Agreement between histopathological and intraoperative classifications for pediatric appendicitis and its relationship with the post-operative clinical outcome

Abstract

IntroductionSome studies have shown poor agreement between intraoperative and histopathological classifications for appendicitis, despite their routine use in clinical practice.ObjectiveTo investigate the agreement between histopathological and intraoperative classifications for pediatric appendicitis and evaluate the predictive potential of these classifications for the post-operative outcome.MethodsA retrospective, longitudinal, observational single-center study, carried out with 485 patients up to15 years of age, with a confirmed diagnosis of acute appendicitis by histopathological evaluation. The histopathological results classified the appendices as uncomplicated appendicitis when there was confirmation of the diagnosis of appendicitis without necrosis or perforation and complicated appendicitis when there was extensive necrotic tissue in the outer layer of the appendix or signs of perforation. The intraoperative findings were classified as uncomplicated appendicitis when the appendix presented with hyperemia and edema or fibrinous exudate and complicated appendicitis when the appendix showed necrosis, abscess, or perforation. The kappa index determined the agreement and the prediction relationships using a generalized linear model.Results43.9% of cases were classified as complicated appendicitis by histopathological evaluation and 49.7% by intraoperative classification. The agreement analysis between the histopathological and intraoperative classification showed a moderate agreement, with a Kappa index of 0.419 (0.337–0.501). There was an association (P < 0.05) between the intraoperative classification and the post-operative clinical outcomes (time to start feeding, fever, intraabdominal collection, length of stay, the need for antibiotic therapy changing, and need for ICU). There was no association between histopathological classification and post-operative outcomes.ConclusionThe agreement between the two classifications was moderate, and the intraoperative classification was able to predict the post-operative clinical outcomes.

Clinical characteristics and prognosis of 69 cases of neonatal appendicitis

“…However, a pathological examination is considered the gold standard method for diagnosing appendicitis. Additionally, some studies have reported a moderate agreement between intraoperative and histopathological examinations to diagnose appendicitis in children 30–32 . Second, this study spanned a long period, and the timing of surgery and the surgeon's skill level affected the postoperative outcomes.…”

“…Additionally, some studies have reported a moderate agreement between intraoperative and histopathological examinations to diagnose appendicitis in children. 30 , 31 , 32 Second, this study spanned a long period, and the timing of surgery and the surgeon's skill level affected the postoperative outcomes. Additionally, some patients with combined Hirschsprung disease underwent enterostomy simultaneously with appendectomy, which could be confounding for the parenteral nutrition time variable.…”