Agrochemicals disrupt multiple endocrine axes in amphibians

Trudeau, Vance L.; Thomson, Paisley; Zhang, Wo Su; Reynaud, Stéphane; Navarro‐Martín, Laia; Langlois, Valérie S.

doi:10.1016/j.mce.2020.110861

Cited by 50 publications

(24 citation statements)

References 228 publications

(248 reference statements)

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“…Despite experiencing similar pressures to reptiles and greater sensitivity to perturbations (Stuart et al, 2004), amphibians are one of the least protected taxa under CITES regulation with only 2.4% of all known species listed (second only to fish at 0.46%: http://www.fishbase.org/home.htm), despite showing faster population declines than any other vertebrate group (Hoffmann et al, 2010). Often dubbed canaries in the coal-mine amphibians are sensitive to a myriad of anthropogenic stressors: pollution (Blaustein et al, 2003), habitat loss (Stuart et al, 2004), atmospheric changes (Blaustein et al, 2003), introduced pathogens (Lips, 2016), invasive species (Bellard et al, 2016), wildlife collection (Phimmachak et al, 2012); and agricultural chemicals (Trudeau et al, 2020); such stressors are exacerbated by amphibians' frequently small distributions and naturally fluctuating populations (Nori et al, 2018;Luo et al, 2015;Hu et al, 2012). Amphibian trade is directly tied to the last three stressors.…”

Section: Introductionmentioning

confidence: 99%

Gaps in global wildlife trade monitoring leave amphibians vulnerable

Hughes

Marshall

Strine

2021

eLife

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As the biodiversity crisis continues, we must redouble efforts to understand and curb pressures pushing species closer to extinction. One major driver is the unsustainable trade of wildlife. Trade in internationally regulated species gains the most research attention, but this only accounts for a minority of traded species and we risk failing to appreciate the scale and impacts of unregulated legal trade. Despite being legal, trade puts pressure on wild species via: direct collection, introduced pathogens, and invasive species. Smaller species-rich vertebrates, such reptiles, fish, and amphibians, may be particularly vulnerable to trading because of gaps in regulations, small distributions, and demand of novel species. Here we combine data from five sources: online web searches in six languages, CITES trade database, LEMIS trade inventory, IUCN assessments, and a recent literature review, to characterise the global trade in amphibians, and also map use by purpose including meat, pets, medicinal and for research. We show that 1,215 species are being traded (17% of amphibian species), almost three times previous recorded numbers, 345 are threatened, and 100 data deficient or unassessed. Traded species origin hotspots include South American, China, and Central Africa; sources indicate 42% of amphibians are taken from the wild. Newly described species can be rapidly traded (mean time lag of 6.5 years), including threatened and unassessed species. The scale and limited regulation of the amphibian trade, paired with the triptych of connected pressures (collection, pathogens, invasive species), warrants a re-examination of the wildlife trade status-quo, application of the precautionary principle in regards to wildlife trade, and a renewed push to achieve global biodiversity goals.

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Section: Introductionmentioning

confidence: 99%

Gaps in global wildlife trade monitoring leave amphibians vulnerable

Hughes

Marshall

Strine

2021

eLife

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“…EDC impact wild anurans and contribute to population declines. Some pesticides and biocides may interfere with TH signaling during nervous system development (Leemans et al, 2019;Trudeau et al, 2020) or metamorphosis timing (Orton and Tyler, 2015). Last but not least, exposition of Xenopus tadpoles to the benzo[a]pyrene leads to delayed metamorphosis and sexual maturity with transgenerational disruption of metabolism and population decline (Usal et al, 2021).…”

Section: Thyroid Function Disruptionmentioning

confidence: 99%

Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

2021

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Post-embryonic acute developmental processes mainly allow the transition from one life stage in a specific ecological niche to the next life stage in a different ecological niche. Metamorphosis, an emblematic type of these post-embryonic developmental processes, has occurred repeatedly and independently in various phylogenetic groups throughout metazoan evolution, such as in cnidarian, insects, molluscs, tunicates, or vertebrates. This review will focus on metamorphoses and developmental transitions in vertebrates, including typical larval metamorphosis in anuran amphibians, larval and secondary metamorphoses in teleost fishes, egg hatching in sauropsids and birth in mammals. Two neuroendocrine axes, the hypothalamic-pituitary-thyroid and the hypothalamic-pituitary-adrenal/interrenal axes, are central players in the regulation of these life transitions. The review will address the molecular and functional evolution of these axes and their interactions. Mechanisms of integration of internal and environmental cues, and activation of these neuroendocrine axes represent key questions in an “eco-evo-devo” perspective of metamorphosis. The roles played by developmental transitions in the innovation, adaptation, and plasticity of life cycles throughout vertebrates will be discussed. In the current context of global climate change and habitat destruction, the review will also address the impact of environmental factors, such as global warming and endocrine disruptors on hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal/interrenal axes, and regulation of developmental transitions.

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“…Water contaminants that interfere in endocrine systems (endocrine disruptors [ED]) have adverse effects on amphibian development (Kloas et al, 2009; Trudeau et al, 2020). Various EDs simultaneously affect thyroids and gonads, which lead to complex developmental anomalies (Phuge, 2020; Regnault et al, 2018; Solomon et al, 2008; Tamschick, Rozenblut‐Kościsty, Ogielska, Lehmann, Lymberakis, Hoffmann, Lutz, Schneider, et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Effect of ethylenethiourea on metamorphosis and ovary development: A comparative study of three larval frogs

2021

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Amphibian endocrine systems interact with each other during normal development.Interference with one of the endocrine systems may influence others. We studied the effect of a thyroid inhibitor (ethylenethiourea [ETU]) on metamorphosis and ovary development of three species, Sphaerotheca pashchima, Indosylvirana caesari, and Euphlyctis cyanophlyctis with different larval durations. We treated the tadpoles of these species with 50, 100, and 200 mg/L concentrations of ETU and studied their larval duration, size at metamorphosis, and ovary development. The results revealed that ETU affects metamorphosis, depending on the species and concentration. ETU delayed metamorphosis of E. cyanophlyctis tadpoles and did not affect metamorphosis in S. pashchima tadpoles. Lower concentrations of ETU stimulated metamorphosis in I. caesari tadpoles while high concentration delayed metamorphosis. In the tadpoles (E. cyanophlyctis) treated with higher concentrations of ETU, ovary development was advanced with an increased size of the diplotene oocytes. Oocyte size was smaller in the tadpoles (of I. caesari) treated with lower concentrations of ETU. These results demonstrated that the tadpoles of these species show different responses to the thyroid inhibitor, possibly due to the differences in the larval duration and sensitivity. Inhibition or acceleration of metamorphosis did not interfere in the ovary development of E. cyanophlyctis and I. caesari. These results will be useful in understanding the impact of endocrine disruptors on the interaction between thyroid and sex steroid hormones.

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Agrochemicals disrupt multiple endocrine axes in amphibians

Cited by 50 publications

References 228 publications

Gaps in global wildlife trade monitoring leave amphibians vulnerable

Gaps in global wildlife trade monitoring leave amphibians vulnerable

Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

Effect of ethylenethiourea on metamorphosis and ovary development: A comparative study of three larval frogs

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