Agricultural exposures to carbamate herbicides and fungicides and central nervous system tumour incidence in the cohort AGRICAN

Piel, Clément; Pouchieu, Camille; Carles, Camille; Béziat, Béatrix; Boulanger, Mathilde; Bureau, Mathilde; Busson, A; Gruber, A.; Lécluse, Yannick; Migault, Lucile; Renier, M.; Rondeau, Virginie; Schwall, Xavier; Tual, Séverine; Lebailly, Pierre; Baldi, Isabelle; Arveux, Patrick; Bara, Simona; Bouvier, Anne; Busquet, T.; Colonna, Marc; Coureau, Gaëlle; Delanoe, Marc; Grosclaude, Pascale; Guizard, Anne‐Valérie; Herbrecht, P.; Laplante, Jean‐Jacques; Lapôtre-Ledoux, Bénédicte; Launoy, Guy; Lenoir, Didier; Marrer, Émilie; Marcotullio, Elisabeth; Maynadié, Marc; Molinié, F.; Monnereau, Alain; Paumier, A.; Pouzet, Philippe; Thibaudier, J.M.; Troussard, Xavier; Velten, Michel; Wavelet, E.; Woronoff, Anne‐Sophie

doi:10.1016/j.envint.2019.05.070

Cited by 57 publications

(28 citation statements)

References 32 publications

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“…Experimental data with respect to this topic remain thus limited. It is notably the case for carbamate pesticides, extensively used for agricultural and non-agricultural purposes, and presumed to exert various deleterious effects towards human health, including endocrine disruption and carcinogenicity (Dhouib et al, 2016;Miranda-Contreras et al, 2013;Patel and Sangeeta, 2019;Piel et al, 2019). Indeed, only few data have been reported with respect to putative interactions of carbamates with transporters; they demonstrated a lack of inhibitory effects of some carbamates towards activity of the human ABC efflux pump P-glycoprotein (P-gp/ABCB1) (Bain and LeBlanc, 1996) and an inhibition of the rabbit ABC transporter breast cancer resistance protein (BCRP/ABCG2) by propamocarb (Halwachs et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Differential interactions of carbamate pesticides with drug transporters

et al. 2020

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1. Pesticides are now recognised to interact with drug transporters, but only few data are available on this issue for carbamate pesticides, a widely-used class of agrochemicals, to which humans are highly exposed. The present study was therefore designed to determine whether four representative carbamate pesticides, i.e., the insecticides aminocarb and carbofuran, the herbicide chlorpropham and the fungicide propamocarb, may impair activities of main drug transporters implicated in pharmacokinetics. 2. The interactions of carbamates with solute carrier and ATP-binding cassette transporters were investigated using cultured transporter-overexpressing cells, reference substrates and spectrofluorimetry-, liquid chomatography/tandem mass spectrometry-or radioactivity-based methods. 3. Aminocarb and carbofuran exerted no or minimal effects on transporter activities, whereas chlorpropham inhibited BCRP and OAT3 activities and propamocarb decreased those of OCT1 and OCT2, but cis-stimulated that of MATE2-K. Such alterations of transporters however required chlorpropham/propamocarb concentrations in the 5-50 µM range, likely not relevant to environmental exposure. Trans-stimulation assays and propamocarb accumulation experiments additionally suggested that propamocarb is not a substrate for OCT1, OCT2 and MATE2-K. 4. These data indicate that some carbamate pesticides can interact in vitro with some drug transporters, but only when used at concentrations higher than those expected to occur in environmentally-exposed humans.

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Section: Introductionmentioning

confidence: 99%

Differential interactions of carbamate pesticides with drug transporters

et al. 2020

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“…In the French Agrican cohort, elevated risks were observed in farmers exposed to speci c crops (peas, beets, potatoes) and risk doubled in those who applied pesticides (Piel et al 2017). Analysis focused on carbamate insecticides, fungicides and herbicides pointed to some speci c active ingredients being associated with a high increase in the risk (Piel et al 2019a(Piel et al , 2019b.…”

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confidence: 99%

Occupational exposure to pesticides and central nervous system tumors: results from the CERENAT case–control study

