AgRP neurons coordinate the mitigation of activity-based anorexia

Hickey, Ames K Sutton; Duane, Sean C.; Mickelsen, Laura E; Karolczak, Eva O; Shamma, Ahmed M.; Skillings, Anna; Li, Chia; Krashes, Michael J.

doi:10.1038/s41380-022-01932-w

Cited by 11 publications

(6 citation statements)

References 73 publications

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“…Although functional alterations of brain regions associated with AN have been observed in human neuroimaging studies, 15 – 17 and neurons regulating some of the ABA phenotypes have been identified in animals studies, 7 , 9 , 17 , 29 , 33 , 39 – 43 details of neural mechanisms that might cause AN are still being uncovered. 22 , 23 , 44 …”

Section: Discussionmentioning

confidence: 99%

Development of activity-based anorexia requires PKC-δ neurons in two central extended amygdala nuclei

Schnapp,

Kim,

Wang

et al. 2024

Cell Reports

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Section: Discussionmentioning

confidence: 99%

Development of activity-based anorexia requires PKC-δ neurons in two central extended amygdala nuclei

Schnapp,

Kim,

Wang

et al. 2024

Cell Reports

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“…These behaviors mimic those observed in anorexia nervosa patients. A recent study 77 highlighted AgRP neurons as a potential neural target for addressing maladaptive behaviors in anorexia nervosa. Activation of AgRP neurons can mitigate the development and progression of ABA by reprioritizing food intake over stress-induced hyperactivity during periods of food availability.…”

Section: Predisposition To Stress May Lead To Seeking Of a Starvation...mentioning

confidence: 99%

Chronic stress triggers seeking of a starvation-like state in anxiety-prone female mice

Kucukdereli,

Amsalem,

Pottala

et al. 2023

Preprint

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Elevated anxiety often precedes anorexia nervosa and persists after weight restoration. Patients with anorexia nervosa often describe hunger as pleasant, potentially because food restriction can be anxiolytic. Here, we tested whether chronic stress can cause animals to prefer a starvation-like state. We developed a virtual reality place preference paradigm in which head-fixed mice can voluntarily seek a starvation-like state induced by optogenetic stimulation of hypothalamic agouti-related peptide (AgRP) neurons. Prior to stress induction, male but not female mice showed mild aversion to AgRP stimulation. Strikingly, following chronic stress, a subset of females developed a strong preference for AgRP stimulation that was predicted by high baseline anxiety. Such stress-induced changes in preference were reflected in changes in facial expressions during AgRP stimulation. Our study suggests that stress may cause females predisposed to anxiety to seek a starvation state, and provides a powerful experimental framework for investigating the underlying neural mechanisms.

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“…al. reported that agouti-related peptide (AgRP) releasing neuron activity in ABA animals showed a poor inhibitory response to food, independent of changes in basal activity [24]. AN may also be conceptualized as a form of genetic resistance to hunger, thus allowing for a particularly strong personal commitment to perpetuate food restriction [25].…”

Section: Anorexia Nervosa (An)mentioning

confidence: 99%

Current Discoveries and Future Implications of Eating Disorders

Feng

Harms

Chen

et al. 2023

IJERPH

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Eating disorders (EDs) are characterized by severe disturbances in eating behaviors and can sometimes be fatal. Eating disorders are also associated with distressing thoughts and emotions. They can be severe conditions affecting physical, psychological, and social functions. Preoccupation with food, body weight, and shape may also play an important role in the regulation of eating disorders. Common eating disorders have three major types: anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). In some cases, EDs can have serious consequences for an individual’s physical and mental health. These disorders often develop during adolescence or early adulthood and affect both males and females, although they are more commonly diagnosed in young adult females. Treatment for EDs typically involves a combination of therapy, nutrition counseling, and medical care. In this narrative review, the authors summarized what is known of EDs and discussed the future directions that may be worth exploring in this emerging area.

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AgRP neurons coordinate the mitigation of activity-based anorexia

Cited by 11 publications

References 73 publications

Development of activity-based anorexia requires PKC-δ neurons in two central extended amygdala nuclei

Development of activity-based anorexia requires PKC-δ neurons in two central extended amygdala nuclei

Chronic stress triggers seeking of a starvation-like state in anxiety-prone female mice

Current Discoveries and Future Implications of Eating Disorders

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