AgRP neurons trigger long-term potentiation and facilitate food seeking

Wang, Chunmei; Zhou, Wolong; He, Yang; Yang, Tsung Hsun; Xu, Pingwen; Yang, Yongjie; Cai, Xing; Wang, Julia; Liu, Hesong; Yu, Meng; Liang, Changhong; Yang, Tingting; Liu, Hailan; Fukuda, Makoto; Tong, Qingchun; Wu, Qi; Sun, Zheng; He, Yanlin; Xu, Yong

doi:10.1038/s41398-020-01161-1

Cited by 25 publications

(26 citation statements)

References 72 publications

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“…The AgRP neurons are sensitive to energy balance signals and powerfully drive food consumption, via GABA or NPY release (Krashes et al, 2013). Notably, the AgRP-PVT pathway was shown to be important for food seeking and learning about food location but not for consumption (Wang et al, 2021). Interestingly, that pathway engaged AgRP and NPY, rather than GABA signaling, consistent with the notion that different substrates underlie food seeking and consumption.…”

Section: Food Seeking Behaviors: Pvt Circuitries For Homeostatic and Cognitive Signalssupporting

confidence: 61%

“…In addition to cortical inputs, hypothalamic inputs to the PVT from the arcuate nucleus AgRP (NPY/GABA) neurons have been shown to drive food seeking behaviors (Livneh et al, 2017;Wang et al, 2021). The AgRP neurons are sensitive to energy balance signals and powerfully drive food consumption, via GABA or NPY release (Krashes et al, 2013).…”

Section: Food Seeking Behaviors: Pvt Circuitries For Homeostatic and Cognitive Signalsmentioning

confidence: 99%

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The Function of Paraventricular Thalamic Circuitry in Adaptive Control of Feeding Behavior

Petrovich

2021

Front. Behav. Neurosci.

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The paraventricular nucleus of the thalamus (PVT) is a complex area that is uniquely embedded across the core feeding, reward, arousal, and stress circuits. The PVT role in the control of feeding behavior is discussed here within a framework of adaptive behavioral guidance based on the body’s energy state and competing drives. The survival of an organism depends on bodily energy resources and promotion of feeding over other behaviors is adaptive except when in danger or sated. The PVT is structurally set up to respond to homeostatic and hedonic needs to feed, and to integrate those signals with physiological and environmental stress, as well as anticipatory needs and other cognitive inputs. It can regulate both food foraging (seeking) and consumption and may balance their expression. The PVT is proposed to accomplish these functions through a network of connections with the brainstem, hypothalamic, striatal, and cortical areas. The connectivity of the PVT further indicates that it could broadcast the information about energy use/gain and behavioral choice to impact cognitive processes—learning, memory, and decision-making—through connections with the medial and lateral prefrontal cortical areas, the hippocampal formation, and the amygdala. The PVT is structurally complex and recent evidence for specific PVT pathways in different aspects of feeding behavior will be discussed.

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Section: Food Seeking Behaviors: Pvt Circuitries For Homeostatic and Cognitive Signalssupporting

confidence: 61%

Section: Food Seeking Behaviors: Pvt Circuitries For Homeostatic and Cognitive Signalsmentioning

confidence: 99%

The Function of Paraventricular Thalamic Circuitry in Adaptive Control of Feeding Behavior

Petrovich

2021

Front. Behav. Neurosci.

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“…In addition to the presence of certain genes affecting responses to adversity, experiences of adversity may influence genetic expression through epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNA (for reviews, see [ 103 , 104 ]). In fact, many candidate gene and epigenome-wide association studies have documented correlations between early adversity and alterations in the epigenome [ 105 – 108 ]. In turn, alterations that change the expression of genes in the brain affect various molecular processes, including mechanisms of neurodevelopment, that affect risk for depression (for a review, see [ 104 ]).…”

Section: Overview Of Models Linking Adversity To Mental Disordersmentioning

confidence: 99%

Mechanisms of neuroplasticity linking early adversity to depression: developmental considerations

King

2021

Transl Psychiatry

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Early exposure to psychosocial adversity is among the most potent predictors of depression. Because depression commonly emerges prior to adulthood, we must consider the fundamental principles of developmental neuroscience when examining how experiences of childhood adversity, including abuse and neglect, can lead to depression. Considering that both the environment and the brain are highly dynamic across the period spanning gestation through adolescence, the purpose of this review is to discuss and integrate stress-based models of depression that center developmental processes. We offer a general framework for understanding how psychosocial adversity in early life disrupts or calibrates the biobehavioral systems implicated in depression. Specifically, we propose that the sources and nature of the environmental input shaping the brain, and the mechanisms of neuroplasticity involved, change across development. We contend that the effects of adversity largely depend on the developmental stage of the organism. First, we summarize leading neurobiological models that focus on the effects of adversity on risk for mental disorders, including depression. In particular, we highlight models of allostatic load, acceleration maturation, dimensions of adversity, and sensitive or critical periods. Second, we expound on and review evidence for the formulation that distinct mechanisms of neuroplasticity are implicated depending on the timing of adverse experiences, and that inherent within certain windows of development are constraints on the sources and nature of these experiences. Finally, we consider other important facets of adverse experiences (e.g., environmental unpredictability, perceptions of one’s experiences) before discussing promising research directions for the future of the field.

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“…90 LH orexin neurons are mainly glutamatergic, but some may be GABAergic. 91 Moreover, activation of ARC AGRP neurons was shown to inhibit and induce long-term depression in postsynaptic neurons of several other projection regions; 92 while the LH was not studied, it is likely that the same phenomenon occurs in both LH VGAT and LH VGLUT2 neurons. Deciphering the significance of this on feeding drives will likely prove an interesting line of future research.…”

Section: Articlementioning

confidence: 99%