Baldi

Graaf

Bouvier

et al. 2021

Cancer Causes Control

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Background:The etiology of the central nervous system (CNS) tumors remains largely unknown. The role of pesticide exposure has been suggested by several epidemiological studies, but with no de nitive conclusion. Objective: To analyze associations between occupational pesticide exposure and primary CNS tumors in adults in the CERENAT study. Methods: CERENAT is a multicenter case-control study conducted in France in [2004][2005][2006]. Data about occupational pesticide uses -in and outside agriculturewere collected during detailed face-to-face interviews and reviewed by experts for consistency and exposure assignment. Odds ratios (ORs) and 95% con dence intervals ( 95% CI) were estimated with conditional logistic regression.Results: A total of 596 cases (273 gliomas, 218 meningiomas, 105 others) and 1 192 age-and sex-matched controls selected in the general population were analyzed. Direct and indirect exposures to pesticides in agriculture were respectively assigned to 125 (7.0%) and 629 (35.2%) individuals and exposure outside agriculture to 146 (8.2%) individuals. For overall agricultural exposure, we observed no increase in risk for all brain tumors (OR=1.04, 0.69-1.57) and a slight increase for gliomas (OR=1.37, 0.79-2.39). Risks for gliomas were higher when considering agricultural exposure for more than 10 years (OR=2.22, 0.94-2.24) and signi cantly trebled in open eld agriculture (OR=3.58, 1.20-0.70). Increases in risk were also observed in non-agricultural exposures, especially in green space workers who were directly exposed (OR=1.89, 0.82-4.39), and these were statistically signi cant for those exposed for over 10 years (OR=2.84, 1.15-6.99).Discussion: These data support some previous ndings regarding the potential role of occupational exposures to pesticides in CNS tumors, both inside and outside agriculture.

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“…As the impact of the overuse of synthetic fungicides will become increasingly apparent due to the rising threat of resistant pathogens and the deleterious effects on soil productivity and human and animal health, alternatives need to be explored [7,9,12,109]. In this regard, research has focused on BCAs, as their toxicological risks to humans and the environment are low.…”

Section: Future Perspectivesmentioning

confidence: 99%

“…First, concerns have been raised over the residual effects and toxicity that affect the environment and human health. For example, fungicides, and other types of pesticides, have recently been linked to cancer and respiratory and hormone imbalance diseases, thereby depending on the level of exposure [7][8][9]. Driven by the opinion of consumers, who perceive pesticides as a threat, and the vast amount of research supporting this view, regulators have approved laws that result in either banning or restricting their use by imposing lower maximum residue limits (MRLs) [10,11].…”

Section: Introductionmentioning

confidence: 99%

Combining Biocontrol Agents with Chemical Fungicides for Integrated Plant Fungal Disease Control

et al. 2020

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Feeding a rising population of currently 7.8 billion people globally requires efficient agriculture, which is preferably sustainable. Today, farmers are largely dependent on synthetic fungicides to avoid food losses caused by fungal diseases. However, the extensive use of these has resulted in the emergence of fungicide-resistant pathogens and concerns have been raised over the residual effects on the environment and human health. In this regard, biocontrol agents (BCAs) have been proposed as an alternative to standard fungicides but their disease management capacity is usually incomplete and heavily relies on uncontrollable environmental conditions. An integrated approach combining BCAs with fungicides, which is the focus of this review, is put forward as a way to reduce the fungicide doses to manage plant diseases and thereby their residue on harvested crops. In addition, such a strategy of combining antifungal treatments with different modes of action reduces the selection pressure on pathogens and thereby the chances of resistance development. However, to allow its large-scale implementation, further knowledge is needed, comprising timing, number and interval of repeated BCA applications and their compatibility with fungicides. The compatibility of BCAs with fungicides might differ when applied in a mixture or when used in alternation.

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Agricultural exposures to carbamate herbicides and fungicides and central nervous system tumour incidence in the cohort AGRICAN

Cited by 57 publications

References 32 publications

Differential interactions of carbamate pesticides with drug transporters

Differential interactions of carbamate pesticides with drug transporters

Occupational exposure to pesticides and central nervous system tumors: results from the CERENAT case–control study

Combining Biocontrol Agents with Chemical Fungicides for Integrated Plant Fungal Disease Control

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