Agrochemical properties evaluation of some imines alkaloids of matrine/oxymatrine

Lv, Min; Ma, Qianjun; Zhang, Shaoyong; Xu, Hui

doi:10.1016/j.bmcl.2021.128246

Cited by 12 publications

(7 citation statements)

References 15 publications

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“…Its intensity inside the body is comparable with that of chloramphenicol, and the alcohol extract has an antitrichomoniasis effect outside the body. [ 4 ] Furthermore, matrine and oxymatrine have inhibitory effects on immune function in mice. Intramuscular injection of oxymatrine can inhibit passive or active allergic skin reactions in rabbits and rats.…”

Section: Discussionmentioning

confidence: 99%

Eczema compound patents’ herbal combination rules research based on complex system entropy clustering: A review

Yang

Pei

2022

Medicine

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The aim of this study is to investigate the herbal compound patents' combination rules of eczema. Eczema herbal compound patents (oral drugs) from the past 29 years were collected, and a database was created. Complex system entropy clustering was used to analyze the prescription rule for eczema herbal compound patents. In total, 1039 eczema herbal compound patents, including 398 Chinese herbs, were identified. Complex system entropy clustering acquired high-frequency herbs, herbal couples, and core associations. Eczema herbal compound patents are known for clearing dampness and heat, dispelling poison, evacuating wind, and invigorating and cooling blood. By using complex system entropy clustering, herbal correlation of eczema herbal compound patents can be effectively analyzed.

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Section: Discussionmentioning

confidence: 99%

Eczema compound patents’ herbal combination rules research based on complex system entropy clustering: A review

Yang

Pei

2022

Medicine

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“…Matrine was one of the promising botanical pesticides registered in China due to its good insecticidal, antibacterial, and other agricultural activities [17][18][19][20]. Oxymatrine showed a wide range of biological properties, such as pesticidal [21,22], antiviral [23], anti-inflammatory [24], and anti-tumor effects [25]. The monoterpene 1,8-cineole (CN, Figure 1, eucalyptol), an essential oil isolated from the eucalyptus leaves, exhibited a variety of interesting activities, such as antimicrobial [26,27], anti-inflammatory [28], and insecticidal properties [29,30].…”

Section: Introductionmentioning

confidence: 99%

Exploration of Synergistic Pesticidal Activities, Control Effects and Toxicology Study of a Monoterpene Essential Oil with Two Natural Alkaloids

Fang

et al. 2023

Toxins

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With the increasing development of pest resistances, it is not easy to achieve satisfactory control effects by using only one agrochemical. Additionally, although the alkaloid matrine (MT) isolated from Sophora flavescens is now utilized as a botanical pesticide in China, in fact, its pesticidal activities are much lower in magnitude than those of commercially agrochemicals. To improve its pesticidal activities, here, the joint pesticidal effects of MT with another alkaloid oxymatrine (OMT) (isolated from S. flavescens) and the monoterpene essential oil 1,8-cineole (CN) (isolated from the eucalyptus leaves) were investigated in the laboratory and greenhouse conditions. Moreover, their toxicological properties were also studied. Against Plutella xylostella, when the mass ratio of MT and OMT was 8/2, good larvicidal activity was obtained; against Tetranychus urticae, when the mass ratio of MT and OMT was 3/7, good acaricidal activity was obtained. Especially when MT and OMT were combined with CN, the significant synergistic effects were observed: against P. xylostella, the co-toxicity coefficient (CTC) of MT/OMT (8/2)/CN was 213; against T. urticae, the CTC of MT/OMT (3/7)/CN was 252. Moreover, the activity changes over time of two detoxification enzymes, carboxylesterase (CarE) and glutathione S-transferase (GST) of P. xylostella treated with MT/OMT (8/2)/CN, were observed. In addition, by scanning electron microscope (SEM), the toxicological study suggested that the acaricidal activity of MT/OMT (3/7)/CN may be related to the damage of the cuticle layer crest of T. urticae.

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“…Moreover, many matrine derivatives are also found to have good agricultural activities [ 8 , 9 ], which is our concern. Xu group synthesized a large amount of matrine derivatives and found some of them had good insecticidal/acaricidal activity against Mythimna separata Walker, Plutella xylostella Linnaeus, Aphis citricola Van der Goot and/or Tetranychus cinnabarinus ; these molecules included ether derivatives [ 10 ], oximinoether derivatives [ 11 ], imine derivatives [ 12 ], spiro-1,2,4-oxadiazoline-fused matrine derivatives [ 13 ], and pyrazolomatrine derivatives [ 14 ], etc., that retain the tetracyclic structure, as well as the acid/alcohol/ester derivatives [ 15 , 16 ] and amide derivatives [ 17 , 18 ] with an opened D-ring. Jiang and Qin jointly reported the synthesis and insecticidal activity evaluation of two series of tetracyclic matrine derivatives with halopyrazole motif [ 19 ] or cyclohexylamine group [ 20 ] both at the C-13 position.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Evaluation of 11-Butyl Matrine Derivatives as Potential Anti-Virus Agents

Wang

Song

et al. 2022

Molecules

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Matrine derivatives were reported to have various biological activities, especially the ester, amide or sulfonamide derivatives of matrine deriving from the hydroxyl or carboxyl group at the end of the branch chain after the D ring of matrine is opened. In this work, to investigate whether moving away all functional groups from the C-11 branch chain could have an impact on the bioactivities, such as anti-tobacco mosaic virus (TMV), insecticidal and fungicidal activities, a variety of N-substituted-11-butyl matrine derivatives were synthesized. The obtained bioassay result showed that most N-substituted-11-butyl matrine derivatives had obviously enhanced anti-TMV activity compared with matrine, especially many compounds had good inhibitory activity close to that of commercialized virucide Ningnanmycin (inhibition rate 55.4, 57.8 ± 1.4, 55.3 ± 0.5 and 60.3 ± 1.2% at 500 μg/mL; 26.1, 29.7 ± 0.2, 24.2 ± 1.0 and 27.0 ± 0.3% at 100 μg/mL, for the in vitro activity, in vivo inactivation, curative and protection activities, respectively). Notably, N-benzoyl (7), N-benzyl (16), and N-cyclohexylmethyl-11-butyl (19) matrine derivatives had higher anti-TMV activity than Ningnanmycin at both 500 and 100 μg/mL for the four test modes, showing high potential as anti-TMV agent. Furthermore, some compounds also showed good fungicidal activity or insecticidal activity.

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Agrochemical properties evaluation of some imines alkaloids of matrine/oxymatrine

Cited by 12 publications

References 15 publications

Eczema compound patents’ herbal combination rules research based on complex system entropy clustering: A review

Eczema compound patents’ herbal combination rules research based on complex system entropy clustering: A review

Exploration of Synergistic Pesticidal Activities, Control Effects and Toxicology Study of a Monoterpene Essential Oil with Two Natural Alkaloids

Synthesis and Evaluation of 11-Butyl Matrine Derivatives as Potential Anti-Virus Agents

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