Agreement Between Preoperative Endometrial Sampling and Surgical Specimen Findings in Endometrial Carcinoma

Garcia, Tiago Selbach; Appel, Márcia; Rivero, Raquel Camara; Kliemann, Lúcia Maria; Wender, Maria Celeste Osório

doi:10.1097/igc.0000000000000922

Cited by 25 publications

(23 citation statements)

References 22 publications

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“…In the present study, the grade was upgraded from grade 1 or 2 to grade 3 in only 13 (3.9%) of 314 (94.8%) patients. This rate was consistent with that reported by Garcia et al,Cilesiz Goksedef et al,and Helpman et al (6.4%,5.7%, and 5.6% respectively) [11][12][13]. In the present study, the final postoperative histological grades in 7 (3%) of 235 patients with a preoperative histological grade 1 (71.2%) were upgraded to grade 3, consistent with that reported in the literature.…”

Section: Discussionsupporting

confidence: 93%

“…In the present study, the rate of concordance between preoperative and postoperative grades was 69.7%. This rate is consistent with the rates reported in the literature, i.e., 61% to 71% ( Table 7) [8][9][10][11][12][13].…”

Section: Discussionsupporting

confidence: 92%

“…In other words, approximately 35% of the patients diagnosed with grade 3 disease preoperatively were downgraded in the final pathology report. This rate was consistent with the rates in the literature, which were reported to be between 8% and 42% [8,[10][11][12][13]. The downgrade rates in the final pathological reports are significant in the context of the morbidity and mortality rates related to unnecessary staging surgery.…”

Section: Discussionsupporting

confidence: 90%

“…Although the highest concordance rate was in the grade 1 group in this study and in the study conducted by Helpman et al (78% and 72.3% respectively), in other studies, the highest concordance rate was observed in grade 3 patients [8][9][10][11][12][13]. Garcia et al reported a concordance rate of 79%, and stated that preoperative grade 3 histology is a reliable finding regarding the decision on staging surgery [13]. In the present study, the high concordance in grade 1 patients also caused a significant grade concordance in the low-risk group (MI < 50% and tumour diameter ≤ 2 cm) (p < 0.05).…”

Section: Discussioncontrasting

confidence: 43%

“…In the present study, there was an upgrade to postoperative grade 3 in 6 (7. [10,12,13]. On the other hand, this upgrade rate was 13% and 11.4% in studies by Petersen et al and Cilesiz Goksedef et al,respectively [9,11].…”

Section: Discussionmentioning

confidence: 92%

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Concordance of preoperative and postoperative histological grades in endometrioid type endometrial cancer

2020

EJGO

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Purpose of Investigation: To investigate concordance between grades determined by endometrial sampling and final pathology, and factors affecting this concordance, in endometrioid type endometrial cancer. Materials and Methods: In this retrospective study, 330 endometrioid type endometrial cancer patients were enrolled. For evaluating the concordance between histological grades in preoperative and postoperative pathology reports, Kappa statistic and comparative analyses were performed. Results: In 230 of 330 (69.7%) patients, the endometrial sampling-determined grade was in concordance with the final histological grade. The concordance was minimal according to the Kappa statistic in all patients (K = 0.390; 95% confidence interval = 0.666-0.047; p < 0.01). There was no significant correlation between diabetes mellitus, cancer antigen (Ca) 125, and Ca 19-9 status, and grade concordance (p = 0.86, p = 0.715, p = 0.774, respectively). Conclusion: In endometrioid type endometrial cancer, concordance between preoperative and postoperative histological grades was minimal. Therefore, histological grading by preoperative sampling alone is insufficient for decisionmaking in pelvic lymphadenectomy.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 43%

Section: Discussionmentioning

confidence: 92%

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Concordance of preoperative and postoperative histological grades in endometrioid type endometrial cancer

2020

EJGO

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Amide Proton Transfer‐Weighted Imaging and Multiple Models Diffusion‐Weighted Imaging Facilitates Preoperative Risk Stratification of Early‐Stage Endometrial Carcinoma

Meng

Fang

Feng

et al. 2021

Magnetic Resonance Imaging

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Background Endometrial carcinoma (EC) risk stratification is generally based on histological assessment. It would be beneficial to perform risk stratification noninvasively by MRI. Purpose To investigate the application of amide proton transfer‐weighted imaging (APTWI), monoexponential, biexponential, and stretched exponential intravoxel incoherent motion (IVIM), and diffusion kurtosis imaging (DKI) for the evaluation of risk stratification in early‐stage EC. Study Type Prospective. Population Eighty patients with early‐stage EC (47 classified as low risk, 20 as medium risk, and 13 as high risk by histological grade and International Federation of Gynecology and Obstetrics stage). Field Strength/Sequence T1‐weighted imaging, T2‐weighted imaging, IVIM, APTWI, and DKI MRI at 3 T. Assessment The magnetization transfer ratio asymmetry (MTRasym [3.5 ppm]), apparent diffusion coefficient (ADC), diffusion coefficient (D), pseudo diffusion coefficient (D*), perfusion fraction (f), distributed diffusion coefficient (DDC), water molecular diffusion heterogeneity index (α), mean kurtosis (MK), and mean diffusivity (MD) were calculated and compared between low‐risk and non‐low‐risk groups. Statistical Tests Individual sample t test, analysis of variance, and logistic regression. A P‐value <0.05 was considered statistically significant. Results The α, ADC, D, DDC, and MD were significantly higher and the f, MK, and MTRasym (3.5 ppm) were significantly lower in the low‐risk group than in the non‐low‐risk group. The difference in D* between the two groups was not significant (P = 0.289). MTRasym (3.5 ppm), D, and MK were independent predictors of risk stratification. The combination of these three parameters was better able to identify low‐ and non‐low‐risk groups than each individual parameter. Data Conclusion The IVIM, DKI, and APTWI parameters have potential as imaging markers for risk stratification in early‐stage EC. Level of Evidence 2 Technical Efficacy Stage 3

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Updated endometrial cancer FIGO staging: the role of MRI in determining newly included histopathological criteria

Akçay,

Gültekin,

Altıntaş

et al. 2024

Abdom Radiol

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Agreement Between Preoperative Endometrial Sampling and Surgical Specimen Findings in Endometrial Carcinoma

Cited by 25 publications

References 22 publications

Concordance of preoperative and postoperative histological grades in endometrioid type endometrial cancer

Concordance of preoperative and postoperative histological grades in endometrioid type endometrial cancer

Amide Proton Transfer‐Weighted Imaging and Multiple Models Diffusion‐Weighted Imaging Facilitates Preoperative Risk Stratification of Early‐Stage Endometrial Carcinoma

Updated endometrial cancer FIGO staging: the role of MRI in determining newly included histopathological criteria

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