AGT May Serve as a Prognostic Biomarker and Correlated with Immune Infiltration in Gastric Cancer

Wu, Fengpeng; Zhang, Longguo; Wang, Li; Zhang, Dekui

doi:10.2147/ijgm.s351662

Cited by 5 publications

(5 citation statements)

References 44 publications

(50 reference statements)

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“…11B ). Most of these pathways belong to signaling cascades associated to regulate the inflammatory and immune responses (CD22 36 , MHC-I 37 , CD52 38 , CHEMERIN 39 , CD226 40 , NECTIN 41 , MHC-II 42 , SN, CD23 43 , CD80 44 , TNF 45 , CSF 46 , APRIL 47 , IL10 48 , PVR 49 , AGT 50 , IL16 51 , CEACAM 52 , CD200 53 , OCLN 54 , ACTIVIN 55 , ANNEXIN 56 , SELPLG 57 , CD86 44 , CXCL 58 , SEMA4 59 , PECAM1 60 , TGFb 61 , BST2 62 , SELL 63 , LAIR1 64 , ITGAL-ITGB2 65 , JAM 66 , CCL 67 , MIF 68 , VCAM 69 , ICAM 70 , COMPLEMENT 71 , PROS 72 and CD45 73 ) (Supplementary Fig. 11B ).…”

Section: Resultsmentioning

confidence: 99%

Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage

Ruz-Maldonado,

Gonzalez,

Zhang

et al. 2024

Nat Commun

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Midlobular hepatocytes are proposed to be the most plastic hepatic cell, providing a reservoir for hepatocyte proliferation during homeostasis and regeneration. However, other mechanisms beyond hyperplasia have been little explored and the contribution of other hepatocyte subpopulations to regeneration has been controversial. Thus, re-examining hepatocyte dynamics during regeneration is critical for cell therapy and treatment of liver diseases. Using a mouse model of hepatocyte- and non-hepatocyte- multicolor lineage tracing, we demonstrate that midlobular hepatocytes also undergo hypertrophy in response to chemical, physical, and viral insults. Our study shows that this subpopulation also combats liver impairment after infection with coronavirus. Furthermore, we demonstrate that pericentral hepatocytes also expand in number and size during the repair process and Galectin-9-CD44 pathway may be critical for driving these processes. Notably, we also identified that transdifferentiation and cell fusion during regeneration after severe injury contribute to recover hepatic function.

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Section: Resultsmentioning

confidence: 99%

Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage

Ruz-Maldonado,

Gonzalez,

Zhang

et al. 2024

Nat Commun

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“…The novel tuft cell ligands encoded by Frem1, Fras1 and Agt may have tumor suppressor functions, but have also been found to correlate with immune infiltration and metastasis [46][47][48][49], while Mif could suppress anti-tumor immunity of infiltrating immune cells [50] (Fig. 7B).…”

Section: Discussionmentioning

confidence: 99%

Appearance of tuft cells during prostate cancer progression

et al. 2023

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Tuft cells are chemosensory epithelial cells that increase in number following infection or injury to robustly activate the innate immune response to alleviate or promote disease. Recent studies of castration resistant prostate cancer and its subtype, neuroendocrine prostate cancer, revealed Pou2f3+ populations in mouse models. The transcription factor Pou2f3 is a master regulator of the tuft cell lineage. We show that tuft cells are upregulated early during prostate cancer development, and their numbers increase with progression. Cancer-associated tuft cells in the mouse prostate express DCLK1, COX1, COX2, while human tuft cells express COX1. Mouse and human tuft cells exhibit strong activation of signaling pathways including EGFR and SRC-family kinases. While DCLK1 is a mouse tuft cell marker, it is not present in human prostate tuft cells. Tuft cells that appear in mouse models of prostate cancer display genotype-specific tuft cell gene expression signatures. Using bioinformatic analysis tools and publicly available datasets, we characterized prostate tuft cells in aggressive disease and highlighted differences between tuft cell populations. Our findings indicate that tuft cells contribute to the prostate cancer microenvironment and may promote development of more advanced disease. Further research is needed to understand contributions of tuft cells to prostate cancer progression.

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“…In addition, there are three ways for IGFBP1 to participate in tumor immunity, one is by mediating Cell surface receptor signaling pathway, and the others are by mediating cytokine production pathway or Monocyte signaling pathway 39 . In addition, AGT has the potential to serve as a biomarker for GC prognosis and immune infiltration 40 .…”

Section: Discussionmentioning

confidence: 99%

Bacterial lipopolysaccharide related genes signature as potential biomarker for prognosis and immune treatment in gastric cancer

Yuan,

Zhang,

et al. 2023

Sci Rep

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The composition of microbial microenvironment is an important factor affecting the development of tumor diseases. However, due to the limitations of current technological levels, we are still unable to fully study and elucidate the depth and breadth of the impact of microorganisms on tumors, especially whether microorganisms have an impact on cancer. Therefore, the purpose of this study is to conduct in-depth research on the role and mechanism of prostate microbiome in gastric cancer (GC) based on the related genes of bacterial lipopolysaccharide (LPS) by using bioinformatics methods. Through comparison in the Toxin Genomics Database (CTD), we can find and screen out the bacterial LPS related genes. In the study, Venn plots and lasso analysis were used to obtain differentially expressed LPS related hub genes (LRHG). Afterwards, in order to establish a prognostic risk score model and column chart in LRHG features, we used univariate and multivariate Cox regression analysis for modeling and composition. In addition, we also conducted in-depth research on the clinical role of immunotherapy with TMB, MSI, KRAS mutants, and TIDE scores. We screened 9 LRHGs in the database. We constructed a prognostic risk score and column chart based on LRHG, indicating that low risk scores have a protective effect on patients. We particularly found that low risk scores are beneficial for immunotherapy through TIDE score evaluation. Based on LPS related hub genes, we established a LRHG signature, which can help predict immunotherapy and prognosis for GC patients. Bacterial lipopolysaccharide related genes can also be biomarkers to predict progression free survival in GC patients.

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AGT May Serve as a Prognostic Biomarker and Correlated with Immune Infiltration in Gastric Cancer

Cited by 5 publications

References 44 publications

Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage

Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage

Appearance of tuft cells during prostate cancer progression

Bacterial lipopolysaccharide related genes signature as potential biomarker for prognosis and immune treatment in gastric cancer

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