Agreement of white-to-white measurements with swept-source OCT, Scheimpflug and color LED devices

Abstract

Purpose To assess the interchangeability of different devices for measuring white-to-white (WTW) distance. Methods WTW distance was measured in 53 eyes of 53 patients using Anterion swept-source optical coherence topographer (SS-OCT), IOLMaster 700 SS-OCT, Pentacam HR Scheimpflug and Cassini color LED. Statistical analysis was done by means of the Friedman test and the post hoc Tukey test. The Bland-Altman analysis was applied to carry out pairwise comparisons with the average difference, 95% confidence interval of the average difference and limits of agreement 95% (LoA). Results WTW values obtained by the Anterion, IOLMaster 700, Pentacam HR and Cassini were: 11.84 ± 0.41 mm, 11.96 ± 0.41 mm, 11.68 ± 0.38 mm and 12.65 ± 0.52 mm, respectively. Statistically significant differences were found in all pairwise comparison (p \ 0.001). The lowest mean difference was found between the Anterion and IOLMaster 700 (-0.11 mm) and the highest between the Pentacam HR and Cassini (-0.96 mm). The widest LoA ranges were those that compared any device with the Cassini. LoA ranges when the other three devices were compared among them were similar: Anterion versus IOLMaster 700, Anterion versus Pentacam HR and IOLMaster versus Pentacam HR (about 0.2 mm). Conclusions Our results show that there were statistically significant differences in WTW measurement among the four devices, but under a clinical point of view, we believe that Anterion and IOLMaster 700 may be considered interchangeable and so Anterion and Pentacam HR, however, IOLMaster 700 and Pentacam HR may not and neither is Cassini with any of the other three devices.

Anterior-Segment Swept-Source Ocular Coherence Tomography and Scheimpflug Imaging Agreement for Keratometry and Pupil Measurements in Healthy Eyes

“…Bland-Altman plots were also constructed using the LoAs to compare both devices. Sample size calculation was based on recent studies that have analyzed agreement between AS-OCT and Scheimpflug devices [6,7]. For a 2-sided level of significance (α) at 0.05 and power (β) of 80%, the sample-size calculation indicated that a minimum of 50 participants was required to detect a difference of 0.1 µm in all measurements.…”

“…Posterior Kf, Ks and Km differed significantly between devices, but mean differences were small and clinically irrelevant. Several studies have compared the performance of Anterion and other devices [6][7][8][9][10], but only one has provided agreement for posterior corneal surface readings [8]. Overall, for biometric measures, Anterion seems to be more interchangeable with other OCT devices such as CASIA or IOL-Master 700.…”

“…Overall, for biometric measures, Anterion seems to be more interchangeable with other OCT devices such as CASIA or IOL-Master 700. Tañá-Rivero et al detected significant differences in WTW measurements taken with the Anterion, IOLMaster 700 (Carl Zeiss Meditec AG, Carl Zeiss Meditec, Jena, Germany) and Pentacam HR, yet concluded that, in clinical terms, Anterion could be considered interchangeable with both these devices [6]. Recently, this group obtained comparable values of keratometry, J0 and J45 vectors, lens thickness, and axial length using the same three devices, but, again, significant differences emerged for anterior chamber depth and central corneal thickness data [7].…”

“…For anterior segment measurements, studies have shown variable repeatability and reproducibility between Pentacam ® HR and Anterion, and between Anterion and other OCT-based devices, such as CASIA (Tomey Corporation, Nagoya, Japan) [6][7][8][9][10]. With regard to the latest research, Brunner et al [11] investigated repeatability coefficients and limits of agreement comparing Pentacam HR, Orbscan IIz, and Tomey Casia SS-1000 measurements.…”

Agreement between Scheimpflug Camera and the Swept-source Optical Coherence Tomography Measurements in Keratometry and Higher-order Aberrations

“…The recently developed ANTERION (Heidelberg Engineering, Heidelberg, Germany) is a highresolution swept-source optical coherence tomography (SS-OCT) device that provides a variety of anterior segment metrics, including anterior, posterior, and total corneal curvatures, as well as HOAs with high resolution, speed, providing an axial length, which calculates the IOL power as well. The high repeatability of anterior segment measurements including HOAs and axial length in ANTERION, has been reported [16][17][18], and the interchangeability in corneal curvature, WTW, pupil diameter, and ACD between other devices such as IOL Master 700 (Carl Zeiss, Jena, Germany), Pentacam (Oculus Inc., Wetzlar, Germany), and Cassini II (i-Optics, Den Haag, Netherlands) have been studied [19][20][21][22].…”