Resistance to antimicrobial compounds is one of the major threats to human and animal health in the 21st century. A recent report by the Centers for Disease Control and Prevention shows that over 2.8 million antibioticresistance infections are detected in the United States each year, with more than 35,000 people dying due to these infections (Kadri, 2020). Estimates suggest that by 2050 death from infections with antibiotic-resistant pathogens will eclipse those of cancer, and the total societal and financial costs of failing to address the crisis will be more than US$100 trillion (O'Neill, 2016).How did this crisis come about? The answer lies in both microbial ecology and in the potential for rapid evolution in bacteria. Antimicrobial drug resistance is a natural and ancient phenomenon, with natural environments containing hundreds of thousands of genes that could be co-opted to confer resistance (D'Costa et al., 2006). Human use and misuse of antimicrobial compounds have efficiently selected for antimicrobial-resistant commensals and pathogens, such that resistance is now common in human-dominated environments (Zhu et al., 2017a). Understanding interactions between the microbiome of natural environments and the microbiome of humans and agricultural animals will be critical for managing the crisis and even more so for devising solutions. The transdisciplinary 'One Health' concept describes the process of