pressure in Mexicans with diabetic nephropathy

Cited by 7 publications

References 32 publications

Correlation of single nucleotide polymorphisms in the AGT gene with susceptibility to systemic lupus erythematosus in Northeast China

Correlation of single nucleotide polymorphisms in the AGT gene with susceptibility to systemic lupus erythematosus in Northeast China

Sex-Specific Association between Fasting Plasma Glucose and Serum Selenium Levels in Adults from Southern Mexico

A prediction model for worsening diabetic retinopathy after panretinal photocoagulation

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