Agrimonia eupatoria L.: An integrative perspective on ethnomedicinal use, phenolic composition and pharmacological activity

Malheiros, Jéssica; Simões, Daniela M.; Figueirinha, Artur; Cotrim, Maria Dulce; Fonseca, Diogo A.

doi:10.1016/j.jep.2022.115498

Cited by 14 publications

(8 citation statements)

References 48 publications

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“…It has been used for the treatment of digestive tract diseases against gall bladder stones, colic, and urinary disorders and for mucus membrane and skin ulcers. Moreover, A. eupatoria is used for the treatment of metabolic disorders such as diabetes, as well as in the protection of the cardiovascular and respiratory system [1][2][3]. A. eupatoria is a source of various phytochemicals which may be responsible for its beneficial effects.…”

Section: Introductionmentioning

confidence: 99%

Efficiency of Natural Deep Eutectic Solvents to Extract Phenolic Compounds from Agrimonia eupatoria: Experimental Study and In Silico Modelling

Lazović¹,

Cvijetić

Jankov³

et al. 2022

Plants

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To replace common organic solvents that present inherent toxicity and have high volatility and to improve the extraction efficiency, a range of natural deep eutectic solvents (NADESs) were evaluated for the extraction of phenolic compounds from Agrimonia eupatoria. Screening of NADES efficiency was carried out based on the total phenolic and flavonoid content and radical-scavenging activity, determined by spectrophotometry, as well as phenolic compounds quantified, obtained using ultra-high-performance liquid chromatography with a diode array detector and a triple-quadrupole mass spectrometer. Increased extraction efficiency when compared with organic solvent was achieved using NADES mixtures choline chloride (ChCl):urea 1:2 and choline chloride:glycerol 1:1. Flavonol glycosides were the most abundant compounds in all extracts. The COSMO-RS model provided insights into the most important intermolecular interactions that drive the extraction process. Moreover, it could explain the extraction efficiency of flavonol glycosides using ChCl:glycerol NADES. The current article offers experimental evidence and mechanistic insights for the selection of optimal NADES to extract bioactive components from Agrimonia eupatoria.

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Section: Introductionmentioning

confidence: 99%

Efficiency of Natural Deep Eutectic Solvents to Extract Phenolic Compounds from Agrimonia eupatoria: Experimental Study and In Silico Modelling

Lazović¹,

Cvijetić

Jankov³

et al. 2022

Plants

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“…One of the most famous middle-European traditional medicinal plants is Agrimonia eupatoria L. The aerial part of agrimony is particularly rich in tannins (up to 11%), such as catechin, procyanidin B3, agrimoniin, and other phenolics (astragalin, cynaroside, hyperoside, isoquercitrin, isovitexin, and rutin). Thanks to its astringent, antimicrobial, anti-inflammatory, and wound-healing properties, this herbal remedy is recommended for the symptomatic relief of mild inflammation of the mouth and throat [20,77,78]. According to Ham and Kim (2018), four extracts of an agrimony herb (methanol, water, 50% ethanol, and 95% ethanol) inhibited the S. mutans biofilm formation in a dose-dependent manner [79].…”

Section: Tannins In Oral Healthmentioning

confidence: 99%

Therapeutic Potential of Flavonoids and Tannins in Management of Oral Infectious Diseases—A Review

et al. 2022

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Medicinal plants are rich sources of valuable molecules with various profitable biological effects, including antimicrobial activity. The advantages of herbal products are their effectiveness, relative safety based on research or extended traditional use, and accessibility without prescription. Extensive and irrational usage of antibiotics since their discovery in 1928 has led to the increasing expiration of their effectiveness due to antibacterial resistance. Now, medical research is facing a big and challenging mission to find effective and safe antimicrobial therapies to replace inactive drugs. Over the years, one of the research fields that remained the most available is the area of natural products: medicinal plants and their metabolites, which could serve as active substances to fight against microbes or be considered as models in drug design. This review presents selected flavonoids (such as apigenin, quercetin, kaempferol, kurarinone, and morin) and tannins (including oligomeric proanthocyanidins, gallotannins, ellagitannins, catechins, and epigallocatechin gallate), but also medicinal plants rich in these compounds as potential therapeutic agents in oral infectious diseases based on traditional usages such as Agrimonia eupatoria L., Hamamelis virginiana L., Matricaria chamomilla L., Vaccinium myrtillus L., Quercus robur L., Rosa gallica L., Rubus idaeus L., or Potentilla erecta (L.). Some of the presented compounds and extracts are already successfully used to maintain oral health, as the main or additive ingredient of toothpastes or mouthwashes. Others are promising for further research or future applications.

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“…Agrimonia eupatoria L. (also called church steeples, stickwort, common agrimony, and liverwort) is a perennial herb that has been used in folk medicine for its beneficial effects since the time of Ancient Greece [ 12 ]. It has been used for gastrointestinal disorders, diarrhea, cholecystitis, pneumonia, hepatopathy, pyelonephritis, cystitis, bleeding disorders, skin defects, and oral mucosal inflammatory diseases [ 13 , 14 ]. The results of published studies have confirmed its anti-inflammatory, astringent, diuretic, antimicrobial, antiviral, antioxidant, neuroprotective, and hepatoprotective effects, as well as many others [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

In Situ Gel with Silver Nanoparticles Prepared Using Agrimonia eupatoria L. Shows Antibacterial Activity

Balážová

Wolaschka

Rohaľová

et al. 2023

Life

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Silver nanoparticles (Ag NPs) with antibacterial activity can be prepared in different ways. In our case, we used ecological green synthesis with Agrimonia eupatoria L. The plant extract was used with Ag NPs for the first time to prepare termosensitive in situ gels (ISGs). Such gels are used to heal human or animal skin and mucous membranes, as they can change from a liquid to solid state after application. Ag NPs were characterized with various techniques (FTIR, TEM, size distribution, zeta potential) and their antibacterial activity was tested against Staphylococcus aureus and Escherichia coli. In accordance with the TEM data, we prepared monodispersed spherical Ag NPs with an average size of about 20 nm. Organic active compounds from Agrimonia eupatoria L. were found on their surfaces using FTIR spectroscopy. Surprisingly, only the in situ gel with Ag NPs showed antibacterial activity against Escherichia coli, while Ag NPs alone did not. Ag NPs prepared via green synthesis using plants with medicinal properties and incorporated into ISGs have great potential for wound healing due to the antibacterial activity of Ag NPs and the dermatological activity of organic substances from plants.

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Agrimonia eupatoria L.: An integrative perspective on ethnomedicinal use, phenolic composition and pharmacological activity

Cited by 14 publications

References 48 publications

Efficiency of Natural Deep Eutectic Solvents to Extract Phenolic Compounds from Agrimonia eupatoria: Experimental Study and In Silico Modelling

Efficiency of Natural Deep Eutectic Solvents to Extract Phenolic Compounds from Agrimonia eupatoria: Experimental Study and In Silico Modelling

Therapeutic Potential of Flavonoids and Tannins in Management of Oral Infectious Diseases—A Review

In Situ Gel with Silver Nanoparticles Prepared Using Agrimonia eupatoria L. Shows Antibacterial Activity

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